Abstract: Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices, that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices comprise a unique microarchitectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.

Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous and subcutaneous measurement of glucose in a host.

Abstract: An implantable analyte-measuring device including a membrane adapted to promote vascularization and/or interfere with barrier cell layer formation. The membrane includes any combination of materials, architecture, and bioactive agents that facilitate analyte transport to provide long-term in vivo performance of the implantable analyte-measuring device.

Abstract: An implantable analyte-measuring device including a membrane adapted to promote vascularization and/or interfere with barrier cell layer formation. The membrane includes any combination of materials, architecture, and bioactive agents that facilitate analyte transport to provide long-term in vivo performance of the implantable analyte-measuring device.

Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous and subcutaneous measurement of glucose in a host.

Abstract: Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices include unique architectural arrangement in the sensor region that slows accurate date to be obtained over long periods of time.

Abstract: Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices, that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices comprise a unique microarchitectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.

Abstract: Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices include unique architectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.

Abstract: Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices, that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices comprise a unique microarchitectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.

Abstract: Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices, that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices comprise a unique microarchitectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.

Abstract: Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices include unique architectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.

Abstract: Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices, that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices comprise a unique microarchitectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.

Abstract: A biological fluid measuring device for determining the presence and the amounts of substances in a biological fluid without the need for dilution of the fluid comprises a main housing including electronic circuit means and at least one electrode, and a cartridge having a membrane. The cartridge is removably mounted on the housing and the membrane is maintained operably associated by osmotic pressure with the electrode. The cartridge also includes means for protecting the membrane when the device is not in use. An enzyme electrode is also disclosed comprising a multilayered homogeneous monolithic membrane and an intermediate water-swellable coating.

Abstract: A biological fluid measuring device for determining the presence and the amounts of substances in a biological fluid without the need for dilution of the fluid comprises a main housing including electronic circuit means and at least one elecrode, and a cartridge having a membrane. The cartridge is removably mounted on the housing and the membrane is operably associated with the electrode. The cartridge also includes means for protecting the membrane when the device is not in use.

Abstract: A device comprising a container and a threaded rotatable plunger mechanism including means for controllably advancing the plunger through the container can administer a precise dose of a drug-containing fluid subcutaneously at regular intervals. The means for controllably advancing the plunger comprises a drive tube concentrically mounted about a threaded rod operating within the container, the drive tube having ramp means at the upper end thereof, a ratchet head including a resilient member in operative communication with the upper end of the drive tube and a rotatable knob adjacent the ratchet head whereby rotation of the knob in one direction rotates the drive tube and the threaded rod to deliver the fluid through an outlet of the container.

Abstract: A method for monitoring blood glucose levels at frequent intervals, which includes a method for equalizing the temperature and oxygen level in the blood and sensing the rate of oxygen consumption by the glucose contained in the blood in the presence of glucose oxidase enzyme immobilized on a hydrophobic membrane covering a measurement electrode and elements employed therein including the equalizing method and the electrode and method for preparing same.

Abstract: A method and device for immunological determinations wherein the device comprises a container housing a volume of dry, insoluble, yet highly hydrophilic, gel particles, containing binding protein or combinations of binding protein and radio-active tag material and in which the dry gel particles are characterized by pores of a size that permit entry of low molecular weight components into the intra gel volume but insufficient to permit entry of large molecular weight components which remain in the extra gel volume.

Abstract: A semi-permeable membrane containing a catalyst for conversion of hydrogen peroxide introduced from one side of the semi-permeable membrane to molecular oxygen which is released from the opposite side of the semi-permeable membrane. The catalyst is preferably in the form of a ruthenium oxide or sulfide and preferably in assymetrical distribution in the membrane.

Abstract: A method for immunological determinations in which use is made of a volume of a hydrophilic, insoluble, porous gel particles having binding proteins entrapped therein, and in which a fluid to be tested is introduced into the volume of gel particles whereby some of the binding sites are occupied followed by exposure of the gel particles to radio active tagged material followed by measurement of the radio activity of the unbound or bound tagged material. The binding proteins in the gel particles are returned to their original state for re-use by treatment with acidic medium to effect detachment of the bound material followed by washing to effect removal of the unbound material, and then drying.

Abstract: The removal of carbon dioxide from blood plasma by transport through a dialysis membrane in the form of bicarbonate ion, in which the electrolyte supplies hydroxyl ion for transport back through the membrane for maintaining normal blood pH.