Patents by Inventor Stuart Sealfon

Stuart Sealfon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYSTEMS AND METHODS FOR DIAGNOSING A DISEASE OR A CONDITION
    Publication number: 20260253670
    Abstract: Systems and methods for diagnosing a disease, a condition, or a characteristic in a subject are provided. In one such method, a future severity of an infection or inflammatory disease in a subject afflicted with the infection or inflammatory disease is predicted by obtaining a plurality of methylation levels. Each respective methylation level in the plurality of methylation levels represents a corresponding methylation level at a CpG site at a corresponding genetic locus in a plurality of genetic loci in a biological sample obtained from the subject. The plurality of methylation levels are inputted into a model comprising a plurality of parameters, where the model applies the plurality of parameters to the plurality of methylation levels to generate as output from the model an indication as to future severity of an infection or inflammatory disease in the subject.
    Type: Application
    Filed: September 1, 2023
    Publication date: August 27, 2026
    Inventors: Stuart Sealfon, Xi Chen, Zijun Zhang, Olga G. Troyanskaya, Zidong Zhang, Weiguang Mao, Maria Chikina, Daniel Chawla, Steven Kleinstein
  • Use of intrinsic reporters of cell signaling for high content drug profiling and toxicity screening
    Patent number: 7723023
    Abstract: The present invention identifies essentially all of the members of a specific group of genes that are preferentially transcribed upon the initialization of a signal transduction pathway. The present invention also discloses methods for detecting and/or quantifying the transcription of these specific genes. The present invention further discloses methods of using this information to characterize the effect of potential drugs on a cell. Solid supports comprising nucleic acids that can hybridize with the transcripts from this specific group of genes are also described.
    Type: Grant
    Filed: August 14, 2002
    Date of Patent: May 25, 2010
    Assignee: Mount Sinai School of Medicine
    Inventors: Stuart Sealfon, Elisa Wurmbach, Tony Yuen
  • Use of intrinsic reporters of cell signaling for high content drug profiling and toxicity screening
    Publication number: 20030165916
    Abstract: The present invention identifies essentially all of the members of a specific group of genes that are preferentially transcribed upon the initialization of a signal transduction pathway. The present invention also discloses methods for detecting and/or quantifying the transcription of these specific genes. The present invention further discloses methods of using this information to characterize the effect of potential drugs on a cell. Solid supports comprising nucleic acids that can hybridize with the transcripts from this specific group of genes are also described.
    Type: Application
    Filed: August 14, 2002
    Publication date: September 4, 2003
    Inventors: Stuart Sealfon, Elisa Wurmbach, Tony Yuen