Patents by Inventor Su-Jin Ku

Su-Jin Ku has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10428372
    Abstract: A probe system for real-time quantitative and qualitative analysis of a biomaterial, and a reaction chamber with the probe system, and an analysis method thereof are provided. The probe system, which is included in the reaction chamber having an optically transmissive flat bottom surface and having a test sample accommodated therein, includes a target probe-reporter probe linker accommodated in the reaction chamber and including a target probe, which includes a sequence complementary to a target nucleic acid sequence to be detected, a first fluorophore and a first quencher, and a reporter probe linked to an end of the target probe and including a sequence non-complementary to the target nucleic acid sequence, and a capture probe included in a biochip formed on a bottom surface of the reaction chamber and including a complementary sequence hybridizable with the non-complementary sequence of the reporter probe, a second fluorophore and a second quencher.
    Type: Grant
    Filed: January 26, 2015
    Date of Patent: October 1, 2019
    Assignee: SUGENTECH, INC.
    Inventors: Lee Kyung Kim, Mun Cheol Paek, Su Jin Ku, Sun Young Park, Jong Pil Park, Do Bu Lee, Nam Joong Kim, Jin Seok Noh
  • Patent number: 10364459
    Abstract: A method of quantitatively and qualitatively analyzing a biomaterial in real-time, the method comprising preparing a device for detecting a biomaterial, feeding a complex of first and second probes, a forward primer, a reverse primer, a sample comprising deoxynucleotide triphosphate, a polymerase having exonuclease activity, and a sample comprising target genes, and a reaction solution comprising a buffer into the reaction container, performing polymerase chain reaction comprising denaturation of the target genes in the sample, hybridization of the target genes, the complex, and the forward and reverse primers in the sample, and elongation of the primers through the polymerase having exonuclease activity, allowing for elongation of the second probe on the third probe by the polymerase after hybridizing the released second probe and the third probe fixed to the biochip, detecting a first fluorescence signal by the first phosphor and a second fluorescence signal by the second phosphor.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: July 30, 2019
    Assignee: SUGENTECH, Inc.
    Inventors: Lee-Kyung Kim, Mun-Cheol Paek, Su-Jin Ku, Sun-Young Park, Do-Bu Lee, Jae-Hyung Park, Ki-Chang Lee, Nam-Joong Kim
  • Publication number: 20170327878
    Abstract: A probe system for real-time quantitative and qualitative analysis of a biomaterial, and a reaction chamber with the probe system, and an analysis method thereof are provided. The probe system, which is included in the reaction chamber having an optically transmissive flat bottom surface and having a test sample accommodated therein, includes a target probe-reporter probe linker accommodated in the reaction chamber and including a target probe, which includes a sequence complementary to a target nucleic acid sequence to be detected, a first fluorophore and a first quencher, and a reporter probe linked to an end of the target probe and including a sequence non-complementary to the target nucleic acid sequence, and a capture probe included in a biochip formed on a bottom surface of the reaction chamber and including a complementary sequence hybridizable with the non-complementary sequence of the reporter probe, a second fluorophore and a second quencher.
    Type: Application
    Filed: January 26, 2015
    Publication date: November 16, 2017
    Applicant: K-MAC BIO CENTER CORP.
    Inventors: Lee Kyung Kim, Mun Cheol Paek, Su Jin Ku, Sun Young Park, Jong Pil Park, Do Bu Lee, Nam Joong Kim, Jin Seok Noh
  • Patent number: 9551038
    Abstract: Provided are a system for integrated analysis of a real-time polymerase chain reaction and a DNA chip and a method for integrated analysis using the same, and more particularly to an apparatus for integrated analysis of a real-time polymerase chain reaction and a DNA chip and a method for integrated analysis using the same. According to the method for integrated analysis of a biomaterial of the present invention, gene amplification proceeds and subsequently hybridization proceeds in a single reactor, thereby preventing contamination of the sample due to external factors, which may be caused while the sample is transferred for reaction, and automating a series of procedures such as injection of the sample, reaction of the biomaterial, and detection and analysis of results.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: January 24, 2017
    Assignee: K-MAC
    Inventors: Sung-Min Seo, Do-Bu Lee, Joong Hwan Lee, Mun-Cheol Paek, Su-Jin Ku
  • Publication number: 20160186236
    Abstract: A method of quantitatively and qualitatively analyzing a biomaterial in real-time, the method comprising preparing a device for detecting a biomaterial, feeding a complex of first and second probes, a forward primer, a reverse primer, a sample comprising deoxynucleotide triphosphate, a polymerase having exonuclease activity, and a sample comprising target genes, and a reaction solution comprising a buffer into the reaction container, performing polymerase chain reaction comprising denaturation of the target genes in the sample, hybridization of the target genes, the complex, and the forward and reverse primers in the sample, and elongation of the primers through the polymerase having exonuclease activity, allowing for elongation of the second probe on the third probe by the polymerase after hybridizing the released second probe and the third probe fixed to the biochip, detecting a first fluorescence signal by the first phosphor and a second fluorescence signal by the second phosphor.
    Type: Application
    Filed: May 30, 2014
    Publication date: June 30, 2016
    Inventors: Lee-Kyung KIM, Mun-Cheol PAEK, Su-Jin KU, Sun-Young PARK, Do-Bu LEE, Jae-Hyung PARK, Ki-Chang LEE, Nam-Joong KIM
  • Patent number: 8871160
    Abstract: Provided is a biomaterial detecting device for confirming or detecting a biomaterial reaction, and more particularly to a biomaterial detecting device, which is formed in a stick type to thereby be immersed in a tube containing a biomaterial solution to be tested; has an upper portion with a cap structure to thereby induce reaction with a biomaterial, and thus facilitate confirmation and detection of the biomaterial; and is formed in a cap structure to thereby prevent evaporation of a sample and infiltration of an external material at the time of a biomaterial reaction in the tube, and thus improve reliability in analysis.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: October 28, 2014
    Assignee: K-MAC
    Inventors: Sung-Min Seo, Jae-Hyung Park, Oleksandrov Sergiy, Joong Hwan Lee, Mun-Cheol Paek, Su-Jin Ku
  • Publication number: 20130303390
    Abstract: Provided are a system for integrated analysis of a real-time polymerase chain reaction and a DNA chip and a method for integrated analysis using the same, and more particularly to an apparatus for integrated analysis of a real-time polymerase chain reaction and a DNA chip and a method for integrated analysis using the same. According to the method for integrated analysis of a biomaterial of the present invention, gene amplification proceeds and subsequently hybridization proceeds in a single reactor, thereby preventing contamination of the sample due to external factors, which may be caused while the sample is transferred for reaction, and automating a series of procedures such as injection of the sample, reaction of the biomaterial, and detection and analysis of results.
    Type: Application
    Filed: July 20, 2012
    Publication date: November 14, 2013
    Inventors: Sung-Min Seo, Do-Bu Lee, Joong Hwan Lee, Mun-Cheol Paek, Su-Jin Ku
  • Publication number: 20130225445
    Abstract: Provided is a bio-reaction device chip for confirming or detecting a biomaterial reaction, and more particularly, is a bio-reaction device chip, where a plurality of wells are formed in the plate to contain biomaterials to be tested, thereby simultaneously analyzing various targets, and the well is formed to have a structure of two or more steps such that the sample to be tested is contained in the lower well and a protective layer for protecting the sample, such as oil, is contained in the upper well, thereby preventing evaporation of the sample due to heating at the time of the biomaterial reaction, and thus, improving reliability in analysis.
    Type: Application
    Filed: July 20, 2012
    Publication date: August 29, 2013
    Inventors: Sung-Min SEO, Jae-Hyung PARK, Sergiy Oleksandrov, Joong Hwan LEE, Mun·Cheol PAEK, Su-Jin KU
  • Publication number: 20130225453
    Abstract: Provided is a biomaterial detecting device for confirming or detecting a biomaterial reaction, and more particularly to a biomaterial detecting device, which is formed in a stick type to thereby be immersed in a tube containing a biomaterial solution to be tested; has an upper portion with a cap structure to thereby induce reaction with a biomaterial, and thus facilitate confirmation and detection of the biomaterial; and is formed in a cap structure to thereby prevent evaporation of a sample and infiltration of an external material at the time of a biomaterial reaction in the tube, and thus improve reliability in analysis.
    Type: Application
    Filed: July 20, 2012
    Publication date: August 29, 2013
    Inventors: Sung-Min SEO, Jae-Hyung Park, Oleksandrov Sergiy, Joong Hwan Lee, Mun-Cheol Paek, Su-Jin Ku
  • Patent number: 6409830
    Abstract: An organometallic compound of formula LiOR′.(R′O)MR2 is vaporized at a low temperature and employed in a CVD process of a heterometallic oxide film of the LiMO2 type, wherein M is a Group 13 element such as Al or Ga; R is a C1-10 alkyl group; and R′ is a C2-10 alkyl group.
    Type: Grant
    Filed: June 1, 2000
    Date of Patent: June 25, 2002
    Assignee: Korea Research Institute of Chemical Technology
    Inventors: Yun-Soo Kim, Won-Yong Koh, Su-Jin Ku
  • Patent number: 6156916
    Abstract: A novel organometallic compound of formula M[(.mu.-OR').sub.2 M'R.sub.2 ].sub.2 can be vaporized at a low temperature and advantageously employed in the CVD of a heterometallic oxide film of the MM'.sub.2 O.sub.4 type, wherein M is a divalent element such as Be, Mg, Zn or Cd; M' is a Group 13 element such as Al or Ga; and R and R' are each independently a C.sub.1-10 alkyl group, with the proviso that if M is Mg, M' is not Al.
    Type: Grant
    Filed: September 24, 1999
    Date of Patent: December 5, 2000
    Assignee: Korea Institute of Science & Technology
    Inventors: Yun-Soo Kim, Won-Yong Koh, Su-Jin Ku, Chang-Gyoun Kim, Kyu-Sang Yu
  • Patent number: 6063951
    Abstract: Novel magnesium dialkylaluminum alkoxide derivative represented by Mg[(.mu.--OR').sub.2 AlR.sub.2 ].sub.2 wherein R and R' are each a C.sub.1-5 alkyl group and R is not the same as R', preferably magnesium dimethylaluminum isopropoxide, is easily prepared by reacting a trialkylaluminum with an alcohol or an aluminum trialkoxide to obtain a dialkylaluminum alkoxide; reacting the dialkylaluminium alkoxide with an alkali metal alkoxide to obtain an alkali metal dialkylaluminum alkoxide; and reacting the alkali metal dialkylaluminum alkoxide with a magnesium halide. The alkoxide derivative of the present invention can be vaporized at a low temperature, below 70.degree. C. and, therefore, effectively employed in the CVD process of a magnesium aluminate film.
    Type: Grant
    Filed: August 11, 1998
    Date of Patent: May 16, 2000
    Assignee: Korea Research Institute of Technology
    Inventors: Yun-Soo Kim, Won-Yong Koh, Su-Jin Ku
  • Patent number: 5998644
    Abstract: A novel organometallic compound of formula M[(.mu.-OR').sub.2 M'R.sub.2 ].sub.2 can be vaporized at a low temperature and advantageously employed in the CVD of a heterometallic oxide film of the MM'.sub.2 O.sub.4 type, wherein M is a divalent element such as Be, Mg, Zn or Cd; M' is a Group 13 element such as Al or Ga; and R and R' are each independently a C.sub.1-10, alkyl group, with the proviso that if M is Mg, M' is not Al.
    Type: Grant
    Filed: August 11, 1998
    Date of Patent: December 7, 1999
    Assignee: Korea Research Institute of Chemical Technology
    Inventors: Yun-Soo Kim, Won-Yong Koh, Su-Jin Ku, Chang-Gyoun Kim, Kyu-Sang Yu
  • Patent number: 5922405
    Abstract: An aluminum oxide film is economically and conveniently deposited on a substrate by a process which comprises vaporizing a dialkylaluminum alkoxide compound at a temperature ranging from 0 to 25.degree. C. and contacting the resulting vapor with said substrate heated to a temperature ranging from 300 to 600.degree. C.
    Type: Grant
    Filed: May 29, 1998
    Date of Patent: July 13, 1999
    Assignee: Korea Research Institute of Chemical Technology
    Inventors: Yun-Soo Kim, Won-Yong Koh, Su-Jin Ku