Abstract: The present invention relates to a fusion protein comprising a SARS-CoV-2-derived receptor-binding domain and a nucleocapsid protein, and the use thereof. The fusion protein comprising a coronavirus-derived receptor-binding domain and a nucleocapsid protein is highly applicable to a multivalent vaccine composition having greatly improved in-vivo half-life and remarkably superior efficacy compared to an immunogenic composition comprising only a receptor-binding domain. In particular, the fusion protein can greatly improve the titer of the coronavirus-specific antibody formation and T-cell immune response, and is thus useful for the prevention and treatment of coronaviruses comprising SARS-CoV-2.

Abstract: The preset invention relates to a novel 8-oxoprotoberberine derivative or a pharmaceutically acceptable salt thereof, a preparation method thereof, and a pharmaceutical composition for preventing or treating diseases associated with the activity of NFAT5 containing the same as an active ingredient. The novel 8-oxoproteoberberine derivative or the pharmaceutically acceptable salt thereof according to the present invention can be useful in a pharmaceutical composition for preventing or treating diseases associated with the activity of NFAT5, particularly rheumatoid arthritis or inflammatory diseases, since it is ascertained that the derivative or a pharmaceutically acceptable salt thereof has remarkably increased oral absorption compared with known protoberberine due to an improvement in the properties thereof, and inhibits the activity of NFAT5 and the secretion of inflammatory cytokines and reduces the expression of NAFT5 in mice with rheumatoid arthritis by directly inhibiting the transcription of NFT5.

Abstract: The preset invention relates to a novel 8-oxoprotoberberine derivative or a pharmaceutically acceptable salt thereof, a preparation method thereof, and a pharmaceutical composition for preventing or treating diseases associated with the activity of NFAT5 containing the same as an active ingredient. The novel 8-oxoproteoberberine derivative or the pharmaceutically acceptable salt thereof according to the present invention can be useful in a pharmaceutical composition for preventing or treating diseases associated with the activity of NFAT5, particularly rheumatoid arthritis or inflammatory diseases, since it is ascertained that the derivative or a pharmaceutically acceptable salt thereof has remarkably increased oral absorption compared with known protoberberine due to an improvement in the properties thereof, and inhibits the activity of NFAT5 and the secretion of inflammatory cytokines and reduces the expression of NAFT5 in mice with rheumatoid arthritis by directly inhibiting the transcription of NFT5.

Abstract: Embodiments relate to a display device for enhancing image quality. The disclosed display device includes: a display panel configured to display an image; a Poly-Vinyl Acetate (PVA) layer configured to linearly polarize external light; and a Quarter Wave Plate (QWP) configured to circularly polarize light where the QWP has an in-plane retardation value of below 140 nm.

Abstract: Provided are a digital photographing apparatus and method of performing different degrees of image processing on one or more faces in an image according to the distances of faces from the digital photographing apparatus or whether auto-focusing has been performed on the faces. Also provided are a digital photographing apparatus and method of performing different degrees of image processing which assist in preventing faces at farther distances from appearing more processed, for example, more blurred, than faces at closer distances and which assist in preventing faces that have not been auto-focused from appearing more processed, for example, more blurred, than faces that have been auto-focused.

Abstract: A method of controlling a photographing apparatus is provided that includes: setting a first exposure time according to a user's input; determining a number of times photographing is performed according to an illuminance and the first exposure time; continuously capturing a plurality of still images the number of times photographing is performed; and generating a resultant image corresponding to the first exposure time by combining the captured plurality of still images.

Abstract: Provided are a digital photographing apparatus and method of performing different degrees of image processing on one or more faces in an image according to the distances of faces from the digital photographing apparatus or whether auto-focusing has been performed on the faces. Also provided are a digital photographing apparatus and method of performing different degrees of image processing which assist in preventing faces at farther distances from appearing more processed, for example, more blurred, than faces at closer distances and which assist in preventing faces that have not been auto-focused from appearing more processed, for example, more blurred, than faces that have been auto-focused.

Abstract: Provided are a digital photographing apparatus and method of performing different degrees of image processing on one or more faces in an image according to the distances of faces from the digital photographing apparatus or whether auto-focusing has been performed on the faces. Also provided are a digital photographing apparatus and method of performing different degrees of image processing which assist in preventing faces at farther distances from appearing more processed, for example, more blurred, than faces at closer distances and which assist in preventing faces that have not been auto-focused from appearing more processed, for example, more blurred, than faces that have been auto-focused.

Abstract: A liquid crystal display and a method of manufacturing the same that can reduce the increase in the black level due to light leakage, without reducing the aperture ratio while improving the contrast ratio.

Abstract: Provided are a digital photographing apparatus and method of performing different degrees of image processing on one or more faces in an image according to the distances of faces from the digital photographing apparatus or whether auto-focusing has been performed on the faces. Also provided are a digital photographing apparatus and method of performing different degrees of image processing which assist in preventing faces at farther distances from appearing more processed, for example, more blurred, than faces at closer distances and which assist in preventing faces that have not been auto-focused from appearing more processed, for example, more blurred, than faces that have been auto-focused.

Abstract: A digital image processing apparatus and method are provided, particularly, a digital image processing apparatus having a self-navigator function for allowing capture of a self-image with a user-desired composition, and an operation method of the digital image processing apparatus. The digital image processing apparatus includes a digital signal processing unit for setting a desired position at which a subject is to be positioned on a live-view image and directing the subject to move until an actual position of the subject corresponds to the desired position.

Abstract: The present invention relates to a modified CpG oligodeoxynucleotide (ODN) which is prepared by coupling a consecutive sequence of deoxyribothymine (dT) to the 3?-terminus of CpG ODN having immunoregularory function, thereby improving immunoactivity of splenocytes, macrophages and peripheral mononuclear cells, and therefore, can be effectively used as a vaccine adjuvant for preventing and treating hepatitis B or an anticancer agent. Since the phosphorothioate CpG ODN having the consecutive sequence of dT at its 3?-terminus shows high activity inducing Th-1 immune response and does not elicit in vivo toxicity with guaranteeing its safety, it can be effectively used as a vaccine adjuvant.

Abstract: The present invention relates to a modified CpG oligodeoxynucleotide (ODN) which is prepared by coupling a consecutive sequence of deoxyribothymine (dT) to the 3?-terminus of CpG ODN having immunoregularory function, thereby improving immunoactivity of splenocytes, macrophages and peripheral mononuclear cells, and therefore, can be effectively used as a vaccine adjuvant for preventing and treating hepatitis B or an anti-cancer agent. Since the phosphorothioate CpG ODN having the consecutive sequence of dT at its 3?-terminus shows high activity inducing Th-1 immune response and does not elicit in vivo toxicity with guaranteeing its safety, it can be effectively used as a vaccine adjuvant.