Patents by Inventor Stuart Knechtle
Stuart Knechtle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10060930Abstract: The present invention relates to methods of diagnosing, predicting and monitoring kidney disorders. In particular, the present invention relates to the diagnosis, prediction and monitoring of kidney disorders by detection of cytokines, cytokine-related compounds and chemokines in urine. The present invention further relates to methods and compositions for assessing the efficacy of agents and interventions used to treat kidney disorders.Type: GrantFiled: January 4, 2016Date of Patent: August 28, 2018Assignee: Renovar IncorporatedInventors: Huaizhong Hu, Stuart Knechtle
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Publication number: 20160116484Abstract: The present invention relates to methods of diagnosing, predicting and monitoring kidney disorders. In particular, the present invention relates to the diagnosis, prediction and monitoring of kidney disorders by detection of cytokines, cytokine-related compounds and chemokines in urine. The present invention further relates to methods and compositions for assessing the efficacy of agents and interventions used to treat kidney disorders.Type: ApplicationFiled: January 4, 2016Publication date: April 28, 2016Inventors: Huaizhong HU, Stuart KNECHTLE
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Patent number: 9229011Abstract: The present invention relates to methods of diagnosing, predicting and monitoring kidney disorders. In particular, the present invention relates to the diagnosis, prediction and monitoring of kidney disorders by detection of cytokines, cytokine-related compounds and chemokines in urine. The present invention further relates to methods and compositions for assessing the efficacy of agents and interventions used to treat kidney disorders.Type: GrantFiled: April 20, 2012Date of Patent: January 5, 2016Assignee: RENOVAR INCORPORATEDInventors: Huaizhong Hu, Stuart Knechtle
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Publication number: 20150011419Abstract: The present invention provides systems and methods for characterizing biological markers in the urine of systemic lupus erythematosus (SLE) subjects. In particular, the present invention relates to the detection of cytokines and chemokines in urine of SLE subjects for determining nephritic disease states and kidney damage in SLE subjects and the efficacy of agents and interventions used to treat lupus nephritis.Type: ApplicationFiled: September 25, 2014Publication date: January 8, 2015Inventors: Ganesh Vasudevan, Huaizhong Hu, Stuart Knechtle
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Publication number: 20120208717Abstract: The present invention relates to methods of diagnosing, predicting and monitoring kidney disorders. In particular, the present invention relates to the diagnosis, prediction and monitoring of kidney disorders by detection of cytokines, cytokine-related compounds and chemokines in urine. The present invention further relates to methods and compositions for assessing the efficacy of agents and interventions used to treat kidney disorders.Type: ApplicationFiled: April 20, 2012Publication date: August 16, 2012Applicant: RENOVAR INCORPORATEDInventors: Huaizhong Hu, Stuart Knechtle
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Publication number: 20110236912Abstract: The present invention provides systems and methods for characterizing biological markers in the urine of systemic lupus erythematosus (SLE) subjects. In particular, the present invention relates to the detection of cytokines and chemokines in urine of SLE subjects for determining nephritic disease states and kidney damage in SLE subjects and the efficacy of agents and interventions used to treat lupus nephritis.Type: ApplicationFiled: November 3, 2009Publication date: September 29, 2011Applicant: Renovar, Inc.Inventors: Ganesh Vasudevan, Huaizhong Hu, Stuart Knechtle
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Publication number: 20090197287Abstract: The present invention relates to methods of diagnosing, predicting and monitoring kidney disorders. In particular, the present invention relates to the diagnosis, prediction and monitoring of kidney disorders by detection of cytokines, cytokine-related compounds and chemokines in urine. The present invention further relates to methods and compositions for assessing the efficacy of agents and interventions used to treat kidney disorders.Type: ApplicationFiled: December 8, 2008Publication date: August 6, 2009Applicant: RENOVAR INCORPORATEDInventors: Huaizhong Hu, Stuart Knechtle
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Patent number: 7476497Abstract: The present invention relates to methods of diagnosing, predicting and monitoring kidney disorders. In particular, the present invention relates to the diagnosis, prediction and monitoring of kidney disorders by detection of cytokines, cytokine-related compounds and chemokines in urine. The present invention further relates to methods and compositions for assessing the efficacy of agents and interventions used to treat kidney disorders.Type: GrantFiled: November 21, 2006Date of Patent: January 13, 2009Assignee: Renovar IncorporatedInventors: Huaizhong Hu, Stuart Knechtle
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Publication number: 20080206794Abstract: The present invention relates to methods of diagnosing, predicting and monitoring kidney disorders. In particular, the present invention relates to the diagnosis, prediction and monitoring of contrast-induced nephropathy by detection of cytokines, cytokine-related compounds, and chemokines in urine. The present invention further relates to methods and compositions for assessing the efficacy of agents and interventions used to treat contrast-induce nephropathy.Type: ApplicationFiled: September 17, 2007Publication date: August 28, 2008Applicant: Renovar IncorporatedInventors: Huaizhong Hu, Stuart Knechtle
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Publication number: 20070249002Abstract: The present invention relates to methods of diagnosing, predicting and monitoring kidney disorders. In particular, the present invention relates to the diagnosis, prediction and monitoring of kidney disorders by detection of cytokines, cytokine-related compounds and chemokines in urine. The present invention further relates to methods and compositions for assessing the efficacy of agents and interventions used to treat kidney disorders.Type: ApplicationFiled: November 21, 2006Publication date: October 25, 2007Applicant: Renovar IncorporatedInventors: Huaizhong Hu, Stuart Knechtle
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Systems and methods for monitoring immune responses and predicting outcomes in transplant recipients
Publication number: 20070202085Abstract: The present invention is related to transplant rejection. In particular, the present invention relates to determining the functional status of alloreactive T cells and correlating the functional status to in vivo immune responses (e.g., tolerance, rejection, or absence of rejection mediated by T cells). The present invention finds use in basic research, clinical (e.g., transplant) and therapeutic settings.Type: ApplicationFiled: January 16, 2007Publication date: August 30, 2007Applicant: Renovar IncorporatedInventors: Huaizhong Hu, Stuart Knechtle, Jean Kwun -
Publication number: 20070134728Abstract: The present invention relates to methods of diagnosing, predicting and monitoring conditions and disorders associated organ transplantation and organ health. In particular, the present invention relates to the diagnosis, prediction and monitoring of disorders, conditions, and organ status by detection of cytokines, cytokine-related compounds, and chemokines, particularly in urine. The present invention further relates to methods and compositions for assessing the efficacy of agents and interventions used to treat organ associated disorders and conditions and for maintaining organ health.Type: ApplicationFiled: October 25, 2006Publication date: June 14, 2007Applicant: Renovar IncorporatedInventors: Huaizhong Hu, Stuart Knechtle
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Patent number: 7138230Abstract: The present invention relates to methods of diagnosing, predicting and monitoring kidney disorders. In particular, the present invention relates to the diagnosis, prediction and monitoring of kidney disorders by detection of cytokines, cytokine-related compounds and chemokines in urine. The present invention further relates to methods and compositions for assessing the efficacy of agents and interventions used to treat kidney disorders.Type: GrantFiled: December 13, 2004Date of Patent: November 21, 2006Assignee: Renovar, Inc.Inventors: Huaizhong Hu, Stuart Knechtle, Brian D. Aizenstein
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Patent number: 7138229Abstract: The present invention relates to methods of diagnosing, predicting and monitoring kidney diseases, including acute renal failure, renal tubular interstitial disease and glomerulonephritis. In particular, the present invention relates to the detection, prediction and monitoring of kidney diseases by detection of CXCR3 and CCL chemokines in urine. The present invention further relates to methods and compositions for assessing the efficacy of agents and interventions used to treat kidney diseases.Type: GrantFiled: July 30, 2004Date of Patent: November 21, 2006Assignee: Renovar, Inc.Inventors: Huaizhong Hu, Stuart Knechtle
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Patent number: 7125553Abstract: Provided is a method of treating an immune system disorder not involving T cell proliferation, comprising administering to the animal an immunotoxin comprising a mutant diphtheria toxin moiety linked to an antibody moiety which routes by the anti-CD3 pathway, or derivatives thereof under conditions such that the disorder is treated. Thus, the present method can treat graft-versus-host disease.Type: GrantFiled: August 26, 1999Date of Patent: October 24, 2006Assignees: The United States of America as represented by the Department of Health and Human Services c/o Centers for Disease Control and Prevention, The UAB Research FoundationInventors: David M. Neville, Stuart Knechtle, Judith M. Thomas
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Publication number: 20050158801Abstract: The present invention relates to methods of diagnosing, predicting and monitoring kidney disorders. In particular, the present invention relates to the diagnosis, prediction and monitoring of kidney disorders by detection of cytokines, cytokine-related compounds and chemokines in urine. The present invention further relates to methods and compositions for assessing the efficacy of agents and interventions used to treat kidney disorders.Type: ApplicationFiled: December 13, 2004Publication date: July 21, 2005Inventors: Huaizhong Hu, Stuart Knechtle, Brian Aizenstein
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Publication number: 20050112688Abstract: The present invention relates to methods of diagnosing, predicting and monitoring kidney diseases, including acute renal failure, renal tubular interstitial disease and glomerulonephritis. In particular, the present invention relates to the detection, prediction and monitoring of kidney diseases by detection of CXCR3 and CCL chemokines in urine. The present invention further relates to methods and compositions for assessing the efficacy of agents and interventions used to treat kidney diseases.Type: ApplicationFiled: July 30, 2004Publication date: May 26, 2005Inventors: Huaizhong Hu, Stuart Knechtle
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Patent number: 6103235Abstract: Provided is a method of treating an immune system disorder not involving T cell proliferation, comprising administering to the animal an immunotoxin comprising a mutant diphtheria toxin moiety linked to an antibody moiety which routes by the anti-CD3 pathway, or derivatives thereof under conditions such that the disorder is treated. Thus, the present method can treat graft-versus-host disease.Type: GrantFiled: April 15, 1997Date of Patent: August 15, 2000Assignees: The United States of America as represented by the Department of Health and Human Services, The UAB Research FoundationInventors: David M. Neville, Stuart Knechtle