Patents by Inventor Stuart Kornfeld

Stuart Kornfeld has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions comprising a modified GIcNAc-1-phosphotransferase and methods of use thereof
    Patent number: 11732249
    Abstract: The disclosure provides a modified UDP-GlcNAc:Lysosomal Enzyme GlcNAc phosphotransferase with enhanced ability to phosphorylate lysosomal enzymes and methods of use thereof.
    Type: Grant
    Filed: December 17, 2020
    Date of Patent: August 22, 2023
    Assignee: Washington University
    Inventors: Stuart Kornfeld, Lin Liu, Wang Lee, Balraj Doray
  • COMPOSITIONS COMPRISING A MODIFIED GIcNAc-1-PHOSPHOTRANSFERASE AND METHODS OF USE THEREOF
    Publication number: 20210180035
    Abstract: The disclosure provides a modified UDP-GlcNAc:Lysosomal Enzyme GlcNAc-1-phosphotransferase with enhanced ability to phosphorylate lysosomal enzymes and methods of use thereof.
    Type: Application
    Filed: December 17, 2020
    Publication date: June 17, 2021
    Applicant: Washington University
    Inventors: Stuart Kornfeld, Lin Liu, Wang Lee, Balraj Doray
  • Compositions comprising a modified GIcNAc-1-phosphotransferase and methods of use thereof
    Patent number: 10907139
    Abstract: The disclosure provides a modified UDP-GlcNAc:Lysosomal Enzyme GlcNAc-1-phosphotransferase with enhanced ability to phosphorylate lysosomal enzymes and methods of use thereof.
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: February 2, 2021
    Inventors: Stuart A. Kornfeld, Balraj Doray, Wang Lee, Lin Liu
  • COMPOSITIONS COMPRISING A MODIFIED GlcNAc-1-PHOSPHOTRANSFERASE AND METHODS OF USE THEREOF
    Publication number: 20190225953
    Abstract: The disclosure provides a modified UDP-GlcNAc:Lysosomal Enzyme GlcNAc-1-phosphotransferase with enhanced ability to phosphorylate lysosomal enzymes and methods of use thereof.
    Type: Application
    Filed: October 2, 2017
    Publication date: July 25, 2019
    Inventors: Stuart A. Kornfeld, Balraj Doray, Wang Lee, Lin Liu
  • Expression of lysosomal hydrolase in cells expressing pro-N-acetylglucosamine-1-phosphodiester ?-N-acetyl glucosimanidase
    Patent number: 7135322
    Abstract: The present invention provides methods of producing a pro-N-acetylglucosamine-1-phosphodiester?N-acetyl glucosimanidase (phosphodiester ?-GlcNAcase), in mammalian cells deficient in the furin proteolytic enzyme and methods of making lysosomal bydrolases having an N-acetylglucosamine-1-phosphate.
    Type: Grant
    Filed: July 29, 2004
    Date of Patent: November 14, 2006
    Assignee: Novazyme Pharmaceuticals, Inc.
    Inventors: William Canfield, Stuart Kornfeld
  • Expression of lysosomal hydrolase in cells expressing pro-N-acetylglucosamine-1-phosphodiester alpha-N-acetyl glucosimanidase
    Publication number: 20050003486
    Abstract: The present invention provides methods of producing a pro-N-acetylglucosamine-1-phosphodiester ? N-acetyl glucosimanidase (phosphodiester ?-GlcNAcase), in mammalian cells deficient in the furin proteolytic enzyme and methods of making lysosomal bydrolases having an N-acetylglucosamine-1-phosphate.
    Type: Application
    Filed: July 29, 2004
    Publication date: January 6, 2005
    Applicant: Genzyme Glycobiology Research Institute, Inc.
    Inventors: William Canfield, Stuart Kornfeld
  • Expression of lysosomal hydrolase in cells expressing pro-N-acetylglucosamine-1-phosphodiester &agr;-N-acetyl glucosimanidase
    Patent number: 6800472
    Abstract: The present invention provides methods of producing a pro-N-acetylglucosamine-1-phosphodiester &agr; N-acetyl glucosimanidase (phosphodiester &agr;-GlcNAcase), in mammalian cells deficient in the furin proteolytic enzyme and methods of making lysosomal hydrolases having an N-acetylglucosamine-1-phosphate.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: October 5, 2004
    Assignee: Genzyme Glycobiology Research Institute, Inc.
    Inventors: William Canfield, Stuart Kornfeld
  • Expression of lysosomal hydrolase in cells expressing pro-N-acetylglucosamine-1-phosphodiester alpha-N-acetyl glucosimanidase
    Publication number: 20030143669
    Abstract: The present invention provides methods of producing a pro-N-acetylglucosamine-1-phosphodiester &agr; N-acetyl glucosimanidase (phosphodiester &agr;-GlcNAcase), in mammalian cells deficient in the furin proteolytic enzyme and methods of making lysosomal hydrolases having an N-acetylglucosamine-1-phosphate.
    Type: Application
    Filed: December 21, 2001
    Publication date: July 31, 2003
    Applicant: NOVAZYME PHARMACEUTICALS, INC.
    Inventors: William Canfield, Stuart Kornfeld