Patents by Inventor Stuart Spencer Licht

Stuart Spencer Licht has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LIPID NANOPARTICLES AND POLYNUCLEOTIDES ENCODING ORNITHINE TRANSCARBAMYLASE FOR THE TREATMENT OF ORNITHINE TRANSCARBAMYLASE DEFICIENCY
    Publication number: 20240189449
    Abstract: This disclosure relates to mRNA therapy for the treatment of ornithine transcarbamylase deficiency (OTCD). mRNAs for use in the invention, when administered in vivo, encode human ornithine transcarbamylase (OTC). mRNA therapies of the disclosure increase and/or restore deficient levels of OTC expression and/or activity in subjects. mRNA therapies of the disclosure further decrease levels of toxic ammonia associated with deficient OTC activity in subjects.
    Type: Application
    Filed: March 24, 2022
    Publication date: June 13, 2024
    Inventors: Kerry Benenato, Alicia Anne Bicknell, Mark Cornebise, Athanasios Dousis, Andrew Jacob Giessel, Edward Hennessy, Ruchi Jain, Caroline Köhrer, Stuart Spencer Licht, Kanchana Ravichandran, David Reid