Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting a SOD1 gene, as well as methods of inhibiting expression of a SOD1 gene and methods of treating subjects having a SOD1-associated neurodegenerative disease or disorder, e.g., Amyotrophic Lateral Sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), and Down's syndrome (DS), using such dsRNAi agents and compositions.

Abstract: Disclosed are various embodiments that relate to enhancing video content with extrinsic data. A video content feature is rendered on a display. A user interface can be rendered on top of the video content feature on the display. The user interface can presents cast member indicia, where the cast member indicia correspond to respective cast members in the video content feature. In response to receiving a selection of one of the cast member indicia from a user, the user interface is updated to present a timeline component. A sequence of scenes from the video content feature are played. The sequence of scenes can correspond to scenes in which a selected cast member appear.

Abstract: Disclosed are various embodiments that relate to enhancing video content with personalized extrinsic data. A video content feature is rendered on a display. A user interface is rendered on top of the video content feature on the display. The user interface presents cast member indicia, where the cast member indicia correspond to respective cast members in the video content feature. In response to receiving a selection of one of the cast member indicia from a user, the user interface is updated to present additional information about the corresponding cast member. The additional information is personalized based at least in part on profile data associated with the user.

Abstract: A lightweight, four stroke engine includes a crankcase enclosure and at least one piston assembly disposed within the crankcase enclosure. The piston assembly cooperates with the crankcase enclosure to provide an internal pressure to the crankcase enclosure which varies between a positive and a negative pressure. An air intake assembly is operatively coupled to a first section of the engine and the crankcase enclosure, the air intake assembly including at least one air conduit configured to provide non-combustive air flow from the first section of the engine to the crankcase enclosure of the engine. At least one valve is disposed within the air intake system, the valve being configured to restrict air flow from the crankcase enclosure when positively pressurized and to allow airflow into the crankcase enclosure when negatively pressurized.

Abstract: A lightweight, four stroke engine includes a crankcase enclosure and at least one piston assembly disposed within the crankcase enclosure. The piston assembly cooperates with the crankcase enclosure to provide an internal pressure to the crankcase enclosure which varies between a positive and a negative pressure. An air intake assembly is operatively coupled to a first section of the engine and the crankcase enclosure, the air intake assembly including at least one air conduit configured to provide non-combustive air flow from the first section of the engine to the crankcase enclosure of the engine. At least one valve is disposed within the air intake system, the valve being configured to restrict air flow from the crankcase enclosure when positively pressurized and to allow airflow into the crankcase enclosure when negatively pressurized.

Abstract: A lightweight, four stroke engine includes a crankcase enclosure and at least one piston assembly disposed within the crankcase enclosure. The piston assembly cooperates with the crankcase enclosure to provide an internal pressure to the crankcase enclosure which varies between a positive and a negative pressure. An air intake assembly is operatively coupled to a first section of the engine and the crankcase enclosure, the air intake assembly including at least one air conduit configured to provide non-combustive air flow from the first section of the engine to the crankcase enclosure of the engine. At least one valve is disposed within the air intake system, the valve being configured to restrict air flow from the crankcase enclosure when positively pressurized and to allow airflow into the crankcase enclosure when negatively pressurized.