Abstract: The present disclosure relates to a mutant neuroserpin protein or portion thereof, to a nucleic acid comprising nucleotide sequence which encodes a mutant neuroserpin protein or portion thereof, and to use of the nucleic acid or mutant neuroserpin protein or portion thereof for treating glaucoma and other disorders associated with elevated plasmin activity.

Abstract: Embodiments of the present invention are directed to flexible, user-adapted, continuous searching, on behalf of a particular user, for points of interest relevant to the user's current location within a specifically computed personal region of interest. In a general case, the personal region of interest is computed as a function of the user's level of disposition towards the searched-for points of interest. The level of disposition towards the searched-for points of interest may, in turn, be based on two or more of the user's location, the current date and time, a history of the user's interaction with the POI-searching system, including user-initiated searches and user selections from displayed search results, a user profile developed for, and continuously updated on behalf of, the user, and a current context for the search, as specified by a search query or by other context-specifying means.

Abstract: Embodiments of the present invention are directed to flexible, user-adapted, continuous searching, on behalf of a particular user, for points of interest relevant to the user's current location within a specifically computed personal region of interest. In a general case, the personal region of interest is computed as a function of the user's level of disposition towards the searched-for points of interest. The level of disposition towards the searched-for points of interest may, in turn, be based on two or more of the user's location, the current date and time, a history of the user's interaction with the POI-searching system, including user-initiated searches and user selections from displayed search results, a user profile developed for, and continuously updated on behalf of, the user, and a current context for the search, as specified by a search query or by other context-specifying means.

Abstract: A media delivery system that may be used for tracking the number and type of human impressions of media content rendered by the system during the time the media was rendered is provided. The media delivery system includes a rendering device for rendering media content, an environmental sensor for sensing impressions and other environmental variables and a computing device configured to gather data related to the external states detected by the environmental sensor. The data may be provided to a backend server for correlating the data to the rendered media content. The system may include rules that interpret that data and may cause the system to custom select, tailor or control future playback of media on the system.

Abstract: A back-channel media delivery system that may be used for tracking the number and type of human impressions of media content rendered by the system during the time the media was rendered is provided. The back-channel media delivery system includes a rendering device for rendering media, an environmental sensor for sensing impressions and other environmental variables and a computing device configured to play media on the rendering device, and gather data related to the external states detected by the environmental sensor. The system may include rules that interpret that data and may cause the system to custom select, tailor or control future playback of media on the system.

Abstract: A system for publishing advertising media on a plurality of media delivery systems, each configured to render media and gather environmental data while rendering the media. The system includes a front-end system in communication with the plurality of media delivery systems. The front-end system is configured to permit an advertiser to select at least one of the plurality of media delivery systems on which to render advertising media and is further configured to accept advertising media uploaded by the advertiser. The system further includes a back-end system in communication with the front-end system and the plurality of media delivery systems. The back-end system is configured to upload the advertising media to the selected media delivery systems for rendering and is further configured to upload the environmental data from the plurality of media delivery systems.

Abstract: Embodiments of the present invention are directed to flexible, user-adapted, continuous searching, on behalf of a particular user, for points of interest relevant to the user's current location within a specifically computed personal region of interest. In a general case, the personal region of interest is computed as a function of the user's level of disposition towards the searched-for points of interest. The level of disposition towards the searched-for points of interest may, in turn, be based on two or more of the user's location, the current date and time, a history of the user's interaction with the POI-searching system, including user-initiated searches and user selections from displayed search results, a user profile developed for, and continuously updated on behalf of, the user, and a current context for the search, as specified by a search query or by other context-specifying means.

Abstract: Various system embodiments of the present invention are directed to an automated concierge system through which users of the automated concierge system can request and obtain many types of information and services. Unlike traditional search engines and electronic query-processing interfaces, the automated concierge systems provide much greater flexibility with respect to means of access, including types of electronic devices and communications media that can be used to access the concierge services, greater flexibility in the timing of responses to information and service requests, more efficient information and service provision, and access to a much broader range of information sources and service providers.

Abstract: Embodiments of the present invention are directed to flexible, user-adapted, continuous searching, on behalf of a particular user, for points of interest relevant to the user's current location within a specifically computed personal region of interest. In a general case, the personal region of interest is computed as a function of the user's level of disposition towards the searched-for points of interest. The level of disposition towards the searched-for points of interest may, in turn, be based on two or more of the user's location, the current date and time, a history of the user's interaction with the POI-searching system, including user-initiated searches and user selections from displayed search results, a user profile developed for, and continuously updated on behalf of, the user, and a current context for the search, as specified by a search query or by other context-specifying means.

Abstract: Embodiments of the present invention are directed to flexible, user-adapted, continuous searching, on behalf of a particular user, for points of interest relevant to the user's current location within a specifically computed personal region of interest. In a general case, the personal region of interest is computed as a function of the user's level of disposition towards the searched-for points of interest. The level of disposition towards the searched-for points of interest may, in turn, be based on two or more of the user's location, the current date and time, a history of the user's interaction with the POI-searching system, including user-initiated searches and user selections from displayed search results, a user profile developed for, and continuously updated on behalf of, the user, and a current context for the search, as specified by a search query or by other context-specifying means.

Abstract: Various system embodiments of the present invention are directed to an automated concierge system through which users of the automated concierge system can request and obtain many types of information and services. Unlike traditional search engines and electronic query-processing interfaces, the automated concierge systems provide much greater flexibility with respect to means of access, including types of electronic devices and communications media that can be used to access the concierge services, greater flexibility in the timing of responses to information and service requests, more efficient information and service provision, and access to a much broader range of information sources and service providers.

Abstract: A method, system and products thereby for enhanced customer loyalty program with improved access to restaurant information. The system having a server configured to perform operations including storing data including at least an identifier associated with a customer account in the customer rewards program, the identifier corresponding to a registered credit card number. The server may be further configured to receive the data from a merchant terminal relating to a qualified purchase, the merchant terminal being located at one of the plurality of independent merchants participating in the closed coalition customer rewards program, and verify a customer's membership in the closed coalition customer rewards program. Additionally, the server may be further configured to transfer an award associated with the qualified purchase transaction to the customer account, and process a customer's directive for redeeming the award for use at the participating restaurant.

Abstract: A media delivery system that may be used for tracking the number and type of human impressions of media content rendered by the system during the time the media was rendered is provided. The media delivery system includes a rendering device for rendering media content, an environmental sensor for sensing impressions and other environmental variables and a computing device configured to gather data related to the external states detected by the environmental sensor. The data may be provided to a backend server for correlating the data to the rendered media content. The system may include rules that interpret that data and may cause the system to custom select, tailor or control future playback of media on the system.

Abstract: A method and system for promoting customer loyalty to an anchor business within a certain geographical region from a plurality of participating merchants. The system having a server configured to store data including an identifier associated with a customer account in a customer rewards program. The server may receive the data and purchase transaction amount from a merchant terminal, verify a customer's membership in the customer rewards program, and transfer an award associated with the purchase transaction amount to the customer account. Additionally, the server may process customer's directive for redeeming the award for use at the anchor business.

Abstract: A method, system and products thereby for enhanced customer loyalty program with improved access to restaurant information. The system having a server configured to perform operations including storing restaurant data of a participating restaurant in a database and retrieving the restaurant data in response to a search engine command. The server may be further configured to receive electronic notification from the participating restaurant of a qualified purchase transaction associated with a customer account in a customer rewards program. Additionally, the server may be further configured to transfer an award associated with the qualified purchase transaction to the customer account, and process a customer's directive for redeeming the award for use at the participating restaurant.

Abstract: A closed loop loyalty, recognition and rewards program for merchants. Each merchant decides upon their own rewards criteria and similar or analogous identification systems are used to identify customers who are loyal customers of several merchants in a community. This works in conjunction with a system for identifying a customer's product based upon equity accumulation, the system having a memory and a remote processor. The consumer is issued for example, a chip in one embodiment which is RFID enabled and when the consumer enters the business their data comes up on the screen and loyalty programs that are customized for that merchant based upon the frequency of visits by the consumer, may be accessed. The two criteria for rewards are based upon number of visits and a timeframe specified by the merchant, likewise the system is designed so the merchants can communicate with their consumers and invite them to special events or make them aware of special offers.

Abstract: Embodiments of the present invention are directed to flexible, user-adapted, continuous searching, on behalf of a particular user, for points of interest relevant to the user's current location within a specifically computed personal region of interest. In a general case, the personal region of interest is computed as a function of the user's level of disposition towards the searched-for points of interest. The level of disposition towards the searched-for points of interest may, in turn, be based on two or more of the user's location, the current date and time, a history of the user's interaction with the POI-searching system, including user-initiated searches and user selections from displayed search results, a user profile developed for, and continuously updated on behalf of, the user, and a current context for the search, as specified by a search query or by other context-specifying means.

Abstract: Embodiments of the present invention are directed to flexible, user-adapted, continuous searching, on behalf of a particular user, for points of interest relevant to the user's current location within a specifically computed personal region of interest. In a general case, the personal region of interest is computed as a function of the user's level of disposition towards the searched-for points of interest. The level of disposition towards the searched-for points of interest may, in turn, be based on two or more of the user's location, the current date and time, a history of the user's interaction with the POI-searching system, including user-initiated searches and user selections from displayed search results, a user profile developed for, and continuously updated on behalf of, the user, and a current context for the search, as specified by a search query or by other context-specifying means.

Abstract: A system for publishing advertising media on a plurality of media delivery systems, each configured to render media and gather environmental data while rendering the media. The system includes a front-end system in communication with the plurality of media delivery systems. The front-end system is configured to permit an advertiser to select at least one of the plurality of media delivery systems on which to render advertising media and is further configured to accept advertising media uploaded by the advertiser. The system further includes a back-end system in communication with the front-end system and the plurality of media delivery systems. The back-end system is configured to upload the advertising media to the selected media delivery systems for rendering and is further configured to upload the environmental data from the plurality of media delivery systems.

Abstract: A back-channel media delivery system that may be used for tracking the number and type of human impressions of media content rendered by the system during the time the media was rendered is provided. The back-channel media delivery system includes a rendering device for rendering media, an environmental sensor for sensing impressions and other environmental variables and a computing device configured to play media on the rendering device, and gather data related to the external states detected by the environmental sensor. The system may include rules that interpret that data and may cause the system to custom select, tailor or control future playback of media on the system.