Abstract: The present disclosure relates methods for treating skin disorders caused by an immune deficiency with topical formulations comprising ethyl (R)-4-((1-(2-cyanoacetyl)piperidin-3-yl)amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate (Compound I) or pharmaceutically acceptable derivative thereof. In particular, the topical formulations described herein may be used to treat atopic dermatitis, alopecia areata, or vitiligo.

Abstract: Systems and methods are provided for deterministically estimating whether the location of a computing device that is fixed or mobile is inside a building or not using location data. Particularly, the system may compare 3D geoposition uncertainty region of a location to a 3D volumetric structure shape of the location, and determining a confidence value based on the comparison associated with a likelihood that the location associated with the computing device is indoors or outdoors. Various states of the computing device are supported by the substance of the disclosure, including indoor and outdoor states.

Abstract: Systems and methods are provided for deterministically estimating whether the location of a computing device that is fixed or mobile is inside a fully enclosed building or not (e.g., fully or partially indoors/outdoors). Various environments are supported by the substance of the disclosure, including fully or partially indoor and outdoor environments.

Abstract: A door operating mechanism displaces a door between a closed position and a deck position relative to a structure including a frame with a side door jamb and a head door jamb. The door operating mechanism includes a motor, and an actuator connected to the motor and disposed within the side door jamb. A cable is connected at one end to the actuator and at an opposite end to the door via a pulley assembly. A wire harness system electrically connects the motor to a plug connector. A control panel is mounted adjacent the door and is coupled with the motor via the wire harness system.

Abstract: Compositions and methods that may be useful for the treatment of a viral infection as well as for treating infection induced cytokine release syndrome (CRS) or acute respiratory distress syndrome (ARDS) are described herein. For example, pharmaceutical compositions containing Compound I as disclosed herein may be used to treat infection by a coronavirus, such as SARS-CoV-2 (“COVID-19”).

Abstract: Examples described herein provide automatic location of access points by a computing device. Examples may include receiving, by the computing device from each AP in a subset of a plurality of APs, a Global Navigation Satellite System (GNSS) signal measurement, and based on each received GNSS signal measurement, constraining, by the computing device, the map of relative AP locations by at least one translational degree of freedom or one rotational degree of freedom. Examples may include resolving, by the computing device, locations of the plurality of APs in the map of relative AP locations.

Abstract: A portable NMR probe for the analysis of dispersions, the portable NMR probe comprising: a base part; a detachable probe assembly detachably mounted on the base part and electrically connected to the base part, the detachable probe assembly comprising: a housing; and a radio-frequency coil assembly received in the housing, the radio-frequency coil assembly comprising an RF coil support that has a channel for receiving an NMR sample, and an RF coil wound around the RF coil support for transmitting radio-frequency pulses to the NMR sample and for detecting magnetic resonance responses from the NMR sample; and a field magnet arranged to generate a magnetic field in the detachable probe assembly.

Abstract: Disclosed are peptide conjugates that are calcitonin gene-related peptide (CGRP) receptor antagonists comprising a CGRP peptide, wherein at least one amino acid of the peptide is covalently conjugated to a lipid-containing moiety. Also disclosed are pharmaceutical compositions and kits comprising such conjugates, methods of preparing such conjugates, and uses of such antagonists.

Abstract: Embodiments of the invention involve providing assistance data to a global position and navigation receiver, for example topographical data, such that the receiver can decide on a specific action depending on that data. The topographical data may include one or both of geographical data and architectural data. Geographical data may include information about natural formations, such as hills, valleys, forests, etc. Architectural data may include manmade formations, such as streets, buildings, bridges, etc. The receiver may then interpret and decide on a course of action for controlling the receiver base on the assistance data.

Abstract: A method of identifying recommended media content items for a user comprises accessing media content item tokens for respective media content items available to the user; accessing a user preference token relating to the user; comparing the user preference token with the media content item tokens; and identifying the recommended media content items based on said comparison.

Abstract: Methods of treating vitiligo using JAK/STAT modulating compounds are provided herein. The JAK/STAT modulating compounds may be selected from 5-((2-((4-fluoro-3-methoxy-5-methylphenyl)amino)-5-methylpyrimidin-4-yl)amino)benzo[d] oxazol-2(3H)-one, disodium (5-((2-((4-fluoro-3-methoxy-5-methylphenyl)amino)-5-methylpyrimidin-4-yl)amino)-2-oxobenzo[d]oxazol-3(2H)-yl)methyl phosphate, tofacitinib, ruxolitinib, baricitinib, lestaurtinib, decernotinib, TG101348, Janex 1, PF-956980, WHI-P154, ZM-39923, NSC114792, cerdulatinib, fedratinib, PF-06263276, CEP-33779, AZD-1480, SHR0302, oclacitinib, filgotinib, gandotinib, momelotinib, pacritinib, upadacitinib, peficitinib, PF-04965842, N-(3-acetamido-5-(quinaxalin-2-yl) phenyl) acrylamide, 1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one malonate (PF-06651600), [(1S)-2,2-Difluorocyclopropyl][3-[2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-3,8-diazabicyclo[3.2.

Abstract: Embodiments of the invention involve providing assistance data to a global position and navigation receiver, for example topographical data, such that the receiver can decide on a specific action depending on that data. The topographical data may include one or both of geographical data and architectural data. Geographical data may include information about natural formations, such as hills, valleys, forests, etc. Architectural data may include manmade formations, such as streets, buildings, bridges, etc. The receiver may then interpret and decide on a course of action for controlling the receiver base on the assistance data.

Abstract: A degradable composite comprising a degradable matrix, a first fiber type and a second fiber type, wherein the first fiber type has a different rate of degradation to that of the second fiber type.

Abstract: A fault-tolerant router includes first and second router matrix card. The first and second router matrix cards receive a common set of 4n parity encoded input digital audio data streams and respectively generates therefrom, first and second sets of M output digital audio streams. As the first and second sets of data streams propagate along the first and second router matrix cards, respectively, one or more health bits are set whenever an error or other type of fault condition is detected. First and second parity check circuits are configured to detect parity errors and/or assess the relative health of the first and second sets of data streams and one of the two sets of data streams is selected as the output of the fault-tolerant router based upon either the parity error analysis, health analysis or both.

Abstract: A degradable composite comprising a degradable matrix, a first fibre type and a second fibre type, wherein the first fibre type has a different rate of degradation to that of the second fibre type.

Abstract: A system and method for enforcing a usage control for a document, including: receiving an encrypted message, the encrypted message including a first key and a usage information authorization for the document, the encrypted message responsive to a second key to extract the first key and the usage information authorization; accepting an encrypted device datastream and securely decrypting the encrypted device datastream using the first key by a device, the device manager: generating a decrypted device datastream derived from the encrypted device datastream, transmitting the decrypted device datastream to the device without writing the decrypted device datastream to a user-accessible memory; and using the second key to access a datastore and to update a usage record for the document with the usage information authorization and a device status signal, the serializer providing the device manager with the print authorization signal when a device request is consistent with the usage record.

Abstract: A print job is preferably displayed using a visual job ticketing application. An operator is enabled to create multiple job tickets describing print parameters to be applied to the print job. Using the visual job ticketing application, the operator may select a previously created job ticket to be used to display and/or print the print job. Alterations made to the print job are automatically propagated across all associated print job tickets. When creating new print job tickets, the operator may choose to start with a blank job ticket, a default job ticket, the last active job ticket or any previously created job ticket.

Abstract: Transmissions in which the mechanical gear shift arrangements are replaced by electro-hydraulic operated shift mechanisms that have to be able to be neutralised positively to ensure a proper operation. An arrangement and method are provided to determine the position of the shift rail so a shift can be made only if the conditions are right. To prevent engagement of two shift members at the same time and consequent damage in case of electronic failure, mechanical safety features such as detents are included.

Abstract: A shift control method for an automated manual transmission is provided. The method includes the step of modulating the force applied to a shift collar, via a shift rod and/or shift fork for example, during the engagement of the shift collar and a selected gear. The method modulates the initial engagement force applied to the shift collar when the rotational speed differential between the collar and gear is being adjusted, before increasing the force again following modulation. This modulation of the force decelerates the shift collar during the rotational speed adjustment and does not accelerate the shift collar to complete the engagement until after the modulation. In this way, a less abrupt engagement of the gear may be achieved. The control method may improve the driving characteristics of the vehicle employing the transmission and may also improve the power transmission efficiency.