Abstract: A transcatheter valve prosthesis includes a stent and a prosthetic valve disposed within and secured to the stent. The stent includes an inflow portion comprising a plurality of rows of angled struts, an outflow portion including at least one row of angled struts, and a transition portion extending between the inflow portion and the outflow portion, the transition portion including a plurality of commissure posts extending between the inflow portion and the outflow portion and a plurality of axial struts extending between the inflow portion and the outflow portion. The prosthesis further includes inflow markers positioned within the inflow portion of the stent and outflow markers positioned in the transition portion and/or the outflow portion of the stent. The inflow markers and the outflow markers are radiopaque markers configured to be visible relative to the stent in one or more images captured during installation at the native heart valve.

Abstract: A transcatheter valve prosthesis includes a stent having a crimped configuration for delivery within a vasculature and an expanded configuration for deployment within a native heart valve. The stent includes an inflow portion, an outflow portion, and at least one commissure post positioned at least partially in the outflow portion of the stent. The transcatheter valve prosthesis includes an inflow marker positioned within the inflow portion of the stent, the inflow marker including a first radiopaque material. The transcatheter valve prosthesis includes an outflow marker positioned on the at least one commissure post, the outflow marker including a second radiopaque material. The first radiopaque material and the second radiopaque material cause the inflow marker and the outflow marker to be visible relative to the stent in one or more images captured during the installation at the implant location.

Abstract: A heart valve prosthesis includes an inner stent, an outer stent at least partially surrounding the inner stent, and a prosthetic valve operatively coupled to the inner stent. The outer stent includes a plurality of struts and nodes defining open cells of the outer stent, and a plurality of cleats. The plurality of cleats includes first strut cleats extending radially outwardly and proximally from first struts of a first row of the plurality of struts with the heart valve prosthesis in a radially expanded configuration.

Abstract: A transcatheter valve prosthesis includes a stent having a crimped configuration for delivery within a vasculature and an expanded configuration for deployment within a native heart valve. The stent includes at least one axial frame member. The transcatheter valve prosthesis includes at least one outflow marker positioned on the at least one axial frame member. The transcatheter heart valve prosthesis may include inflow markers positioned within the inflow portion of the stent. The transcatheter heart valve prosthesis may include two outflow markers disposed on axial frame members, the two outflow markers being circumferentially and longitudinally offset from each other. The markers are configured to aid in axial and circumferential alignment of the transcatheter heart valve prosthesis within a native heart valve.

Abstract: A transcatheter valve prosthesis includes a stent having a crimped configuration for delivery within a vasculature and an expanded configuration for deployment within a native heart valve. The stent includes at least one axial frame member. The transcatheter valve prosthesis includes at least one outflow marker positioned on the at least one axial frame member. The transcatheter heart valve prosthesis may include inflow markers positioned within the inflow portion of the stent. The transcatheter heart valve prosthesis may include two outflow markers disposed on axial frame members and being circumferentially and longitudinally offset from each other. The markers are configured to aid in axial and circumferential aligned of the transcatheter heart valve prosthesis within a native heart valve.

Abstract: The techniques of this disclosure generally relate to a valve prosthesis including a one piece molded prosthetic valve and a stent structure having an outflow crown ring. The outflow crown ring includes inferior crowns, superior crowns, and outflow crown struts connected to the superior crowns and the inferior crowns. An internal radius of the superior crowns is within the range of 0.3 to 0.5 millimeters (mm). The internal radius of the superior crowns is made sufficiently large to prevent flaring outward of the superior crowns on deployment and to make the superior crowns atraumatic. This reduces and essentially eliminates the chance of contact with the aortic sinus or the ascending aorta. Further, in the event there is contact, the atraumatic shape of the superior crowns minimizes the abrasion of the vessel.

Abstract: A transcatheter valve prosthesis includes a stent having a crimped configuration for delivery within a vasculature and an expanded configuration for deployment within a native heart valve. The stent includes an inflow portion, an outflow portion, and at least one commissure post positioned at least partially in the outflow portion of the stent. The transcatheter valve prosthesis includes an inflow marker positioned within the inflow portion of the stent, the inflow marker including a first radiopaque material. The transcatheter valve prosthesis includes an outflow marker positioned on the at least one commissure post, the outflow marker including a second radiopaque material. The first radiopaque material and the second radipaque material cause the inflow marker and the outflow marker to be visible relative to the stent in one or more images captured during the installation at the implant location.

Abstract: A transcatheter valve prosthesis includes a stent having a crimped configuration for delivery within a vasculature and an expanded configuration for deployment within a native heart valve. The stent includes at least one axial frame member. The transcatheter valve prosthesis includes at least one outflow marker positioned on the at least one axial frame member. The transcatheter heart valve prosthesis may include inflow markers positioned within the inflow portion of the stent. The transcatheter heart valve prosthesis may include two outflow markers disposed on axial frame members and being circumferentially and longtiduinally offset from each other. The markers are configured to aid in axial and circumferential aligned of the transcatheter heart valve prosthesis within a native heart valve.

Abstract: The endovascular graft includes a dual chamber cuff structure. The endovascular graft includes a tubular structure having a first end and a second end. The tubular structure has a wall defining a lumen between the first and second ends. The endovascular graft includes a cuff circumferentially secured to the tubular structure. The cuff has an interior cavity which is bifurcated such that the interior cavity includes a circumferential outer chamber and a circumferential inner chamber. The method for forming the endovascular graft includes inserting an expansion substance into the inner chamber to resist a luminal intrusion of the tubular structure resulting from the insertion of the expansion substance into the outer chamber. The expansion substance within the outer chamber is stiffened. The expansion substance within the inner chamber is removed.

Abstract: The endovascular graft includes a dual chamber cuff structure. The endovascular graft includes a tubular structure having a first end and a second end. The tubular structure has a wall defining a lumen between the first and second ends. The endovascular graft includes a cuff circumferentially secured to the tubular structure. The cuff has an interior cavity which is bifurcated such that the interior cavity includes a circumferential outer chamber and a circumferential inner chamber. The method for forming the endovascular graft includes inserting an expansion substance into the inner chamber to resist a luminal intrusion of the tubular structure resulting from the insertion of the expansion substance into the outer chamber. The expansion substance within the outer chamber is stiffened. The expansion substance within the inner chamber is removed.

Abstract: This invention is a system for the treatment of body passageways; in particular, vessels with vascular disease. The system includes an endovascular graft with a low-profile delivery configuration and a deployed configuration in which it conforms to the morphology of the vessel or body passageway to be treated as well as various connector members and stents. The graft is made from an inflatable graft body section and may be bifurcated. One or more inflatable cuffs may be disposed at either end of the graft body section. At least one inflatable channel is disposed between and in fluid communication with the inflatable cuffs.

Abstract: An intracorporeal device, such as an endovascular graft, having a tubular section with circumferential or helical radial support members. The radial support members may be inflatable channels which support the tubular structure of the graft and which are appropriately sized and longitudinally spaced to prevent or reduce kinking of the tubular structure upon bending of the tubular structure.

Abstract: This invention is a system for the treatment of body passageways; in particular, vessels with vascular disease. The system includes an endovascular graft with a low-profile delivery configuration and a deployed configuration in which it conforms to the morphology of the vessel or body passageway to be treated as well as various connector members and stents. The graft is made from an inflatable graft body section and may be bifurcated. One or more inflatable cuffs may be disposed at either end of the graft body section. At least one inflatable channel is disposed between and in fluid communication with the inflatable cuffs.

Abstract: An aircraft fuel tank construction for providing enhanced fuel tank survivability and aircraft structural integrity when the fuel tank is penetrated by an exploding projectile, utilizes selective placement of low density, fluid-displacing material to create a low shock impedance region which decouples protected fuel tank structure from the destructive effects of a shock wave. The low shock impedance region may be formed using closed cell foam, or using isolators comprising bladders inflated with a compressible, inert gas. Such bladders should have a wedge shape and a wedge angle of at least 15 degrees. Precise shape is less important with closed cell foam. Polymethylacrilimide has been shown to be particularly effective for this purpose. Finite element analysis is useful in tuning the design of actual low shock impedance regions for actual aircraft designs.