Abstract: The present disclosure provides a bioelectromagnetic circuit device, used for emitting a bioelectromagnetic wave having a particular frequency, so as to improve biological blood circulation, including: an electromagnetic circuit module, for generating a bioelectromagnetic wave having a particular frequency of 800 MHz to 1 GHz; an electric energy storage module, electrically connected to the electromagnetic circuit module, and used for storing electric energy and providing the electric energy to drive the electromagnetic circuit module; an antenna, electrically connected to the electromagnetic circuit module, and used for emitting the bioelectromagnetic wave externally; and an insulator, used for fixing the antenna, the electric energy storage module and the electromagnetic circuit module.

Abstract: A visible light communication system for vehicles, comprising a signal radiating device comprising a control unit, used for outputting a data signal; a coding unit, connected with the control unit for receiving the data signal, and coding the data signal into a transmission signal; a light emitting unit, connected with the coding unit and having at least one light emitting device for receiving the transmission signal and carrying the transmission signal onto a switch type light-source signal emitted from the at least one light emitting device; and a signal receiving device comprising a light receiving unit, used for receiving the switch type light-source signal carried with the transmission signal, and outputting the transmission signal; a decoding unit, connected with the light receiving unit, for receiving the transmission signal, and decoding the transmission signal into the data signal; and an application unit, used for receiving and identifying the data signal.

Abstract: The present invention provides a novel method of using an herbal chip for screening for candidate compounds as a GPCR agonist or antagonist from herbs by using a labeled anti-GPCR-GPCR as a probe for hybridization.

Abstract: The present invention provides a method for treating arthritic disorders, skin inflammatory disorders and pain, comprising administering to a subject an extract of Andrographis paniculata Nees, and also provides a herbal composition used therefor that comprises the extract of Andrographis paniculata Nees.

Abstract: The use of flavone derivatives of formula (I) in which R1, R2, R3, R4 and R5 independently represent hydrogen, hydroxy or an ester group; R6 represents hydrogen, hydroxy, an ester group or an O-glycoside group such as O-rhamnose, O-glucoside, O-retinoside or O-xyloside; and represents a single bond or a double bond; or the pharmaceutically acceptable salts thereof as TNF? antagonists or inhibitors.

Abstract: The present invention relates to andrographolide and its derivatives of the general formula (I), as well as the stereoisomers and salts of andrographolide and the derivatives. Andrographolide and its derivatives represented by general formula (I) defined above are useful as TNF? (tumor necrosis factor alpha) antagonists or inhibitors which have inhibitory effect on the binding of TNF? to TNF-RI. Andrographolide exhibited inhibitor activity with IC50 values 60 ?M on L929 cell proliferation/cytotoxicity assay without cell cytotoxicity. In addition, in the animal model test of collagen-induced arthritis, andrographolide exhibited 50% paw edema. Andrographolide and its derivatives are promising sources with high TNF?-inhibiting or antagonizing activity.

Abstract: A compound of formula 1-[3,4-dihydroxy-5-(2-hydroxyethyl)tetrahydrofuran-2-yl]pryimidine-2,4(1H,3H)-dione has inhibitory effects of matrix metalloproteinase-2 (gelatinase A) enzyme and binding of TNF? to TNF?-RI.

Abstract: The present invention discloses a chemically surface-treated plastic slide that is useful for the immobilization of proteins, peptides or small molecules to its surface for the fabrication of biochips. Also disclosed in the present invention is a surface-treated plastic slide made of polystyrene, which is useful for the immobilization of oligonucleotides or polynucleotides to its treated surface for the fabrication of DNA chips.

Abstract: The present invention discloses a method for ascertaining the quality of herbs by applying the techniques of biochip for detecting the presence of biologically active, desired ingredient(s) in the herbs.

Abstract: The present invention relates to a novel method useful for fast separation and quick identification of active ingredients in herbs. The separation procedures are efficient without tedious and time-consuming works by using chromatographies or HPLC. The present invention further relates to a method for ascertaining the quality of herbs by applying treated plastic slides on quality control of herbal fractions, based on identification of their biological activities.

Abstract: The present invention relates to a plastic slide which after being chemically surface-treated is useful for the immobilization of proteins, peptides or small molecules to its treated surface and thus is useful in the fabrication of biochips. The plastic slide has at least one cavity chamber, wherein the depth of the cavity chambers may be the same or different and generally ranges from less than about 0.1 mm to up to about 0.5 mm. The present invention also relates to a plastic slide made of polystyrene, which after being surface-treated is useful for the immobilization of oligonucleotides or polynucleotides to its treated surface and thus is useful in the fabrication of DNA chips.

Abstract: The invention discloses methods of treatment and prevention for TNF&agr;-related disorders and MMP-related disorders and compounds useful in such treatments. In particular, the invention dislcoses pharmaceutical compositions comprising a compound of the general formula: wherein X is a Zn(II) chelating group and selected from the group consisting of (CH2)nOH, (CH2)nNH2, (CH2)nSH, (CH2)mCOOH, (CH2)mCOOR, (CH2)mCONH2, (CH2)m″CONH—OH, (CH2)m″CONH—R, and (CH2)n′O(PO3)m″(m″+1), wherein n=2, 3, 4, or 5, n′=2 or 3, m=1, 2, 3, or 4, m′=1, 2, 3, 4, 5, or 6, m″=1, 2, 3, and R=—Cm′, H2m′+1 or aryl groups, especially 1-[3,4-dihydroxy-5-(2-hydroxyethyl)-tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione, which has an inhibitory effect on matrix metalloproteinase-2 (gelatinase A) and on the binding of TNF&agr; to TNF&agr;-RI.

Abstract: The present invention relates to a novel method useful for fast separation and quick identification of active ingredients in herbs. The separation procedures are efficient without tedious and time-consuming works by using chromatographies or HPLC. The present invention further relates to a method for ascertaining the quality of herbs by applying treated plastic slides on quality control of herbal fractions, based on identification of their biological activities.

Abstract: The present invention relates to a herbal chip comprising a plastic slide, a coating as a spacer on the plastic slide, and fractions or components obtained from herbs that are independently allocated in microarrays on the coating. The herbal chip is useful for screening for active ingredients contained in the herbs that have specific pharmacological or therapeutical functions.

Abstract: The invention discloses a compound of the general formula (I) 1

Abstract: The present invention discloses a method for ascertaining the quality of herbs by applying the techniques of biochip for detecting the presence of biologically active, desired ingredient(s) in the herbs.

Abstract: A compound of formula 1-[3,4-dihydroxy-5-(2-hydroxyethyl) tetrahydrofuran-2-yl]pryimidine-2,4(1H,3H)-dione has inhibitory effects of matrix metalloproteinase-2 (gelatinase A) enzyme and binding of TNF&agr; to TNF&agr;-RI.

Abstract: The present invention discloses a chemically surface-treated plastic slide that is useful for the immobilization of proteins, peptides or small molecules to its surface for the fabrication of biochips. Also disclosed in the present invention is a surface-treated plastic slide made of polystyrene, which is useful for the immobilization of oligonucleotides or polynucleotides to its treated surface for the fabrication of DNA chips.

Abstract: The present invention relates to a herbal chip comprising a plastic slide, a coating as a spacer on the plastic slide, and fractions or components obtained from herbs that are independently allocated in microarrays on the coating. The herbal chip is useful for screening for active ingredients contained in the herbs that have specific pharmacological or therapeutical functions.

Abstract: The present invention discloses a specific binding of adenosine to a platelet membrane receptor protein gpIIb/IIIa, and relates to the novel use of adenosine for inhibiting platelet aggregation and thrombosis. The present invention discloses that adenosine is useful as an antithrombotic.