Abstract: A method of producing a particle cassette for a needleless syringe device which alleviates problems of providing a chamber for the confinement of particles which is hermetically sealed from the environment. A predetermined force is applied in the longitudinal direction to push first and second cassette parts together so as to cause plastic deformation of a portion of the first cassette part so as to create said hermetically sealed chamber. The cassette parts are preferably made of PETG and have bonded thereto rupturable membranes preferably made of PET. The sealing is preferably achieved at the end of a protrusion on the first cassette part which is tapered and which interacts with the membrane of the second cassette part.

Abstract: A method of producing a particle cassette for a needleless syringe device which alleviates problems of providing a chamber for the confinement of particles which is hermetically sealed from the environment. A predetermined force is applied in the longitudinal direction to push first and second cassette parts together so as to cause plastic deformation of a portion of the first cassette part so as to create said hermetically sealed chamber. The cassette parts are preferably made of PETG and have bonded thereto rupturable membranes preferably made of PET. The sealing is preferably achieved at the end of a protrusion on the first cassette part which is tapered and which interacts with the membrane of the second cassette part.

Abstract: A syringe, for use in the delivery of a dose of a therapeutic agent entrained within a pressurized fluid flow, includes an upstream portion, an intermediate portion, a downstream portion, and an actuator mechanism for initiating a flow of the fluid through the syringe. The upstream portion is interfaced with a source of fluid under pressure. The intermediate portion, which is interposed between the upstream and downstream portions, includes first and second members that are coupled together to provide a closed pocket for containing the dose. One of the first and second members is moveable relative to the other within the syringe to provide an open configuration in which the pocket is opened to expose the dose for entrainment by the fluid as it flows through the intermediate portion and to and through the nozzle. Also provided is a capsule formed from the first and second members.