Patents by Inventor Stuart Bloor
Stuart Bloor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20070287834Abstract: The present invention relates to a method for mutation analysis of the HIV pol gene of HIV-1 virions comprising amplifying virion RNA or DNA via nested PCR using outer primers as represented in SEQ ID No. 1 and 2, amplifying said PCR product via nested PCR using a 5? and 3? primer chosen from the inner primers SEQ ID No. 3, 4, 5 and 6, and sequencing this secondary obtained PCR product using at least one sequencing primer chosen from any of SEQ ID No. 7 to 12 or variants thereof. In the alternative, at least one secondary sequencing primer may be used chosen from any of SEQ ID No. 13 to 24. The present invention also relates to kits for performing such a method as well as primers for performing the same.Type: ApplicationFiled: May 14, 2007Publication date: December 13, 2007Inventors: Brendan Larder, Sharon Kemp, Stuart Bloor, Ann Brophy
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Publication number: 20070166747Abstract: The present invention concerns methods for measuring drug resistance by correlating genotypic information with phenotypic profiles. In one embodiment, a method for interpreting genotypic information is described wherein a genetic code is generated from a patient sample, a list of mutations known or suspect to play a role in the development of resistance to one or more drugs is obtained from the generated genetic code, a genotype database is interrogated for previous samples with similar mutations relating to said one or more drugs, a phenotype for said sample is located in a phenotype database, the mean change in inhibition is determined based on all the examples located in said phenotype database, a distribution of sensitivities of one or more drugs suitable for treating a specific indication is determined.Type: ApplicationFiled: March 6, 2007Publication date: July 19, 2007Applicant: Virco N.V.Inventors: Brendan Larder, Stuart Bloor, Kurt Hertogs, Pascale Dehertogh, Rudy Mortier
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Patent number: 7235387Abstract: The present invention relates to a method for mutation analysis of the HIV pol gene of HIV virions comprising amplifying virion RNA or DNA via nested PCR using outer primers as represented in SEQ ID No. 1 and 2, amplifying said PCR product via nested PCR using a 5? and 3? primer chosen from the inner primers SEQ ID No. 3, 4, 5, and 6, and sequencing this secondary obtained PCR product using at least one sequencing primer chosen from any of SEQ ID No. 7 to 12 or variants thereof. In the alternative, at least one secondary sequencing primer may be used chosen from any of SEQ ID No. 13 to 24. The benefit of the sequences present in the invention resides in the fact that, with the aid of the oligonucleotides, the sequences of all presently known HIV subtypes and all mutations of the pol gene presently known to yield resistance towards antiretroviral therapy can be determined. The present invention also relates to kits for performing such a method as well as primers for performing the same.Type: GrantFiled: April 20, 2001Date of Patent: June 26, 2007Assignee: Virco BVBAInventors: Brendan Larder, Sharon Kemp, Stuart Bloor, Ann Brophy
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Patent number: 7206699Abstract: The present invention concerns methods for measuring drug resistance by correlating genotypic information with phenotypic profiles. In one embodiment, a method for interpreting genotypic information is described wherein a genetic code is generated from a patient sample, a list of mutations known or suspect to play a role in the development of resistance to one or more drugs is obtained from the generated genetic code, a genotype database is interrogated for previous samples with similar mutations relating to said one or more drugs, a phenotype for said sample is located in a phenotype database, the mean change in inhibition is determined based on all the examples located in said phenotype database, a distribution of sensitivities of one or more drugs suitable for treating a specific indication is determined.Type: GrantFiled: April 18, 2001Date of Patent: April 17, 2007Assignee: Virco N.V.Inventors: Brendan Larder, Stuart Bloor, Kurt Hertogs, Pascale Alfons Rosa Dehertogh, Rudy Jean Marc Mortier
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Publication number: 20050064397Abstract: The present invention relates to a method of for mutation analysis of the HIV pol gene of HIV-1 virions comprising amplifying viral RNA or DNA via nested PCR using outer primers as represented in SEQ ID No: 1 and 2, amplifying said PCR product via nested PCR using a 5? and 3? primer chosen from the inner primers SEQ ID No: 3, 4, 5, and 6, and sequencing this secondary obtained PCR product using at least one sequencing primer chosen from any of SEQ ID No: 7 to 12 or variants thereof. In the alternative, at least one secondary sequencing primer may be used chosen from any of SEQ ID No: 13 to 24. The present invention also relates to kits for performing such a method as well as primers for performing the same.Type: ApplicationFiled: September 8, 2004Publication date: March 24, 2005Inventors: Brendan Larder, Sharon Kemp, Stuart Bloor, Ann Brophy
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Patent number: 6800463Abstract: The present invention relates to a method of for mutation analysis of the HIV pol gene of HIV-1 virions comprising amplifying viral RNA or DNA via nested PCR using outer primers as represented in SEQ ID No: 1 and 2, amplifying said PCR product via nested PCR using a 5′ and 3′ primer chosen from the inner primers SEQ ID No: 3, 4, 5, and 6, and sequencing this secondary obtained PCR product using at least one sequencing primer chosen from any of SEQ ID No: 7 to 12 or variants thereof. In the alternative, at least one secondary sequencing primer may be used chosen from any of SEQ ID No: 13 to 24. The present invention also relates to kits for performing such a method as well as primers for performing the same.Type: GrantFiled: August 18, 2000Date of Patent: October 5, 2004Assignee: Virco BvbaInventors: Brendan Larder, Sharon Kemp, Stuart Bloor, Ann Brophy
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Publication number: 20040137436Abstract: The present invention concerns methods for measuring drug resistance by correlating genotypic information with phenotypic profiles. In one embodiment, a method for interpreting genotypic information is described wherein a genetic code is generated from a patient sample, a list of mutations known or suspect to play a role in the development of resistance to one or more drugs is obtained from the generated genetic code, a genotype database is interrogated for previous samples with similar mutations relating to said one or more drugs, a phenotype for said samples is located in a phenotype database, the mean change in inhibition is determined based on all the examples located in said phenotype database, and a phenotype is determined for the patients sample. Furthermore, methods are provided for predicting a phenotype from a biological sample and for predicting drug or therapy resistance of a patient, a pathogen or a malignant cell.Type: ApplicationFiled: November 24, 2003Publication date: July 15, 2004Inventors: Brendan Larder, Stuart Bloor, Kurt Hertogs, Pascale Alfons Rosa Dehertogh, Rudy Jean Marc Mortier
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Publication number: 20020091664Abstract: The present invention concerns methods for measuring drug resistance by correlating genotypic information with phenotypic profiles. In one embodiment, a method for interpreting genotypic information is described wherein a genetic code is generated from a patient sample, a list of mutations known or suspect to play a role in the development of resistance to one or more drugs is obtained from the generated genetic code, a genotype database is interrogated for previous samples with similar mutations relating to said one or more drugs, a phenotype for said sample is located in a phenotype database, the mean change in inhibition is determined based on all the examples located in said phenotype database, a distribution of sensitivities of one or more drugs suitable for treating a specific indication is determined.Type: ApplicationFiled: April 18, 2001Publication date: July 11, 2002Inventors: Brendan Larder, Stuart Bloor, Kurt Hertogs, Pascale Alfons Rosa Dehertogh, Rudy Jean Marc Mortier
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Patent number: 6334260Abstract: A strata movement indicator suspended within a borehole 1 is provided with a drive element 6 and a reference element 12, relative movement between the elements being translated into rotary motion to give a visual indication on an indicator 10, 24 on the respective elements.Type: GrantFiled: February 28, 2000Date of Patent: January 1, 2002Assignee: Rock Mechanics Technology LimitedInventors: Alan Stuart Bloor, Paul Alan Fletcher