Abstract: Systems and methods of indirectly illuminating a step surface of a vehicle running board are provided. A running board may include an upper step surface and at least one lighting element provided at an inboard underside of the running board to directly illuminate the undercarriage of the vehicle and a ground surface below the running board. The lighting element may be configured to direct light to a reflecting element provided at the undercarriage for reflecting light provided by the at least one lighting element to indirectly illuminate the upper step surface of the running board. Associated vehicles including the running board are provided. Associated methods are also provided.

Abstract: Systems, methods, and machine-executable coded instruction sets are disclosed for fully- and/or partly automated handling of goods. The disclosure provides improvements in the storage and retrieval of storage and delivery containers in order processing systems.

Abstract: Systems, methods, and machine-executable coded instruction sets are disclosed for fully- and/or partly automated handling of goods. The disclosure provides improvements in the storage and retrieval of storage and delivery containers in order processing systems.

Abstract: A handheld weaving tool is provided, the tool including a housing having a first end opposite a second end and a sidewall extending therebetween defining an interior volume. The second end comprises at least one aperture therethrough. A needle is disposed within the housing and can selectively move between an extended position and a retracted position, wherein an extended position, the needle extends through the aperture, and wherein a retracted position, the needle is disposed entirely within the housing. An opening is disposed in the first end, wherein the opening is dimensioned to receive a thread therethrough, such that the thread is operably connected to the needle. A motor is disposed within the housing and can reciprocally move the needle between the extended position and the retracted position. A control is disposed on the housing and activates the motor when actuated.

Abstract: Disclosed herein are devices, systems, and methods for measuring socket fit in lower limb prostheses and detecting motion of a residual limb relative to a prosthetic socket. Also disclosed herein are methods for developing a socket-fit detection system for sock management that can be applied to adjustable socket systems.

Abstract: Systems, methods, and machine-executable coded instruction sets are disclosed for fully- and/or partly automated handling of goods. The disclosure provides improvements in the storage and retrieval of storage and delivery containers in order processing systems.

Abstract: Disclosed herein are devices, systems, and methods for measuring socket fit in lower limb prostheses and detecting motion of a residual limb relative to a prosthetic socket. Also disclosed herein are methods for developing a socket-fit detection system for sock management that can be applied to adjustable socket systems.

Abstract: The present invention relates to chemical linkers and protecting groups, compounds and compositions containing the chemical linkers or protecting groups, and intermediates and processes that can be used to prepare them. The chemical linkers and protecting groups are based on pyrrolidine and piperidine activating groups, which undergo intramolecular cyclisation upon heating with release of carbon dioxide, thereby releasing the organic compound from a substrate. In particular, those chemical linkers and protecting groups are useful in the solid phase synthesis of oligonucleotides according to the following representative schemes.

Abstract: The present invention relates to chemical linkers and protecting groups, compounds and compositions containing the chemical linkers or protecting groups, and intermediates and processes that can be used to prepare them. The chemical linkers and protecting groups are based on pyrrolidine and piperidine activating groups, which undergo intramolecular cyclisation upon heating with release of carbon dioxide, thereby releasing the organic compound from a substrate. In particular, those chemical linkers and protecting groups are useful in the solid phase synthesis of oligonucleotides according to the following representative schemes.

Abstract: A handheld weaving tool is provided, the tool including a housing having a first end opposite a second end and a sidewall extending therebetween defining an interior volume. The second end comprises at least one aperture therethrough. A needle is disposed within the housing and can selectively move between an extended position and a retracted position, wherein an extended position, the needle extends through the aperture, and wherein a retracted position, the needle is disposed entirely within the housing. An opening is disposed in the first end, wherein the opening is dimensioned to receive a thread therethrough, such that the thread is operably connected to the needle. A motor is disposed within the housing and can reciprocally move the needle between the extended position and the retracted position. A control is disposed on the housing and activates the motor when actuated.

Abstract: Systems, methods, and machine-executable coded instruction sets are disclosed for fully- and/or partly automated handling of goods. The disclosure provides improvements in the storage and retrieval of storage and delivery containers in order processing systems.

Abstract: The present disclosure describes timer devices that include a timer to monitor a time period and a signalling apparatus that provides an alert signal on expiry of the time period. In some embodiments, a label assembly is provided including first and second labels releasably connected to each other, each label each including a timer and signalling apparatus, In some embodiments, a label is provided with first, second and third portions, the first and second portions including respective fixing portions and the third portion including a timer and signalling apparatus.

Abstract: A minimally invasive laparoscopic tissue removal device, namely a morcellator. The device includes, from proximal end to distal end, a handle, handle guard, elongate sheath, and mouth, finally terminating in a safety tip. The elongate sheath and mouth are concentric, such that two elongate, rotating cutting/shredding blades/teeth and one elongate auger feed screw can be positioned along the length of the sheath and mouth. The teeth are opposingly disposed and staggered, such that contact with tissue mass grabs and pulls tissue inwards toward the auger, which transports the tissue proximally toward the outside of the patient's body. A motor unit and gear assembly can be coupled to the teeth and auger to drive rotation of the teeth and auger. A cup assembly can be disposed in overlying relation to the mouth for guiding the tissue mass towards the mouth. Various mechanisms of safely covering the mouth are contemplated as well.

Abstract: A system and methodology for the automated localization, extraction, and analysis of MRI-based features with clinical information to improve the diagnosis of pelvic organ prolapse (POP). The system can automatically identify reference points for pelvic floor measurements on MRI rapidly and consistent. It provides a prediction model that analyzes the correlation between current and new MRI-based features with clinical information to differentiate patients with and without POP. This system will enable the high throughput analysis of MR images for their correlation with clinical information to better detect POP. The presented system can also be applied to the automated localization and extraction of MRI features for the diagnosis of other diseases where clinical examination is not adequate.

Abstract: Disclosed herein are devices, systems, and methods for measuring socket fit in lower limb prostheses and detecting motion of a residual limb relative to a prosthetic socket. Also disclosed herein are methods for developing a socket-fit detection system for sock management that can be applied to adjustable socket systems.

Abstract: Systems 1000, methods, and machine-executable coded instruction sets for the fully- and/or partly automated handling of goods. In particular, the disclosure provides improvements in the storage and retrieval of storage and delivery containers in order processing systems.

Abstract: A laparoscopic device with obturator. The device facilitates extraction of specimens from a female subject's abdominal cavity through the subject's vagina by also facilitating the suturing of a mesh to the anterior and posterior walls of the subject's vagina. The device includes an elongate sheath that has a flat surface on the front, a curved shape on the back, and an inner port opening formed within the flat surface, where the port opening that enables introduction of instruments or removal of specimens from the peritoneal cavity. An internal obturator can be inserted into the sheath to reduce the size of the port opening into the peritoneal cavity, or can be used to close the inner port opening into the peritoneal cavity. The obturator and sheath can be utilized as firm surfaces against which a user can suture a sacrocolpopexy mesh to the anterior and posteriors vaginal walls.

Abstract: A method of manufacturing a synthetic tissue model using one or more semi-flexible polymers or resin with at least one embedded mesh material is provided herein. The model provides suitable simulation of animal tissue designed to mimic tissue stiffness through varying the polymerization to simulate tissue stiffness level. Multiple polymers or multiple layers of polymer possessing different polymerization levels can be used to simulate tissues with different layers, such as skin. A mesh incorporated in the model provides durability, and can simulate layers of tissue through selection of the mesh material. A skin model using silicone-like material with a nylon tulle mesh was used to simulate skin for surgical procedures. The nylon tulle mesh increased resistance to tearing over time, due to insertion of surgical tools, thereby increasing usable life of the model and enhancing training as the model simulated skin for longer periods of time.

Abstract: A vaginal cuff surgical model and methods of manufacture and use thereof. The model includes a body (resembling a vaginal cuff) and appendages (resembling uterosacral ligaments) extending from the body. The model (body and appendages) is formed of silicone, rubber, a polymer, or other suitable material with one or more layers of mesh embedded within the polymeric material. The embedded mesh permits suture between the components of the model. The surgical model permits surgical practice of this important component of a total hysterectomy procedure via suturing across the model and to the appendages.

Abstract: A label includes a timer to monitor a predetermined time period relating to a medical device, such as an indwelling cannula, or other product. The label includes a signalling apparatus that provides an alert signal on expiry of the predetermined time period and a fixing portion to fix the label to a support surface such as medical records of a patient. The label can have a first portion and a second portion and the first portion can be separable from the second portion. The fixing portion can be provided in the second portion and all or part of the signalling apparatus provided in the first portion. Also disclosed is a monitoring system for a medical device, including a base station and a label receivable by the base station. The monitoring system monitors a predetermined time period based on receipt of the label by the base station.