Abstract: Method for treatment of the body with localized energy application in combination with other treatments to facilitate cluster tissue ablation and increase immune response including a method of treatment of a localized treatment area of a body including injection, IV or otherwise to entrap and/saturate a localized treatment area to be used singularly or in combination with: a high electric conductive material comprising a saline solution, hypertonic saline solution, a solution with metallic compounds, metals, nanoparticles, gel, polymers, high-polarity molecules, peptides, liposomes to treat and cause preferential heating and effect secondary conductive heating from cluster sites to adjacent tissues using external or intracavitary energy applicators.