Abstract: A system for filling an on-body injector includes the on-body injector having a medicament reservoir, a fill cartridge having an internal chamber containing a medicament, and a filling station for receiving the on-body injector and the fill cartridge. The filling station includes an injector socket for receiving the on-body injector, a cartridge socket for receiving the fill cartridge, a fluid path section providing fluid communication between the injector socket and the cartridge socket and a pump operatively engaging the fluid path section to transfer the medicament from the internal chamber of the fill cartridge to the medicament reservoir of the on-body injector.

Abstract: A drug delivery device configured to deliver a medicament to a patient includes a cannula for piercing the patient's skin, a pump for driving medicament to the cannula, and a reservoir bag fluidly connected to the pump. The reservoir bag includes a first membrane layer and a second membrane layer defining a medicament chamber. At least one of the first membrane layer and the second membrane layer comprises a tunnel extending at least partially into the medicament chamber.

Abstract: Provided herein is a wearable drug delivery device including a housing having a skin-facing surface defining a cannula opening, the skin-facing surface configured to releasably attach to a patient's skin, a microcontroller received within the housing and including at least one processor, a sensor in communication with the microcontroller, the sensor configured to detect the patient's skin, a container disposed within the housing and configured to store a pharmaceutical composition therein, and a cannula in fluid communication with the container, the cannula transitionable from an initial position in which the cannula is disposed within the housing to a use position in which the cannula extends through the cannula opening.

Abstract: A drug delivery device that includes a sensor to evaluate movement of the device relative to the body it is attached to and at least one processor in communication with the sensor, where the at least one processor is programmed or configured to receive data associated with the sensor from the sensor, determine a characteristic associated with the sensor based on the data received from the sensor, determine whether the characteristic associated with the sensor satisfies a threshold, and perform an action based on determining that the data received from the sensor satisfies the threshold.

Abstract: A drug delivery device that includes a sensor and at least one processor in communication with the sensor, where the at least one processor is programmed or configured to receive data associated with a fluid flow path from the sensor, determine a characteristic associated with the fluid flow path based on the data received from the sensor, determine whether the characteristic associated with the fluid flow path satisfies a threshold, and perform an action based on determining that the data associated with the fluid flow path satisfies the threshold. The sensor and processor analyzing data to determine successful deployment of cannula in target tissue and detect removal of cannula from target tissue.

Abstract: A drug delivery device includes a reservoir configured to receive a fluid, a cannula in fluid communication with the reservoir, with the cannula configured to be inserted into subcutaneous tissue or muscle tissue of a patient, and a pump configured to deliver a fluid from the reservoir to the cannula. The cannula includes a bioactive agent configured to cause a tissue response to decrease a pressure required to deliver fluid from the reservoir. The tissue response can include vasodilation, vasoconstriction, increased tissue permeability, increased flow of interstitial fluid or enzymatic deterioration of extracellular matrix.