Abstract: The priming configuration comprises a piston rod (1), a bung (2), which is provided to be driven by the piston rod, and a movable element (5), which is engaged with the piston rod. The movable element is arranged to be movable in a predefined direction (10) with respect to the piston rod by a user of the drug delivery device. A movement of the movable element in the predefined direction advances the piston rod in a further direction (11), providing a priming of the drug delivery device before use. The predefined direction may especially be transverse to the further direction, and the further direction may especially be directed from the piston rod towards the bung (2). A gap (12) or clearance between the piston rod (1) and the bung (2) can thus be removed, and the stiction of the bung (2) to the cartridge (3) can be reduced.

Abstract: A display assembly is proposed, comprising: a body (4) defining a window (17) having an axial extension, an indication member (2) for providing information to be displayed in the window (17), wherein the indication member (2) is movable relative to the body (4) for changing the information displayed in the window (17), a selection member (3), wherein the selection member (3) defines a masking section (45) and a non-masking section (46), the selection member (3) is rotatable around a rotation axis (x) with respect to the body (4) and with respect to the indication member (2), the non-masking section (46) and the masking section (45) partially overlap with the window (17) to define a displayed section (52) of the indication member (2), and wherein the selection member (3) and the indication member (2) are coupled such that the displayed section (52) of the indication member (2) is axially displaced within the window (17).

Abstract: An assembly for a drug delivery device (200) is presented which comprises a housing (24) having a proximal end (25) and a distal end (26), a cartridge, a plunger (19) which is movably retained in the cartridge (14) and a piston rod (6). The assembly further comprises a rod displacement feature (33). The assembly is configured such that, in an initial state of the assembly, the piston rod (6) and the rod displacement feature (33) are arranged such that movement of the rod displacement feature (33) from the first position to the second position is transferred to the piston rod (6) such that the piston rod (6) is moved with respect to the cartridge (14) and the assembly is switched from the initial state to a primed state. In the primed state, movement of the rod displacement feature (33) from the first position to the second position is not transferred to the piston rod (6).

Abstract: The driving configuration for a drug delivery device comprises an energy storing member (2) providing a force suitable for driving a bung (1) arranged in a container (3), the bung being movable relative to the container. The energy storing member (2) is loaded by an alteration of its mechanical state with respect to a mounting element (5), which is relocatable in such a manner that a force provided by the energy storing member when it is loaded is reduced by a relocation of the mounting element.

Abstract: An indicator for a delivery device comprising a belt (71) having marks (73) for dose indication and/or status indication.

Abstract: The invention relates to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a dosing element (40, 30), which rotates in a first direction during dose selecting and rotates in a second, opposite direction during dose dispensing, and a display (60) for indicating the selected dose. The display (60) comprises at least one belt (61, 62) having symbols for indicating the selected dose and being coupled to the dosing element (40, 130) such that a rotation of the dosing element (40, 130) spools the belt (61, 62).

Abstract: A display assembly is proposed, comprising: a body (4) defining a window (17) having an axial extension, an indication member (2) for providing information to be displayed in the window (17), wherein the indication member (2) is movable relative to the body (4) for changing the information displayed in the window (17), a selection member (3), wherein the selection member (3) defines a masking section (45) and a non-masking section (46), the selection member (3) is rotatable around a rotation axis (x) with respect to the body (4) and with respect to the indication member (2), the non-masking section (46) and the masking section (45) partially overlap with the window (17) to define a displayed section (52) of the indication member (2), and wherein the selection member (3) and the indication member (2) are coupled such that the displayed section (52) of the indication member (2) is axially displaced within the window (17).

Abstract: A drive mechanism for a delivery device is presented. The drive mechanism comprises a housing (24) and a piston rod (6) having a longitudinal axis (x) and a piston rod feature (17). The drive mechanism further comprises a drive member (1) being movable with respect to the housing (24). The drive member (1) comprises a drive feature (15). The drive feature (15) is selectively engageable with the piston rod feature (17) by the radial displacement of the drive member (1) with respect to the piston rod (6). When the drive member (1) is in the first position, the drive member (1) is disengaged from the piston rod (6), and when the drive member (1) is in the second position, the drive feature (15) is engaged with the piston rod feature (17). When the drive member (1) moves distally with respect to the housing (24), said distal movement is transferred to the piston rod (6) such that the piston rod (6) moves distally with respect to the housing (24).

Abstract: The priming configuration comprises a piston rod (1), a bung (2), which is provided to be driven by the piston rod, and a movable element (5), which is engaged with the piston rod. The movable element is arranged to be movable in a predefined direction (10) with respect to the piston rod by a user of the drug delivery device. A movement of the movable element in the predefined direction advances the piston rod in a further direction (11), providing a priming of the drug delivery device before use. The predefined direction may especially be transverse to the further direction, and the further direction may especially be directed from the piston rod towards the bung (2). A gap (12) or clearance between the piston rod (1) and the bung (2) can thus be removed, and the stiction of the bung (2) to the cartridge (3) can be reduced.

Abstract: The invention refers to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing (10), a cartridge (170) containing a medicament and a last dose protection mechanism for preventing the selection of a dose, which exceeds the amount of medicament left in a cartridge (170). This last dose protection mechanism comprises a first member (60), which is rotatable in a first direction during dose FIG. 2 selecting and in the opposite direction during dose dispensing, a second member (50) coupled to the first member (60) and to the housing (10) such that the second member is moved relative to the first member (60) and to the housing (10) upon rotation of the first member (60) and a third member (100) which is moved relative to the first and second member (50, 60) during dose dispensing. Abutment of the second and third member (50, 100) prevents increasing the selected dose.

Abstract: An assembly for a drug delivery device (200) is presented which comprises a housing (24) having a proximal end (25) and a distal end (26), a cartridge, a plunger (19) which is movably retained in the cartridge (14) and a piston rod (6). The assembly further comprises a rod displacement feature (33). The assembly is configured such that, in an initial state of the assembly, the piston rod (6) and the rod displacement feature (33) are arranged such that movement of the rod displacement feature (33) from the first position to the second position is transferred to the piston rod (6) such that the piston rod (6) is moved with respect to the cartridge (14) and the assembly is switched from the initial state to a primed state. In the primed state, movement of the rod displacement feature (33) from the first position to the second position is not transferred to the piston rod (6).

Abstract: The invention relates to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament including a dose limiter for preventing the setting of a dose, which exceeds the amount of liquid left in a cartridge of the drug delivery device. The device comprises a housing (10, 20), a dose selector (140) for selecting a dose by rotation relative to the housing (10, 20), a dosing element (40, 130), and a releasable clutch (45, 143) for rotationally coupling the dosing element (40, 130) to the dose selector (140) during dose selecting and for rotationally decoupling the dosing element (40, 130) from the dose selector (140) during dose dispensing. The clutch comprises a male spline (45), a corresponding female spline (143) and a curved or inclined surface (142) which is orientated such that re-engagement of the clutch guides the male spline (45) into a predefined rotational orientation with respect to the female spline (143).

Abstract: A drive assembly for a drug delivery device (100) is presented. The drive assembly comprises a housing (4) having a proximal end (18) and a distal end (19) and a main drive mechanism comprising a drive member (5), a piston rod (7) and a resilient member (13). The main drive mechanism being configured such that, in a setting mode of operation, the resilient member (13) is biased when a dose of a drug (35) is set and in a dispensing mode of operation, the set dose is dispensed, wherein the drive member (5) drives the piston rod (7). The drive assembly further comprises an auxiliary drive mechanism further comprising an auxiliary drive member (26) which is coupled to the drive member (5). In the dispensing mode of operation, the auxiliary drive mechanism can be actuated by a user via a movement of the auxiliary drive member (26) with respect to the housing (4), thereby mechanically assisting the dispensing action of the main drive mechanism.

Abstract: The invention refers to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises at least one clicker mechanism (52, 64; 143, 153) for generating a haptic and/or audible feedback during dose selecting, wherein the clicker mechanism (143, 153) generates a different feed-back when selecting single units or multiples of single units.

Abstract: An indication assembly (100) is presented. The indication assembly (100) comprises indication members (110, 120) further comprising interaction features (111, 121). The indication assembly (100) comprises a locking member (130) which is movable with respect to the indication members (110, 120) between a locking position and a non-locking position. The locking member (130) comprises a locking member feature (131), wherein the indication members (110, 120) are rotatable relative to the locking member (130) around an axis (x). The indication assembly (100) is configured such that when the locking member (130) is in the non-locking position, the indication members (110, 120) are rotatable by a predetermined angle in a first rotational direction.

Abstract: The invention refers to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing (10), a cartridge holder (20) for receiving a cartridge (170), a lead screw (30) and means (40, 90) for driving the lead screw (30) during dose dispensing. The lead screw (30) is coupled to the cartridge holder (20) such that the cartridge holder (20) is axially displaced with respect to the housing (10) and the lead screw (30) during dose dispensing.

Abstract: A drive mechanism for a delivery device or a positioning mechanism comprising a rod (5), a rotatable cam member (9), and a follower member (6) being coupled to the cam member (9) in such a manner that a rotation of the cam member (9) is transferred to a reciprocating movement of the follower member (6) or a part thereof (7), the follower member (6) being coupled to the rod (5) via a ratchet mechanism (62, 64) in such a manner that the reciprocating movement of the follower member (6) or the part thereof (7) drives the rod (5).

Abstract: The invention relates to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament including a dose limiter for preventing the setting of a dose, which exceeds the amount of liquid left in a cartridge of the drug delivery device. The device comprises a cartridge (80) containing liquid, preferably a medicament, a dosing element (40, 130), which rotates during dose selecting, a last dose nut (110) coupled to the dosing element (40, 130) during dose selecting such that rotation of the dosing element (40, 130) causes an axial movement of the last dose nut (110), and a stop element (137), which is provided on the dosing element (40, 130) and which blocks further movement of the last dose nut (110), if a dose is selected corresponding to the amount of liquid left in the cartridge (80).

Abstract: Systems and methods are described for non-invasively acoustically monitoring containers to distinguish gas contents from liquid contents. In some embodiments the container is part of a buoyancy tank (132) in a subsea pipeline network (102) used to transport production fluid from a subsurface wellhead (112) to surface facilities, and the systems and methods are used to detect water ingression into the buoyancy tank (132) and to transmit alert signals to the surface relating thereto.

Abstract: A method of treating or preventing a pathological condition of the uterus in an female individual, the method comprising administering to the individual at least one agent that prevents PGF2?, having its effect on the FP receptor. Typically, the pathological condition is uterine cancer, fibroids or endometriosis.