Patents by Inventor Stuart Isaacs

Stuart Isaacs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transmission blocking immunogen from malaria
    Patent number: 6780417
    Abstract: The present invention relates to transmission blocking vaccines against malaria. Vaccines of the present invention contain a recombinant virus encoding all, or a unique portion, of the 25 kDa sexual stage surface protein of Plasmodium falciparum, Pfs25, or the Pfs25 protein purified from host cells infected with the above-described recombinant virus. Mice inoculated with the recombinant virus developed antibodies with transmission blocking activity. The present invention also relates to recombinant viruses used in the vaccines of the present invention, host cells infected with the recombinant viruses of the present invention and methods of preventing or treating malarial infections using the vaccines of the present invention.
    Type: Grant
    Filed: March 2, 1995
    Date of Patent: August 24, 2004
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: David C. Kaslow, Stuart Isaacs, Bernard Moss
  • TRANSMISSION BLOCKING VACCINE AGAINST MALARIA
    Publication number: 20030049278
    Abstract: The present invention relates to transmission blocking vaccines against malaria. Vaccines of the present invention contain a recombinant virus encoding all, or a unique portion, of the 25 kDa sexual stage surface protein of Plasmodium falciparum, Pfs25, or the Pfs25 protein purified from host cells infected with the above-described recombinant virus. Mice inoculated with the recombinant virus developed antibodies with transmission blocking activity. The present invention also relates to recombinant viruses used in the vaccines of the present invention, host cells infected with the recombinant viruses of the present invention and methods of preventing or treating malarial infections using the vaccines of the present invention.
    Type: Application
    Filed: March 2, 1995
    Publication date: March 13, 2003
    Inventors: DAVID C. KASLOW, STUART ISAACS, BERNARD MOSS