Patents by Inventor Stuart Ray

Stuart Ray has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Macrocyclic compound
    Patent number: 12577258
    Abstract: A compound represented by the general formula (1) or a salt thereof, which has a superior IRAK-4 inhibitory activity, and is useful as active ingredients of medicaments for prophylactic treatment and/or therapeutic treatment of diseases relating to IRAK-4 inhibition.
    Type: Grant
    Filed: September 30, 2020
    Date of Patent: March 17, 2026
    Assignees: VERNALIS (R&D) LIMITED, ASAHI KASEI PHARMA CORPORATION
    Inventors: Takahiko Ito, Misato Takashima, Masakazu Atobe, Koichiro Arai, Tomohisa Toyama, Yu Yoshii, Andrew John Potter, Daniel Paul Maddox, Stuart Ray, Nicolas Foloppe
  • ANTIBODY-DRUG CONJUGATES OF ANTINEOPLASTIC COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20250387504
    Abstract: Antibody-drug conjugates that bind to human oncology targets are disclosed. The antibody-drug conjugates comprise an antibody or an antigen-binding fragment thereof covalently linked to at least one BH3 mimetic through a dual linker. The disclosure further relates to methods and compositions for use in the treatment of cancers by administering the antibody-drug conjugates provided herein. Linker-drug conjugates comprising at least one BH3 mimetic and methods of making the same are also disclosed.
    Type: Application
    Filed: May 19, 2023
    Publication date: December 25, 2025
    Inventors: Matthew T. Burger, Zhuoliang Chen, Joseph Anthony D'Alessio, Gregory John Hollingworth, Claudia Judith Klinter, Jean-Baptiste Langlois, Eric Andrew McNeill, Cornelia Anne Mundt, Katsumasa Nakajima, Richard Vaughan Newcombe, Katharina Madörin, Bing Yu, Qiang Zhang, Imre Fejes, Olivier Geneste, Ana Leticia Maragno, Stuart Ray, Francesca Rocchetti, Jérôme-Benoit Starck, Zoltán Szlavik, Vesela Kostova, Tibor Novák
  • 5-[7-(3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBONYL)-1,2,3,4 TETRAHYDROISOQUINOLIN-6-YL]-1H-PYRROLE-3-CARBOXAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS PRO-APOPTOTIC AGENTS
    Publication number: 20250179047
    Abstract: A compound of formula (I): wherein R3, R4, R5, R6, Z1, Z2 and T are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring anti-apoptotic inhibitors.
    Type: Application
    Filed: February 23, 2023
    Publication date: June 5, 2025
    Inventors: Annamária BALASSA, Paul Andrew BROUGH, Audrey CLAPERON, Didier DEMARLES, Imre FEJES, Eszter FÖRDÖS, Balázs KOMJÁTI, Daniel MADDOX, Balázs MOLNÁR, James Brooke MURRAY, Stuart RAY, Francesca ROCCHETTI, Emma SANDERS, Melinda SIPOS, Zoltán SIPOS, Zoltán SZLÁVIK, Claire Louise WALMSLEY, Yikang WANG
  • SPIROCYCLOHEXANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS ANTI-APOPTOTIC INHIBITORS
    Publication number: 20240150293
    Abstract: Compounds of Formula (I): wherein R1, R3, R11, R12, X, Y1, Y2, Y3, Y4 and are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring anti-apoptotic inhibitors.
    Type: Application
    Filed: January 11, 2022
    Publication date: May 9, 2024
    Inventors: Stephen STOKES, Simon BEDFORD, l-Jen CHEN, James Edward Paul DAVIDSON, Nicholas DAVIES, Christopher John GRAHAM, Sean Martin MCKENNA, Johannes W.G. MEISSNER, James Brooke MURRAY, Rachel Jane PARSONS, Stuart RAY, Emma SANDERS, Claire Louise WALMSLEY, Paul Andrew BROUGH, András KOTSCHY, Ágnes PROSZENYÁK, Ádám SINAI, Balázs Károly BÁLINT, Márton CSÉKEI, Márton ZWILLINGER, Rita GARAMVÖLGYI, Szabolcs SIPOS, Vilibald KUN, Zoltán SZABÓ, Maïa CHANRION, Francesca ROCCHETTI, Frédéric COLLAND, Ana Leticia MARAGNO, Laura BRESSON
  • MACROCYCLIC COMPOUND
    Publication number: 20230357271
    Abstract: A compound represented by the general formula (1) or a salt thereof, which has a superior IRAK-4 inhibitory activity, and is useful as active ingredients of medicaments for prophylactic treatment and/or therapeutic treatment of diseases relating to IRAK-4 inhibition.
    Type: Application
    Filed: September 30, 2020
    Publication date: November 9, 2023
    Applicants: Asahi Kasei Pharma Corporation, Vernalis (R&D) Limited
    Inventors: Takahiko ITO, Misato TAKASHIMA, Masakazu ATOBE, Koichiro ARAI, Tomohisa TOYAMA, Yu YOSHII, Andrew John POTTER, Daniel Paul MADDOX, Stuart RAY, Nicolas FOLOPPE
  • Hepatitis C virus gene sequences and methods of use therefor
    Patent number: 11596679
    Abstract: The present disclosure relates to compositions and methods for inducing an adaptive immune response against Hepatitis C virus (HCV) in a subject. In some embodiments, the present disclosure provides a composition comprising a nucleic acid molecule encoding a HCV antigen, an HCV antigen, an adjuvant, or a combination thereof. For example, in some embodiments, the composition comprises a vaccine comprising a nucleic acid molecule encoding a HCV antigen, an HCV antigen, an adjuvant, or a combination thereof.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: March 7, 2023
    Assignees: VANDERBILT UNIVERSITY, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE JOHNS HOPKINS UNIVERSITY
    Inventors: James E. Crowe, Jr., Andrew Flyak, Justin Bailey, Stuart Ray, George Shaw
  • HEPATITIS C VIRUS GENE SEQUENCES AND METHODS OF USE THEREFOR
    Publication number: 20200188504
    Abstract: The present disclosure relates to compositions and methods for inducing an adaptive immune response against Hepatitis C virus (HCV) in a subject. In some embodiments, the present disclosure provides a composition comprising a nucleic acid molecule encoding a HCV antigen, an HCV antigen, an adjuvant, or a combination thereof. For example, in some embodiments, the composition comprises a vaccine comprising a nucleic acid molecule encoding a HCV antigen, an HCV antigen, an adjuvant, or a combination thereof.
    Type: Application
    Filed: April 27, 2018
    Publication date: June 18, 2020
    Applicants: Vanderbilt University, The Trustees of the University of Pennsylvania, The John Hopkins University
    Inventors: James E. CROWE, JR., Andrew FLYAK, Justin BAILEY, Stuart RAY, George SHAW
  • Indole and pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 10662173
    Abstract: Compounds of formula (I): wherein Ra, Rb, Rc, Rd, R3, R4, R5, A1, A2, T and W are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: May 26, 2020
    Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTD
    Inventors: Patrick Casara, Thierry Le Diguarher, Jean-Michel Henlin, Jérôme-Benoît Starck, Arnaud Le Tiran, Guillaume De Nanteuil, Olivier Geneste, James Edward Paul Davidson, James Brooke Murray, I-Jen Chen, Claire Walmsley, Christopher John Graham, Stuart Ray, Daniel Maddox, Simon Bedford
  • Blending device for blending a sample in a sealable bag
    Patent number: 10207234
    Abstract: A blending device (2) for blending a sample held in a sealable open mouthed sample bag comprises a bag receiving portion (6). The blending device (2) also includes a kneading arrangement (20) for acting on a wall of a sample bag (8) disposed in the bag receiving portion (6) so as to blend a sample contained in the bag (8). A bag manipulation arrangement (13) or a bag support (28) may also be provided.
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: February 19, 2019
    Assignee: Seward, LTD.
    Inventors: Stuart Ray, Geoffrey Matthews, John Patrick
  • PYRROLO[2,3-d]PYRIMIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20180273538
    Abstract: Compounds of formula (I): wherein R1, R2, W3, W4, A1, and A2 are as defined in the description. Medicinal products containing the same which are useful in treating cancer, neurodegenerative disorders and metabolic disorders.
    Type: Application
    Filed: September 30, 2016
    Publication date: September 27, 2018
    Inventors: Andrea FIUMANA, Nicolas FOLOPPE, Stuart RAY, David WALMSLEY, András KOTSCHY, Michael BURBRIDGE, Francisco Humberto CRUZALEGUI
  • INDOLE AND PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20170342051
    Abstract: Compounds of formula (I): wherein Ra, Rb, Rc, Rd, R3, R4, R5, A1, A2, T and W are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.
    Type: Application
    Filed: August 14, 2017
    Publication date: November 30, 2017
    Inventors: Patrick CASARA, Thierry Le Diguarher, Jean-Michel Henlin, Jérôme-Benoît Starck, Arnaud Le Tiran, Guillaume De Nanteuil, Olivier Geneste, James Edward Paul Davidson, James Brooke Murray, I-Jen Chen, Claire Walmsley, Christopher John Graham, Stuart Ray, Daniel Maddox, Simon Bedford
  • Indole and pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 9765056
    Abstract: Compounds of formula (I): wherein Ra, Rb, Rc, Rd, R3, R4, R5, A1, A2, T and W are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
    Type: Grant
    Filed: July 22, 2014
    Date of Patent: September 19, 2017
    Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTD
    Inventors: Patrick Casara, Thierry Le Diguarher, Jean-Michel Henlin, Jéröme-Benoit Starck, Arnaud Le Tiran, Guillaume De Nanteuil, Olivier Geneste, James Edward Paul Davidson, James Brooke Murray, I-Jen Chen, Claire Walmsley, Christopher John Graham, Stuart Ray, Daniel Maddox, Simon Bedford
  • DEVICES FOR BLENDING MATERIALS
    Publication number: 20170157577
    Abstract: A blending device (2) for blending a sample held in a sealable open mouthed sample bag comprises a bag receiving portion (6). The blending device (2) also includes a kneading arrangement (20) for acting on a wall of a sample bag (8) disposed in the bag receiving portion (6) so as to blend a sample contained in the bag (8). A bag manipulation arrangement (13) or a bag support (28) may also be provided.
    Type: Application
    Filed: February 21, 2017
    Publication date: June 8, 2017
    Applicant: Seward, LTD.
    Inventors: Stuart RAY, Geoffrey MATTHEWS, John PATRICK
  • INDOLE AND PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20160152599
    Abstract: Compounds of formula (I): wherein Ra, Rb, Rc, Rd, R3, R4, R5, A1, A2, T and W are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
    Type: Application
    Filed: July 22, 2014
    Publication date: June 2, 2016
    Applicants: Les Laboratoires Servier, Vernails (R&D) Limited
    Inventors: Patrick CASARA, Thierry LE DIGUARHER, Jean-Michel HENLIN, Jéröme-Benoit STARCK, Arnaud LE TIRAN, Guillaume DE NANTEUIL, Olivier GENESTE, James Edward Paul DAVIDSON, James Brooke MURRAY, I-Jen CHEN, Claire WALMSLEY, Christopher John GRAHAM, Stuart RAY, Daniel MADDOX, Simon BEDFORD
  • Blender
    Publication number: 20140092702
    Abstract: A blending device (2) for blending a sample held in a sealable open mouthed sample bag comprises a bag receiving portion (6). The blending device (2) also includes a kneading arrangement (20) for acting on a wall of a sample bag (8) disposed in the bag receiving portion (6) so as to blend a sample contained in the bag (8). A bag manipulation arrangement (13) or a bag support (28) may also be provided.
    Type: Application
    Filed: September 27, 2013
    Publication date: April 3, 2014
    Applicant: Seward Ltd
    Inventors: Stuart Ray, Geoffrey Matthews, John Patrick
  • Devices for blending materials and bags and for use in such devices
    Publication number: 20070140047
    Abstract: A device for blending materials and a bag for use in such devices. The device has at least one paddle for acting on a sample and a carrier against which a sample may be crushed by the paddle. The device is arranged to allow adjustment of the spacing between the paddle and carrier during operation. The bag is suitable for use in such a device but can be used in other devices.
    Type: Application
    Filed: March 7, 2005
    Publication date: June 21, 2007
    Applicant: SEWARD LIMITED
    Inventors: Stuart Ray, Graham Gibbins
  • Blender
    Patent number: D775364
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: December 27, 2016
    Assignee: SEWARD LIMITED
    Inventors: Stuart Ray, Geoffrey Matthews, John Patrick