Abstract: Apparatus and methods for reconstituting and/or removing lyophilized and/or vialed drugs for topical application includes a syringe having a removable plunger. A vial extraction adapter can interconnect the syringe and a vial, allowing a user to transfer a reconstituting solution from the syringe to the vial. After appropriate mixing, the user can then easily remove the reconstituted drug solution from the vial into the syringe. A cap can then be placed on that end of the syringe and the plunger of the syringe can be removed. An application adapter can be placed over the opening from which the plunger was removed. A cap of the application adapter can cover an applicator end that can be used to apply the liquid drug substance from the syringe. The cap of the application adapter can be replaced and any unused drug produced can be stored until needed again.