Abstract: The present invention relates to a fusion protein comprising a SARS-CoV-2-derived receptor-binding domain and a nucleocapsid protein, and the use thereof. The fusion protein comprising a coronavirus-derived receptor-binding domain and a nucleocapsid protein is highly applicable to a multivalent vaccine composition having greatly improved in-vivo half-life and remarkably superior efficacy compared to an immunogenic composition comprising only a receptor-binding domain. In particular, the fusion protein can greatly improve the titer of the coronavirus-specific antibody formation and T-cell immune response, and is thus useful for the prevention and treatment of coronaviruses comprising SARS-CoV-2.

Abstract: Provided is a fluorescent compound for detecting a biomaterial having the following Chemical Formula 1: In Chemical Formula 1 above, R1 and R5 are the same as or different from each other, and each independently selected from H, —SO3- and SO3H, R2 and R6 are the same as each other or each independently selected from hydrogen or methyl R4 and R8 are the same as or different from each other, and each independently selected from H, —SO3- and (CH2)SO3H, R3 and R4 can form alkylene chain with arbituary-substituted 3 carbons combined with the nitrogen atom attached with R3, R7 and R8 can form alkylene chain with arbituary-substituted 3 carbons combined with the nitrogen atom attached with R7, when R8 and R8 do not form alkylene chain, R6, R7 and R8 are hydrogen at the same time and the nitrogen atom attached with R6 and R7 at the same time forms double bond with the carbon of mother molecule and has positive charge.

Abstract: Provided is a fluorescent compound for labeling a biomaterial having the following Chemical Formula 1: In Chemical Formula 1 above, X1 and X2 are the same as or different from each other, and each independently selected from H, —SO3? and SO3H, R1 and R2 are the same as each other or each independently selected from C1-7 alkyl, C8-18 alkyl, —(CH2)mSO3?, —(CH2)mSO3H, and R3 and R4 are the same as or different from each other and each independently selected from C1-7 alkyl, —(CH2)mCOOZ and R3 and R4 are simultaneously not any one selected from —(CH2)mCOOZ and

Abstract: The novel intercalating fluorescent compounds of exemplary embodiments of the present invention for analyzing nucleic acids, etc. have excellent intercalating efficiency with nucleic acids such as DNA and RNA of biomaterials, and may not only continuously maintain fluorescence properties and efficiency, but also have excellent effects even in terms of storage stability such as temperature and moisture, etc. and biosafety. In addition, the fluorescent compounds have various advantages capable of being dissolved in distilled water, which is a solvent harmless to the human body, and being applied to a wide range of analysis without being limited to the analysis of specific cells and living tissues.

Abstract: The novel intercalating fluorescent compounds of exemplary embodiments of the present invention for analyzing nucleic acids, etc. have excellent intercalating efficiency with nucleic acids such as DNA and RNA of biomaterials, and may not only continuously maintain fluorescence properties and efficiency, but also have excellent effects even in terms of storage stability such as temperature and moisture, etc. and biosafety. In addition, the fluorescent compounds have various advantages capable of being dissolved in distilled water, which is a solvent harmless to the human body, and being applied to a wide range of analysis without being limited to the analysis of specific cells and living tissues.

Abstract: Provided is a fluorescent compound represented by the following [Chemical Formula 1] and a method for preparing the same: wherein each of X, Y, R1, R2, R3 and n is the same as defined in the specification.

Abstract: Provided is a fluorescent compound represented by the following [Chemical Formula 1] and a method for preparing the same: wherein each of X, Y, R1, R2, R3 and n is the same as defined in the specification.