Patents by Inventor Stuart J Mickel

Stuart J Mickel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of renin inhibitors involving a cycloaddition reaction
    Patent number: 7973175
    Abstract: The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a compound of the formula III, wherein R, R1, and R? are as defined in the specification, or a salt thereof, and a compound of formula IV wherein R, R1, R2 and R? are as defined in the specification, and processes of manufacturing these.
    Type: Grant
    Filed: September 26, 2006
    Date of Patent: July 5, 2011
    Assignee: Novartis AG
    Inventors: Stuart J Mickel, Wolfgang Marterer
  • Process for preparing renin inhibitors
    Patent number: 7767831
    Abstract: The present invention provides a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention provides a process for the manufacture of a compound of the formula III, wherein R, R1, R2, R3 and PG are as defined in the specification, or a salt thereof. The manufacture comprises (preferably consists of) reacting a compound of the formula I, with a reagent able to transform hydroxy into X where X is for example a leaving group.
    Type: Grant
    Filed: June 6, 2006
    Date of Patent: August 3, 2010
    Assignee: Novartis AG
    Inventors: Stuart J Mickel, Gottfried Sedelmeier, Hans Hirt, Frank Schäfer, Michael Foulkes, Walter Prikoszovich
  • Metabotropic GABA receptors, receptor-specific ligands and their uses
    Patent number: 7119189
    Abstract: The present invention provides purified GABAB receptors and receptor proteins derived from rat and human sources, as well as nucleic acids which encode such proteins. The proteins and nucleic acids of the invention share significant homology with the GABAB receptor and the DNA encoding it as specifically disclosed herein. The invention moreover provides methods for isolating other members of the GABAB receptor family using DNA cloning technology and probes derived from the sequences provided herein, as well as novel members of the GABAB receptor family isolated by such methods.
    Type: Grant
    Filed: June 6, 2001
    Date of Patent: October 10, 2006
    Assignee: Novartis AG
    Inventors: Klemens Kaupmann, Bernhard Bettler, Helmut Bittiger, Wolfgang Fröstl, Stuart J Mickel