Abstract: A method comprising: receiving a request to write data at a virtual location; writing the data to a physical location on a persistent storage device; and recording a mapping from the virtual location to the physical location; wherein the physical location corresponds to a next free block in a sequence of blocks on the persistent storage device.

Abstract: A computer implemented method for characterizing one or more sequences by generating index values representing portions of the sequences and finding characterizing index values based on a comparison of the index values. The index values may be obtained by applying one or more mask over each sequence. The modified masks may have associated weightings and index values obtained using modified masks may be retained in the index only if the weightings are above a threshold value. Characterising index values may also be assessed for for their degree of uniqueness. Characterizing indexes may be used for predicting correlation between a sample sequence and one or more reference sequences. Biological monitoring systems utilising the characterizing index values are also disclosed. A biological indicator may be generatgenerated using one or more characterizing index values obtained by the above method and be used to produce an indicator that undergoes a property change in the presence of the one or more sequence.

Abstract: A method of evaluating correlation between sequences by employing a hierarchy of evaluation algorithms. The evaluation algorithms may be arranged in order of computational efficiency as specified by a user or as determined by the system. The algorithms may range from a simple equality algorithm through to seeded alignment algorithms etc. Distributed and parallel processing systems may be employed in the method of the invention in graphical processing units may be employed. The method may be employed with a wide range of sequencers including sequencers produced by Illumina Inc Complete Genomics Inc. and Pacific Biosciences Inc.

Abstract: Methods and systems for evaluating genomic sequences are described. The methods include approaches for evaluating the prevalence of genomes in a sample based on the prevalence of segments in the sample, and may additionally rely on the prevalence of segments in reference genomes and an estimated genome population distribution of the sample.

Abstract: A method and system are provided for evaluating the correlation between sequences by entering segments of one sequence in a database and comparing segments of the other sequence with the index values to find correlated segments. The correlated segments are analysed to determine whether the spacing is within a defined range indicating that a correlation threshold has been met. A processing methodology may be employed whereby a coarse potential alignment algorithm is first applied to determine potential alignment at a plurality of potential alignment positions, which are filtered based on alignment scores, and a fine alignment algorithm is then applied.

Abstract: A method of evaluating correlation between sequences by employing a hierarchy of evaluation algorithms. The evaluation algorithms may be arranged in order of computational efficiency as specified by a user or as determined by the system. The algorithms may range from a simple equality algorithm through to seeded alignment algorithms etc. Distributed and parallel processing systems may be employed in the method of the invention in graphical processing units may be employed. The method may be employed with a wide range of sequencers including sequencers produced by Illumina Inc Complete Genomics Inc. and Pacific Biosciences Inc.

Abstract: A method of cataloguing a data structure employs the formation of a catalogue data structure which is used to associate data items transformed from data elements present within the data collection with storage addresses of the original transformed data elements. This catalogue data structure may be sorted to facilitate searching through same to detect the presence of search patterns. Such searches may be completed through the formation of a plurality of search queries from a received search pattern sequence where the results of running these search queries may then be subsequently considered in conjunction with a search pattern sequence detection process.

Abstract: The present invention relates to a method of cataloguing a data structure and also preferably a method of searching through such as data structure to detect the presence of search patterns within the data structure. The catalogusing method of the present invention employs the formation of a catalogue data structure which is used to associate data items (transformed from data elements present within the data collection) with storage addresses. This catalogue data structure may be sorted to facilitate searching through same. Such searches may be completed through the formation of a plurality of search quries from a received search pattern sequence where the results of running these search queries may then be subsequently considered in conjunction with a search pattern sequence detection process.