Abstract: Novel peptides that bind to human PAC1 are provided. These peptides that are antagonists of PAC1 are useful in a number of PAC1 related disorders, including the treatment and/or prevention of headache disorders, including migraine, such as acute migraine.

Abstract: The present invention relates to antagonist antibodies of the human calcitonin gene-related peptide (CGRP) receptor as well as bispecific antigen binding proteins derived from the anti-CGRP antibodies that bind to and inhibit both the human CGRP receptor and another target, such as the human pituitary adenylate cyclase activating polypeptide type I receptor (PAC1) receptor. Pharmaceutical compositions comprising the anti-CGRP receptor antibodies and bispecific antigen binding proteins as well as methods for producing them are also disclosed. Methods of using the anti-CGRP receptor antibodies and bispecific antigen binding proteins to ameliorate, treat, or prevent conditions associated with the CGRP and PAC1 receptors, such as chronic pain, migraine, and cluster headache, are also described.

Abstract: The present invention relates to neutralizing antibodies of the human pituitary adenylate cyclase activating polypeptide type I receptor (PAC1) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the neutralizing antibodies are also described.

Abstract: Novel peptides that bind to human PAC1 are provided. These peptides that are antagonists of PAC1 are useful in a number of PAC1 related disorders, including the treatment and/or prevention of headache disorders, including migraine, such as acute migraine.

Abstract: The present invention relates to neutralizing antibodies of the human pituitary adenylate cyclase activating polypeptide type I receptor (PAC1) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the neutralizing antibodies are also described.

Abstract: The present invention relates to neutralizing antibodies of the human pituitary adenylate cyclase activating polypeptide type I receptor (PAC1) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the neutralizing antibodies are also described.

Abstract: A method and system for storing and retrieving extensible multi-dimensional display property configurations. In one embodiment, a method is disclosed for the display of content that is configurable to a variety of contextual environments by reading a plurality of settings that are associated with an electronic device requesting content. The plurality of settings defines the contextual environment of the electronic device. The method continues by incorporating the plurality of settings as values in the list of filter criteria. The list of filter criteria is organized in a hierarchical order and specifies the format within which to present the content to be displayed at the electronic device. Thereafter, the method continues by matching the list of filter criteria with a resource to be displayed with the content. The resource is retrieved from memory for ultimate delivery to the electronic device for display.

Abstract: A method and system for storing and retrieving extensible multi-dimensional display property configurations. In one embodiment, a method is disclosed for the display of content that is configurable to a variety of contextual environments by reading a plurality of settings that are associated with an electronic device requesting content. The plurality of settings defines the contextual environment of the electronic device. The method continues by incorporating the plurality of settings as values in the list of filter criteria. The list of filter criteria is organized in a hierarchical order and specifies the format within which to present the content to be displayed at the electronic device. Thereafter, the method continues by matching the list of filter criteria with a resource to be displayed with the content. The resource is retrieved from memory for ultimate delivery to the electronic device for display.