Abstract: A nutritional supplement includes elements having been shown to enhance DNA repair or reduce DNA damage by different molecular mechanisms while excluding other bioactive nutrient agents which compete with any of the elements known modes of action. The supplement includes a resveratrol, a carotenoid, a nicotinamide, a dimethylaminoethanol, a zinc source, and a quinic acid analog. The supplement is administered daily in dosages in excess of normal dietary levels. The supplement improves resistance to DNA damage, enhances DNA repair capacity in tissues including skin, and stimulates immune cellular function. This was accomplished by reducing metabolic competition between DNA repair bioactive components that was in turn paralleled by enhancement of thirst quenching properties in aqueous formulations.

Abstract: Selectively administering to humans, as a daily dosage, a combination of resveratrol-carotenoids, nicotinamide (or niacin or a precursor thereof) and a source of zinc, in excess of normal dietary levels, for improving resistance to DNA damage, enhancing DNA repair capacity, and stimulating immune function.