Abstract: Lipid particles containing a nucleic acid, devices and methods for making the lipid particles, and methods for using the lipid particles.

Abstract: Lipid particles containing a nucleic acid, devices and methods for making the lipid particles, and methods for using the lipid particles.

Abstract: Lipid particles containing a nucleic acid, devices and methods for making the lipid particles, and methods for using the lipid particles.

Abstract: An apparatus for simulation of an endoscopy operation. A dummy endoscope (1) is inserted into a unit (2) which monitors the position of the dummy instrument and provides force feedback to the instrument in accordance with a stored software model. A virtual image simulating the view from the endoscope is displayed. Additional simulation is provided of an external condition to the patient body, for example patient orientation (8), external pressure applied to the body (9), (10) and trans-illumination (11).

Abstract: Lipid particles containing a nucleic acid, devices and methods for making the lipid particles, and methods for using the lipid particles.

Abstract: A door check including an arm with an arm mount is provided for mounting the arm to a vehicle door or frame. The arm includes a first surface and an oppositely disposed second surface. The door check further includes an arm guide including a housing, including a guide mount for mounting the housing to the vehicle door or frame, and a guideway for receiving the arm. The arm guide also includes two generally facing arm engaging structures mounted within the housing for receiving the arm therebetween. Each arm engaging structure faces its respective arm surface. The arm guide includes a spring between the housing and the second arm engaging structure. The spring biases that structure towards the first arm engaging structure to urge these structures into contact with the respective arm surfaces restricting longitudinal movement of the arm through the guideway.

Abstract: A method and a circuit to achieve a low drop-out voltage regulator with a wide output load range has been achieved. A fast loop is introduced in the circuit. The circuit is internally compensated and uses a capacitor to ensure that the internal pole is more dominant than the output pole as in standard Miller compensation. The quiescent current is set being proportional to the output load current. No explicit low power drive stage is required. The whole output range is covered by one output drive stage. By that means the total consumption of quiescent or wasted current is reduced. An excellent PSRR is achieved due to load dependent bias current.

Abstract: An apparatus for simulation of an endoscopy operation. A dummy endoscope (1) is inserted into a unit (2) which monitors the position of the dummy instrument and provides force feedback to the instrument in accordance with a stored software model. A virtual image simulating the view from the endoscope is displayed. Additional simulation is provided of an external condition to the patient body, for example patient orientation (8), external pressure applied to the body (9), (10) and trans-illumination (11).

Abstract: A method and a circuit to achieve a low drop-out voltage regulator with a wide output load range has been achieved. A fast loop is introduced in the circuit. The circuit is internally compensated and uses a capacitor to ensure that the internal pole is more dominant than the output pole as in standard Miller compensation. The quiescent current is set being proportional to the output load current. No explicit low power drive stage is required. The whole output range is covered by one output drive stage. By that means the total consumption of quiescent or wasted current is reduced. An excellent PSRR is achieved due to load dependent bias current.

Abstract: A method and a circuit to monitor exactly the charge status of a battery of a battery powered device is achieved. The charge and discharge currents are continuously measured and integrated over time to get the exact charge of the battery. Inaccuracies caused by the offset of the integrators are precisely compensated by a bridge-like design of said circuit and by a feedback of said offset to the input of the integrators. The system is clocked in a way to enable a continuous operation. Another advantage is the low current consumption of the circuit by sharing some of the components for the integration of the currents and handling of the offset. The improved accuracy is optimizing the operation of said battery driven device and is avoiding any potential damage of the battery.

Abstract: A method and a circuit to monitor exactly the charge status of a battery of a battery powered device is achieved. The charge and discharge currents are continuously measured and integrated over time to get the exact charge of the battery. Inaccuracies caused by the offset of the integrators are precisely compensated by a bridge-like design of said circuit and by a feedback of said offset to the input of the integrators. The system is clocked in a way to enable a continuous operation. Another advantage is the low current consumption of the circuit by sharing some of the components for the integration of the currents and handling of the offset. The improved accuracy is optimizing the operation of said battery driven device and is avoiding any potential damage of the battery.

Abstract: 8-Azapurin-6-ones substituted in the 2-position by a phenyl group carrying in a meta-position a sulphamoyl substituent, and also a hydroxy, alkoxy or alkylthio substituent para with respect to the said sulphamoyl grouping, and pharmaceutically acceptable salts thereof, possess pharmacological properties useful in the treatment of allergic respiratory disorders, for example allergic bronchial asthma.

Abstract: The invention provides certain novel 8-azapurin-6-one derivatives substituted in the 2-position by a substituted phenyl group, preferably carrying an alkoxy in the 2-position, which possess valuable pharmacological properties especially in the treatment of respiratory disorders manifested by the interaction of tissue-fixed antibodies with specific antigens.

Abstract: 8-Azapurin-6-ones substituted in the 2-position by an unsubstituted or substituted phenyl or naphthyl group, or by an alkenyl or alkynyl group, a cycloalkyl group, an alkyl group contaning 2 to 10 carbon atoms, or an alkyl group containing 1 to 10 carbon atoms carrying one or more substitutents selected from halogen atoms and hydroxy, cycloalkyl, alkoxy, phenyl and substituted phenyl groups, and pharmaceutically acceptable salts thereof, possess pharmacological properties useful, for example, in the treatment of allergic bronchial asthma.

Abstract: 8-Azapurin-6-ones substituted in the 2-position by a phenyl group carrying in a meta-position a sulphamoyl substituent, and also a hydroxy, alkoxy or alkylthio substituent para with respect to the said sulphamoyl grouping, and pharmaceutically acceptable salts thereof, possess pharmacological properties useful in the treatment of allergic respiratory disorders, for example allergic bronchial asthma.