Patents by Inventor Stuart J. Knechtle

Stuart J. Knechtle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunosuppression using piceatannol and a calcineurin inhibitor
    Publication number: 20040033941
    Abstract: Disclosed herein are methods and drugs for suppressing acute/chronic rejection responses of a transplant recipient. Piceatannol and calcineurin inhibitors such as cyclosporin A and FK506 are administered in a combined protocol shortly before, and/or after, the transplant. They can be injected in an organic solvent, or other carrier.
    Type: Application
    Filed: February 28, 2003
    Publication date: February 19, 2004
    Inventors: Majed M. Hamawy, Stuart J. Knechtle
  • PROCESS OF DELIVERING A POLYNUCLEOTIDE TO A MUSCLE CELL VIA THE VASCULAR SYSTEM
    Publication number: 20020001574
    Abstract: A process for delivering a polynucleotide into a parenchymal cell in a mammal, comprising, transporting the polynucleotide into a blood vessel communicating with the parenchymal cell in tissue or organ of the mammal such that the polynucleotide is transfected into the parenchymal cell. More specifically, the parenchymal cell consists of a muscle cell and the polynucleotide consists of a viral vector.
    Type: Application
    Filed: December 30, 1997
    Publication date: January 3, 2002
    Inventors: JON A. WOIFF, STUART J. KNECHTLE, VLADIMIR BUDKER
  • PROCESS OF DELIVERING A POLYNUCLEOTIDE TO A CELL VIA THE VASCULAR SYSTEM
    Publication number: 20010009904
    Abstract: A process for delivering a polynucleotide into a parenchymal cell in a mammal, comprising, transporting the polynucleotide into a blood vessel communicating with the parenchymal cell in tissue or organ of the mammal such that the polynucleotide is transfected into the parenchymal cell. More specifically, the parenchymal cell consists of a parenchymal cell and the polynucleotide consists of a viral vector.
    Type: Application
    Filed: April 30, 1998
    Publication date: July 26, 2001
    Inventors: JON A. WOLFF, STUART J. KNECHTLE, VLADIMIR G. BUDKER
  • Process of delivering naked DNA into a hepatocyte via bile duct
    Patent number: 6265387
    Abstract: A process for delivering a polynucleotide to a parenchymal cell in a mammal by injecting the polynucleotide into a blood vessel connected to the parenchymal cell in tissue or organ of the mammal such that the polynucleotide is transfected into the parenchymal cell and functionally expressed to therapeutic levels.
    Type: Grant
    Filed: November 21, 1997
    Date of Patent: July 24, 2001
    Assignee: Mirus, Inc.
    Inventors: Jon A. Wolff, Vladimir Budker, Stuart J. Knechtle
  • PROCESS OF DELIVERING A POLYNUCLEOTIDE INTO A PARENCHYMAL CELL
    Publication number: 20010008882
    Abstract: A process for delivering a polypeptide into a parenchymal cell in a mammal, comprising, transporting the polynucleotide into a blood vessel communicating with the parenchymal cell in tissue or organ of the mammal such that the polynucleotide is transfected into the parenchymal cell.
    Type: Application
    Filed: September 7, 1999
    Publication date: July 19, 2001
    Inventors: JON A. WOLFF, VLADIMIR BUDKER, STUART J. KNECHTLE
  • Assessing immunological state of transplant recipients
    Patent number: 6150121
    Abstract: Disclosed herein are methods for monitoring the immunological status of transplant recipients. Fibroblast cells derived from transplanted organs are used in proliferation assays with lymphocytes taken from the recipient after transplantation. The comparison of assay results in the presence of, and in the absence of (or in the presence of reduced levels of) a cytokine growth factor such as interleukin-2, is used to determine whether the organ is being rejected. Also disclosed are kits for practicing these methods.
    Type: Grant
    Filed: February 16, 1999
    Date of Patent: November 21, 2000
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Majed M. Hamawy, Stuart J. Knechtle
  • Thymus tolerance in primates
    Patent number: 5762927
    Abstract: Disclosed is a method of inhibiting a rejection response by a primate to a transplanted organ. One exposes the primate to a mutant diphtheria toxin linked to anti-CD3 antibody so as to largely eliminate the host's peripheral blood T cell lymphocyte population. At the same time as, or after, the exposure step one administers to the primate's thymus gland donor lymphocytes. Transplantation of the organ follows. The primate is tolerized to the transplanted organ.
    Type: Grant
    Filed: April 11, 1997
    Date of Patent: June 9, 1998
    Assignees: Wisconsin Alumni Research Foundation, David M. Neville, Jr.
    Inventors: Stuart J. Knechtle, Jue Wang, Jon A. Wolff, David M. Neville, Jr.