Abstract: A drug delivery device that includes a sensor to evaluate movement of the device relative to the body it is attached to and at least one processor in communication with the sensor, where the at least one processor is programmed or configured to receive data associated with the sensor from the sensor, determine a characteristic associated with the sensor based on the data received from the sensor, determine whether the characteristic associated with the sensor satisfies a threshold, and perform an action based on determining that the data received from the sensor satisfies the threshold.

Abstract: A drug delivery device that includes a sensor and at least one processor in communication with the sensor, where the at least one processor is programmed or configured to receive data associated with a fluid flow path from the sensor, determine a characteristic associated with the fluid flow path based on the data received from the sensor, determine whether the characteristic associated with the fluid flow path satisfies a threshold, and perform an action based on determining that the data associated with the fluid flow path satisfies the threshold. The sensor and processor analyzing data to determine successful deployment of cannula in target tissue and detect removal of cannula from target tissue.

Abstract: A drug delivery device includes a reservoir configured to receive a fluid, a cannula in fluid communication with the reservoir, with the cannula configured to be inserted into subcutaneous tissue or muscle tissue of a patient, and a pump configured to deliver a fluid from the reservoir to the cannula. The cannula includes a bioactive agent configured to cause a tissue response to decrease a pressure required to deliver fluid from the reservoir. The tissue response can include vasodilation, vasoconstriction, increased tissue permeability, increased flow of interstitial fluid or enzymatic deterioration of extracellular matrix.