Abstract: The present application relates to a compound of Formula I, or a salt, hydrate or solvate thereof, as defined herein. The present compounds are found to have pharmacological effects, particularly at MRCK. Further provided are pharmaceutical compositions comprising said compounds. The present invention also relates to the use of these compounds as therapeutic agents, in particular, for the treatment and/or prevention of proliferative diseases, such as cancer.

Abstract: Disclosed herein are indole derivatives of the formula (I) wherein each of the substitutents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions containing the indole derivatives and use of the derivatives for the treatment of pain.

Abstract: Method and apparatus for controlling a brushless dc motor, such as the type used in a data storage device to rotate data storage media. A sequence of drive pulses is applied to rotate the motor. The sequence is switched from first to second motor commutation states at a time determined in relation to changes in elapsed time between successive pulses in the sequence. Each drive pulse has a duration established in relation to an inductance of the motor, and is separated from adjacent pulses by an intermediate delay of predetermined value. A peak elapsed time interval between successive pulses is identified, and the next commutation state is switched in at a selected time after the peak time interval. The sequence preferably accelerates the motor from rest to an intermediate velocity, after which back electromotive force (bemf) commutation is used to accelerate the motor to a final operational velocity.