Abstract: A lighting network includes a lighting network base station and one or more contactless lighting network components. The lighting network base station includes: a radio frequency (RF) amplifier which supplies an RF power signal to a lighting network line pair; and a first power line communication coupler which couples the lighting network line pair to a first power line communication device. The contactless lighting network component extracts electrical power from the RF power signal on the lighting network line pair, and couples the lighting network line pair to a second power line communication device. The first and second power line communication devices communicate network data via the lighting network line pair. The contactless lighting network component may include a lighting fixture (e.g., including one or more LED light sources), a sensor, and/or a lighting network interface adaptor.

Abstract: The present application is directed to heat sinks for light emitting devices. In particular, the heat sinks can provide effective heat dissipation in a variety of different orientations and positions. In one exemplary heat sink, different groups (110, 120, 130, 140) of essentially parallel fins (112, 122, 132, 142) can be separated and disposed at particular angles to form fluid channels (114, 124, 134, 144, 108 and 109) that enable fluid flow in different directions and orientations.

Abstract: A lighting network includes a lighting network base station and one or more contactless lighting network components. The lighting network base station includes: a radio frequency (RF) amplifier which supplies an RF power signal to a lighting network line pair; and a first power line communication coupler which couples the lighting network line pair to a first power line communication device. The contactless lighting network component extracts electrical power from the RF power signal on the lighting network line pair, and couples the lighting network line pair to a second power line communication device. The first and second power line communication devices communicate network data via the lighting network line pair. The contactless lighting network component may include a lighting fixture (e.g., including one or more LED light sources), a sensor, and/or a lighting network interface adaptor.

Abstract: The present application is directed to heat sinks for light emitting devices. In particular, the heat sinks can provide effective heat dissipation in a variety of different orientations and positions. In one exemplary heat sink, different groups (110, 120, 130, 140) of essentially parallel fins (112, 122, 132, 142) can be separated and disposed at particular angles to form fluid channels (114, 124, 134, 144, 108 and 109) that enable fluid flow in different directions and orientations.

Abstract: Organic chelating ligands, organic chelating ligand precursors, and metal chelates are disclosed. Methods for synthesizing the same are also described, including methods for preparing optically-enriched or optically-pure compositions of the same.

Abstract: Organic chelating ligands, organic chelating ligand precursors, and metal chelates are disclosed. Methods for synthesizing the same are also described, including methods for preparing optically-enriched or optically-pure compositions of the same.

Abstract: Methods and compositions for treating Cryptosporidium parvum related disorders in a mammal are discussed. Several novel tetracycline compounds useful for treating Cryptosporidium parvum related disorders are also included.

Abstract: The crystal structure of the product, crystals of the MarR protein, a regulator of multiple antibiotic resistance in Escherichia coli, and methods of crystallization of the MarR protein are described.

Abstract: The instant methods and compositions represent an advance in controlling drug resistance in microbes. AcrAB-like efflux pumps have been found to control resistance to drugs, even in highly resistant microbes. Accordingly, methods of treating infection, methods of screening for inhibitors of AcrAB-like efflux pumps, and methods of enhancing antimicrobial activity of drugs are provided. Pharmaceutical composition comprising an inhibitor of an AcrAB-like efflux pump and an antimicrobial agent are also provided.

Abstract: Methods and compounds for treating diseases with tetracycline compounds having a target therapeutic activity are described.

Abstract: Organic chelating ligands, organic chelating ligand precursors, and metal chelates are disclosed. Methods for synthesizing the same are also described, including methods for preparing optically-enriched or optically-pure compositions of the same.

Abstract: Methods for identifying MarR family inhibiting compounds are described. The methods include the use of computer aided rational based drug design programs and three dimensional structures of MarR family polypeptides.

Abstract: The instant methods and compositions represent an advance in controlling drug resistance in microbes. AcrAB-like efflux pumps have been found to control resistance to drugs, even in highly resistant microbes. Accordingly, methods of treating infection, methods of screening for inhibitors of AcrAB-like efflux pumps, and methods of enhancing antimicrobial activity of drugs are provided. Pharmaceutical composition comprising an inhibitor of an AcrAB-like efflux pump and an antimicrobial agent are also provided.

Abstract: The invention includes new substituted tetracycline-type compounds that exhibit significant antibacterial activity, including against both gram-positive and gram-negative bacteria. It has been found that compounds of the invention are highly active against both gram positive and gram negative tetracycline sensitive and tetracycline resistant bacteria.