Abstract: Provided is an engineered CRISPR/Cas12f1 (Cas14a1) system. Provided are an engineered guide RNA for more effectively performing cleavage, editing, or modifying of a target nucleic acid, and an engineered CRISPR/Cas12f1 (Cas14a1) system containing the engineered guide RNA. In addition, provided is a method of performing cleavage, editing, or modifying of a target nucleic acid by using the engineered guide RNA and the engineered CRISPR/Cas12f1 (Cas14a1) system including the engineered guide RNA.

Abstract: A method for providing a stereoscopic image of a display device includes receiving, by a display panel that includes first to N-th sub-pixels, wherein N is a positive integer that is greater than or equal to 2, first to M-th view input data that correspond to first to M-th view images, wherein M is a positive integer that satisfies M>N, allocating the first to M-th view input data to the first to N-th sub-pixels as corresponding first to N-th view image data in a first mode, and displaying, by plurality of lenses disposed on the display panel, a light field image in the first to N-th sub-pixels according to the first to N-th view image data.

Abstract: Provided are a method and apparatus for providing image playing rate information. The method including receiving, from a user terminal, a target image request signal, transmitting, to the user terminal, a target image in a first state or the target image in a second state, based on whether the target image request signal satisfies a specified standard, obtaining, from the user terminal, state information and image playing information of the target image for each specified time, and providing user-wise playing rate information of the target image, based on the state information and image playing information of the target image may be provided.

Abstract: A light emitting diode device includes a thin film transistor substrate having a plurality of light emitting areas, a first diode electrode and a second diode electrode on the thin film transistor substrate, a first passivation pattern between the first diode electrode and the second diode electrode, a plurality of micro light emitting diodes on the first passivation pattern, a first bridge pattern on the micro light emitting diodes and electrically connecting the first diode electrode to the micro light emitting diodes, and a second bridge pattern on the first bridge pattern and electrically connecting the second diode electrode to the micro light emitting diodes, wherein each sidewall of each of the micro light emitting diodes and each sidewall of the first passivation pattern form a same plane.

Abstract: A display device includes a display unit including a pixel which displays an image based on a first power voltage and a data signal, a gamma voltage generator which generates gamma voltages, and a data driver which generates the signal using the gamma voltages and provides the data signal to the pixel. The gamma voltage generator generates first and second reference voltages, generates first and second corrected reference voltages by correcting the first and second reference voltages using a target voltage and an external power voltage provided from the display unit in correspondence with the first power voltage, and generates the gamma voltages by dividing the first and second corrected reference voltages. The gamma voltage generator sets the target voltage based on at least one selected from the first reference voltage, the second reference voltage, and a ground voltage.

Abstract: The current disclosure relates to a composition for promoting bone regeneration, preventing or treating bone diseases using a composition containing a hydrogel and a stem cell spheroid and a use thereof, and a method for preparing the same, wherein the composition for bone regeneration has the effect of promoting bone regeneration of injured bone tissue and alleviating pain while promoting the differentiation of the injected mesenchymal stem cells into osteoblasts and osteocytes at the same time, and thus, can be used for the prevention or treatment of bone diseases.

Abstract: The present invention provides a method for manufacturing a high-nickel positive electrode active material comprising the steps of preparing a raw material containing nickel and cobalt; separating a liquid intermediate by leaching a metal component in the pulverized raw material using an acid and removing impurities; and co-precipitating a precursor of a positive electrode active material by adding a chelating agent and a hydroxide precipitant to the liquid intermediate.

Abstract: The present invention relates to a use for, by using the protein arginine methyltransferase 1 (PRMT1) protein or a gene encoding the same, preventing or treating a neuromuscular disease induced by motor neurons, particularly, damage to motor neurons caused by oxidative stress in the neuromuscular junction; and a method for screening a candidate material for activating the expression of PRMT1. PRMT1 deficiency in the motor nerve or neuromuscular junction induces aggravated degenerative motor nerve damage caused by aging, and DNA damage caused by oxidative stress and inflammation, thereby enabling the induction of neuromuscular disease, and thus the disease may be treated through the overexpression and activity of the PRMT1 protein and a gene encoding the same.

Abstract: A transgenic plant having cold resistance overexpressing thioredoxin Trx-h2 protein. More specifically, the present invention relates to a transgenic plant having cold resistance overexpressing thioredoxin Trx-h2 protein which is an interacting partner of cold-responsive C-repeat-binding transcription factors (CBF 1).

Abstract: The present technology provides triazolopyridin-3-ones or pharmaceutically acceptable salts thereof, preparation processes thereof, pharmaceutical compositions comprising the same, and uses thereof. The triazolopyridin-3-ones or their pharmaceutically acceptable salts exhibit inhibitory activity on VAP-1 and therefore can be usefully applied, e.g., for the treatment and prophylaxis of nonalcoholic hepatosteatosis (NASH).

Abstract: Disclosed are a novel coronavirus-derived receptor-binding domain variant having reduced ACE2-binding affinity, a fusion protein comprising the same, and the use thereof. It is possible to overcome the drawbacks of conventional vaccines using the coronavirus spike protein or receptor-binding domain thereof, wherein the reduced ACE2 expression due to binding to ACE2 and negative feedback may lead to side effects of the lungs or heart, and in particular, may be fatal to patients suffering from underlying diseases of the lungs or heart. In particular, the fusion protein constructed by fusing the coronavirus receptor-binding domain with the Fc domain is imparted with a greatly improved in-vivo half-life, and has superior efficacy by further combining N protein, M protein, ORF protein, or the like of SARS-CoV-2 therewith through additional modification and thus is highly applicable to a multivalent immunogenic composition.

Abstract: The present disclosure relates to a method and an apparatus for asynchronously allocating resources in a mobile edge computing (MEC) system. A method for asynchronously allocating resources in a base station of an MEC system, according to one embodiment of the present disclosure, may comprise the steps of: determining the optimal value of a predetermined variable for energy consumption minimization of the MEC system for a predetermined time period by using basic information about each of the base station, a server, and one or more terminals; transmitting configuration information about the optimal value to each of the server and the one or more terminals; and allocating a resource to each of the base station, the server, and the one or more terminals on the basis of the optimal value.

Abstract: An optical device including: a display device configured to display an image; and a lens including a plurality of reflectors that reflect the image from the display device to a first surface of the lens, wherein the plurality of reflectors include: a first reflector; and a second reflector having a size different from a size of the first reflector.

Abstract: The present technology provides triazolone derivatives or pharmaceutically acceptable salts thereof, preparation processes thereof, pharmaceutical compositions comprising the same, and the use thereof. The triazolone derivatives or their pharmaceutically acceptable salts exhibit selective inhibitory activity on VAP-1 and therefore can be usefully applied, e.g. for the treatment and prophylaxis of nonalcoholic hepatosteatosis (NASH).

Abstract: There is provided a technology for minimizing shape deformation of a block formed on a tire in a case of braking, driving, or the like of the tire. There is provided a tire with an interlocking band type 3D kerf according to the embodiment of the invention, including a kerf having a road holding part which is a space formed in the block by extending in a direction inward to the tire from a ground contact surface of the block that comes into contact with a road, a projection part which is a space in the block with both side wall surfaces that is formed by extending from the road holding part and at which a protrusion portion having a shape projecting from one side wall surface is formed, and a base part which is a space in the block that is formed by extending from the projection part.

Abstract: One aspect relates to a pharmaceutical composition for the prevention or treatment of cancer or an anticancer immune vaccine composition, including a polypeptide consisting of the amino acid sequence of SEQ ID NO: 1. The composition can enhance anticancer immunity by activating dendritic cells and T cells, and furthermore, can exhibit a remarkably excellent synergistic anticancer immune effect through administration in combination with an immune checkpoint inhibitor.

Abstract: A display device includes a display unit including a pixel which displays an image based on a first power voltage and a data signal, a gamma voltage generator which generates gamma voltages, and a data driver which generates the signal using the gamma voltages and provides the data signal to the pixel. The gamma voltage generator generates first and second reference voltages, generates first and second corrected reference voltages by correcting the first and second reference voltages using a target voltage and an external power voltage provided from the display unit in correspondence with the first power voltage, and generates the gamma voltages by dividing the first and second corrected reference voltages. The gamma voltage generator sets the target voltage based on at least one selected from the first reference voltage, the second reference voltage, and a ground voltage.

Abstract: A display device includes a display panel, and a lens array disposed on a surface of the display panel. The lens array includes a plurality of lenses and a light transmission characteristic control layer disposed on a valley of each of the lenses. The light transmission characteristic control layer includes a light absorbing material. A stacked thickness of the light transmission characteristic control layer is smaller than a height of each of the lenses.

Abstract: A porous carbon structure, a method for preparing the same, and a battery comprising the same are provided. The porous carbon structure has a core-shell structure including a core and a shell, the core comprising a first metal organic framework (MOF), and the shell comprising a second MOF, and the first MOF and the second MOF have different component elements and pore structure from each other. The porous carbon structure, when applied as a sulfur carrier, prevents leaching of polysulfide generated at a positive electrode into an electrolyte solution, and thereby improving performance and lifetime characteristics of a battery using sulfur as a positive electrode active material.

Abstract: A display device includes a thin film transistor on a base substrate and a signal wiring electrically connected to the thin film transistor. The signal wiring includes a main conductive layer including copper, and a capping layer including titanium the capping layer overlapping a portion of an upper surface of the main conductive layer. The signal wiring has a taper angle in a range of about 70° to about 90°. A thickness of the capping layer is in a range of about 100 ? to about 300 ?, and a thickness of the main conductive layer is in a range of about 1,000 ? to about 20,000 ?.