Patents by Inventor Su-Chun Zhang

Su-Chun Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210222123
    Abstract: Methods and compositions for expanding dopaminergic neuron progenitor cells are described herein that include use of compositions and culture media that have at least the following components: an FGF, an agonist of SHH signaling, an agonist of canonical Wnt signaling, and Wnt-C59. The methods include contacting dopaminergic neuron progenitor cells with a culture medium comprising an FGF, an agonist of SHH signaling, an agonist of canonical Wnt signaling, and Wnt-C59, to generate an expanded dopaminergic neuron progenitor cell population.
    Type: Application
    Filed: December 9, 2020
    Publication date: July 22, 2021
    Inventors: Su-Chun Zhang, Xiang Li
  • Patent number: 11002745
    Abstract: Methods and compositions relating to motor neurons derived from induced pluripotent stem cells of subjects having a neurodegenerative disease, where the motor neurons exhibit phenotypes characteristic of the neurodegenerative disease, are provided herein. In particular, the present invention provides methods for screening putative therapeutic agents and methods for diagnosing living subjects as having a neurodegenerative disease. In addition, the present invention provides therapeutic gene transfer methods for treating or preventing a neurodegenerative disease in a subject in need thereof.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: May 11, 2021
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Hong Chen
  • Publication number: 20200362301
    Abstract: Provided herein are efficient, scalable methods for in vitro production of human retinal progenitor cells. In addition, provided herein are methods for isolating pure populations of in vitro produced human retinal progenitor cells as well as kits and compositions comprising such pure populations of human retinal progenitor cells.
    Type: Application
    Filed: May 18, 2020
    Publication date: November 19, 2020
    Inventors: Su-Chun Zhang, Yunlong Tao
  • Publication number: 20200087620
    Abstract: Methods for expanding proliferating populations of neuronal subtype-specific progenitors and creating substantially pure populations of motor neurons are provided herein. In particular, the present invention provides methods for maintaining the unique gene profile and differentiation potential of neuronal subtype-specific progenitors, such as motor neuron progenitors and hindbrain serotonergic neural progenitors.
    Type: Application
    Filed: November 19, 2019
    Publication date: March 19, 2020
    Inventors: Su-Chun Zhang, Zhongwei Du
  • Patent number: 10487311
    Abstract: Methods for expanding proliferating populations of neuronal subtype-specific progenitors and creating substantially pure populations of motor neurons are provided herein. In particular, the present invention provides methods for maintaining the unique gene profile and differentiation potential of neuronal subtype-specific progenitors, such as motor neuron progenitors and hindbrain serotonergic neural progenitors.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: November 26, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Zhongwei Du
  • Patent number: 10160950
    Abstract: Methods for expanding proliferating populations of neuronal subtype-specific progenitors and creating substantially pure populations of motor neurons are provided herein. In particular, the present invention provides methods for maintaining the unique gene profile and differentiation potential of neuronal subtype-specific progenitors, such as motor neuron progenitors and hindbrain serotonergic neural progenitors.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: December 25, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Zhongwei Du
  • Publication number: 20180292418
    Abstract: Methods and compositions relating to motor neurons derived from induced pluripotent stem cells of subjects having a neurodegenerative disease, where the motor neurons exhibit phenotypes characteristic of the neurodegenerative disease, are provided herein. In particular, the present invention provides methods for screening putative therapeutic agents and methods for diagnosing living subjects as having a neurodegenerative disease. In addition, the present invention provides therapeutic gene transfer methods for treating or preventing a neurodegenerative disease in a subject in need thereof.
    Type: Application
    Filed: June 19, 2018
    Publication date: October 11, 2018
    Inventors: Su-Chun Zhang, Hong Chen
  • Patent number: 10024870
    Abstract: Methods and compositions relating to motor neurons derived from induced pluripotent stem cells of subjects having a neurodegenerative disease, where the motor neurons exhibit phenotypes characteristic of the neurodegenerative disease, are provided herein. In particular, the present invention provides methods for screening putative therapeutic agents and methods for diagnosing living subjects as having a neurodegenerative disease. In addition, the present invention provides therapeutic gene transfer methods for treating or preventing a neurodegenerative disease in a subject in need thereof.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: July 17, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Hong Chen
  • Publication number: 20180119098
    Abstract: Methods for expanding proliferating populations of neuronal subtype-specific progenitors and creating substantially pure populations of motor neurons are provided herein. In particular, the present invention provides methods for maintaining the unique gene profile and differentiation potential of neuronal subtype-specific progenitors, such as motor neuron progenitors and hindbrain serotonergic neural progenitors.
    Type: Application
    Filed: October 5, 2017
    Publication date: May 3, 2018
    Inventors: Su-Chun Zhang, Zhongwei Du
  • Publication number: 20160152950
    Abstract: Methods for expanding proliferating populations of neuronal subtype-specific progenitors and creating substantially pure populations of motor neurons are provided herein. In particular, the present invention provides methods for maintaining the unique gene profile and differentiation potential of neuronal subtype-specific progenitors, such as motor neuron progenitors and hindbrain serotonergic neural progenitors.
    Type: Application
    Filed: February 5, 2016
    Publication date: June 2, 2016
    Inventors: Su-Chun Zhang, Zhongwei Du
  • Publication number: 20150285822
    Abstract: Methods and compositions relating to motor neurons derived from induced pluripotent stem cells of subjects having a neurodegenerative disease, where the motor neurons exhibit phenotypes characteristic of the neurodegenerative disease, are provided herein. In particular, the present invention provides methods for screening putative therapeutic agents and methods for diagnosing living subjects as having a neurodegenerative disease. In addition, the present invention provides therapeutic gene transfer methods for treating or preventing a neurodegenerative disease in a subject in need thereof.
    Type: Application
    Filed: April 1, 2015
    Publication date: October 8, 2015
    Inventors: Su-Chun Zhang, Hong Chen
  • Patent number: 9080151
    Abstract: A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of FGF2, FGF4, FGF8, FGF 9, or RA wherein the cells are characterized by an neural tube-like rosette morphology and are Pax6+/Sox1+.
    Type: Grant
    Filed: May 6, 2011
    Date of Patent: July 14, 2015
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Xue-jun Li
  • Patent number: 8895302
    Abstract: Methods of efficiently converting primate pluripotent stem cells to GABA neurons or cholinergic neurons, as well as applications thereof, are disclosed.
    Type: Grant
    Filed: August 10, 2011
    Date of Patent: November 25, 2014
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Yan Liu, Lixiang Ma
  • Patent number: 8895301
    Abstract: A transcription factor both necessary and sufficient for human neuroectoderm specification, Pax6, as well as applications thereof, is disclosed.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: November 25, 2014
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Xiaoqing Zhang
  • Publication number: 20140248696
    Abstract: Methods for expanding proliferating populations of neuronal subtype-specific progenitors are provided herein. In particular, the present invention provides methods for maintaining the unique gene profile and differentiation potential of neuronal subtype-specific progenitors, such as motor neuron progenitors and hindbrain serotonergic neural progenitors.
    Type: Application
    Filed: February 28, 2014
    Publication date: September 4, 2014
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Zhong-wei Du, Jianfeng Lu
  • Patent number: 8658424
    Abstract: A method of differentiating embryonic stem cells into oligodendroglial precursor cells and oligodendroglial cells by culturing a population of cells comprising a majority of cells that are characterized by a neural tube-like rosette morphology and are Pax6+/Sox1+ into a population of cells that are PDGFR?+.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: February 25, 2014
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Baoyang Hu, Zhong-Wei Du
  • Patent number: 8597945
    Abstract: A method of differentiating embryonic stem cells into ventral spinal progenitor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of retinoic acid, wherein the cells express Hoxb4, but not Otx2 or Bf1.
    Type: Grant
    Filed: February 27, 2012
    Date of Patent: December 3, 2013
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Xue-Jun Li
  • Publication number: 20130011917
    Abstract: A method of differentiating embryonic stem cells into oligodendroglial precursor cells and oligodendroglial cells by culturing a population of cells comprising a majority of cells that are characterized by a neural tube-like rosette morphology and are Pax6+/Sox1+ into a population of cells that are PDGFR?+.
    Type: Application
    Filed: June 28, 2012
    Publication date: January 10, 2013
    Inventors: Su-Chun Zhang, Baoyang Hu, Zhong-Wei Du
  • Patent number: 8227247
    Abstract: A method of differentiating embryonic stem cells into oligodendroglial precursor cells and oligodendroglial cells by culturing a population of cells comprising a majority of cells that are characterized by a neural tube-like rosette morphology and are Pax6+/Sox1+ into a population of cells that are PDGFR?+.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: July 24, 2012
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Baoyang Hu, Zhong-Wei Du
  • Publication number: 20120184032
    Abstract: A method of differentiating embryonic stem cells into ventral spinal progenitor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1?/Pax6+ in the presence of retinoic acid, wherein the cells express Hoxb4, but not Otx2 or Bf1.
    Type: Application
    Filed: February 27, 2012
    Publication date: July 19, 2012
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Xue-Jun Li