Abstract: A material handling apparatus for reorienting and transferring inventory items to a packaging device includes a support member and a packaging conveyor. The support member receives an inventory item and reorients the item to a rejection orientation or a packaging orientation. The item is moved onto the packaging conveyor in the packaging orientation and is transported to the packaging device.

Abstract: An actuator system for fabricating a cavity within thermoplastic material includes a plurality of actuators arranged in an array. When dimensions of an item are determined, the actuator system may be programmed with data regarding such dimensions to fabricate a cavity for the item. A subset of the actuators, and distances by which each of the actuators is to be extended, may be selected based on dimensions of the item, in order to fabricate a cavity within the thermoplastic material that may accommodate the item therein. Additionally, the actuators and the distances may be selected based on intrinsic or extrinsic data regarding the item, and a cavity fabricated within the thermoplastic material may include one or more buffer zones or protective regions that are specifically formed with respect to aspects of the item.

Abstract: A system and method that causes at least one item to be placed within a portion of an elastic film positioned across a top surface of a container, the portion including a center portion in which the at least one item is placed. Air may be extracted from the container to create a vacuum within the cavity and to expand the center portion to create a void in the center portion within the cavity. Air may flow into the container to release the vacuum and contract the center portion of the elastic film as the void is decreased and eliminated.

Abstract: A sortation system uses short conveyors or transporter units on a lift to move products or packages to totes in a storage rack. The lift may be a carousel. Automated components remove the totes from the rack and place them on outfeed conveyors. The system to remove the totes can include a transfer vehicle. The sortation system may be modular.

Abstract: A cable chain retraction system for a robot has a constant force on the cable chain because of the use of constant force springs cartridges. Spring cartridges may be added or subtracted to adjust the spring force on the cable chain. All components may be pre-installed on a rail, such as a quick release guiderail.

Abstract: A sortation system uses short conveyors or transporter units on a lift to move products or packages to totes in a storage rack. The lift may be a carousel. Automated components remove the totes from the rack and place them on outfeed conveyors. The system to remove the totes can include a transfer vehicle. The sortation system may be modular.

Abstract: The present intervention generally relates to compositions comprising a PDE11 inhibitor for increasing cortisol levels in a subject, or for increasing the production of cortisol from adenocortical cells in a subject. Aspects of the invention relate to the use of a PDE11 inhibitor in a method of treatment of low cortisol levels and/or adrenal insufficiency in a subject, or a method of treating a disease or disorders associated with adrenal insufficiency. Aspects of the invention relate to PDE11 inhibitors belonging to compounds of formula (I)-(VI), and their use alone or in combination with long-term corticosteroid treatment to elevate cortisol levels in a subject, and/or to treat adrenal insufficiency.

Abstract: The present intervention generally relates to compositions comprising a PDE11 inhibitor for increasing cortisol levels in a subject, or for increasing the production of cortisol from adenocortical cells in a subject. Aspects of the invention relate to the use of a PDE11 inhibitor in a method of treatment of low cortisol levels and/or adrenal insufficiency in a subject, or a method of treating a disease or disorders associated with adrenal insufficiency. Aspects of the invention relate to PDE11 inhibitors belonging to compounds of formula (I)-(VI), and their use alone or in combination with long-term corticosteroid treatment to elevate cortisol levels in a subject, and/or to treat adrenal insufficiency.

Abstract: Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a two-level dosing regime of progesterone. In one method, a subject in need thereof is administered at least one cycle of therapy, wherein the cycle of therapy comprises administering a therapeutically effective two-level intravenous dosing regime of progesterone. The two-level dosing regime comprises a first time period, wherein a higher hourly dose of progesterone is administered to the subject, followed by a second time period, wherein a lower hourly dose of progesterone is administered to the subject.

Abstract: Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a two-level dosing regime of progesterone. In one method, a subject in need thereof is administered at least one cycle of therapy, wherein the cycle of therapy comprises administering a therapeutically effective two-level intravenous dosing regime of progesterone. The two-level dosing regime comprises a first time period, wherein a higher hourly dose of progesterone is administered to the subject, followed by a second time period, wherein a lower hourly dose of progesterone is administered to the subject.

Abstract: Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a two-level dosing regime of progesterone. In one method, a subject in need thereof is administered at least one cycle of therapy, wherein the cycle of therapy comprises administering a therapeutically effective two-level intravenous dosing regime of progesterone. The two-level dosing regime comprises a first time period, wherein a higher hourly dose of progesterone is administered to the subject, followed by a second time period, wherein a lower hourly dose of progesterone is administered to the subject.

Abstract: The present invention provides methods for conferring a neuroprotective effect on a population of cells in a subject following a traumatic injury to the central nervous system. Specifically, the methods of the invention provide for the administration of a progestin or progestin metabolite following a traumatic brain injury. The progestin or progestin metabolite is administered at therapeutically effective concentrations that produce a neuroprotective effect (i.e., a decrease in the loss of neuronal activity) and reduces and/or prevents the various physiological events leading to neurodegeneration, such as, cerebral edema and the immune/inflammatory response.

Abstract: A flexible billing system and method of managing the billing needs of both customers and users. Billing events such as telephone calls are logged and stored by a computer. These events are then accessed by the billing system and associated with customers. Customers are billed based on the pricing rule they are associated with. Bills may then be created according to the bill format the customer is associated with and the customers is then invoiced.