Abstract: The present disclosure relates to an anti-FcRn antibody or an antigen binding fragment thereof with improved stability and uses thereof. The anti-FcRn antibody or antigen binding fragment thereof binds to FcRn non-competitively with IgG and the like compared to the parent antibody, HL161AN, thereby having improved stability, such as reducing the production rate of aggregates while maintaining the biological activity of significantly reducing the amount of pathogenic autoantibodies in the blood. Therefore, it may be utilized more efficiently for the treatment of an autoimmune disease.

Abstract: The present disclosure relates to an anti-FcRn antibody or an antigen binding fragment thereof with improved stability and uses thereof. The anti-FcRn antibody or antigen binding fragment thereof binds to FcRn non-competitively with IgG and the like compared to the parent antibody, HL161AN, thereby having improved stability, such as reducing the production rate of aggregates while maintaining the biological activity of significantly reducing the amount of pathogenic autoantibodies in the blood. Therefore, it may be utilized more efficiently for the treatment of an autoimmune disease.

Abstract: Various blends of polymers are disclosed, comprising oligopeptide functionalised polymers such as polyisobutylene and polystyrene. Mono-functionalised and di-functionalised polymers (each containing 0 to 5 peptide units beyond its terminal amide group) may be blended with each other and/or with non-functionalised polymers to produce blended compositions. Such compositions are of use, for example, in vibrations dampers. Certain blends also exhibit self-healing properties.

Abstract: Various blends of polymers are disclosed, comprising oligopeptide functionalised polymers such as polyisobutylene and polystyrene. Mono-functionalised and di-functionalised polymers (each containing 0 to 5 peptide units beyond its terminal amide group) may be blended with each other and/or with non-functionalised polymers to produce blended compositions. Such compositions are of use, for example, in vibrations dampers. Certain blends also exhibit self-healing properties.

Abstract: The present invention discloses a current balancing device and method capable of balancing an output current and an input current of a current loop. Said device comprises: a transmission circuit for outputting an output current and receiving an input current; at least one adjustable resistor set in the current loop for providing resistance according to at least one adjustment signal; and a current balancing circuit, coupled to the transmission circuit and the adjustable resistor, for determining whether the difference between the output and input currents satisfies a predetermined requirement in light of a predetermined duration and thereby generating the adjustment signal, wherein if the difference between the output and input currents fails to satisfy the predetermined requirement, the current balancing circuit will adjust the resistance of the adjustable resistor through the adjustment signal, so as to reduce the difference between the output and input currents.

Abstract: Liposomes comprising an FKBP52 targeting agent (FTA) are disclosed. Pharmaceutical compositions comprising an FTA, a solvent, and a surfactant are disclosed. Pharmaceutical compositions comprising a cyclodextrin and/or a derivative thereof and an FTA are also disclosed. Method of detecting one or more compounds in a sample by liquid chromatography/tandem mass spectrometry (LC/MS/MS), methods of treating or preventing cancer, benign prostatic hyperplasia (BPH), prostatic intraepithelial neoplasia (PIN), prostatitis, enlarged prostate, or insulin-independent diabetes, and methods of inhibiting spermatogenesis or fertilized oocyte implantation in a mammal are also provided.

Abstract: Various blends of polymers are disclosed, comprising oligopeptide functionalised polymers such as polyisobutylene and polystyrene. Mono-functionalised and di-functionalised polymers (each containing 0 to 5 peptide units beyond its terminal amide group) may be blended with each other and/or with non-functionalised polymers to produce blended compositions. Such compositions are of use, for example, in vibrations dampers. Certain blends also exhibit self-healing properties.

Abstract: A communication apparatus and an associated estimation method are provided. The communication apparatus is electrically connected to a loading terminal and operates at a common bias voltage. The communication apparatus includes a transmitter, a connector, and a receiver. The connector includes a bridging circuit and a measurement circuit. The bridging circuit has a positive measurement end and a negative measurement end. The transmitter transmits an analog output signal. The receiver receives a common bias voltage during an estimation process. During the estimation process, the measurement circuit estimates a positive loading resistance and a negative loading resistance corresponding to the loading terminal according to a voltage difference between the common bias voltage and voltage at one of the positive measurement end and the negative measurement end.

Abstract: The present invention discloses a current balancing device and method capable of balancing an output current and an input current of a current loop. Said device comprises: a transmission circuit for outputting an output current and receiving an input current; at least one adjustable resistor set in the current loop for providing resistance according to at least one adjustment signal; and a current balancing circuit, coupled to the transmission circuit and the adjustable resistor, for determining whether the difference between the output and input currents satisfies a predetermined requirement in light of a predetermined duration and thereby generating the adjustment signal, wherein if the difference between the output and input currents fails to satisfy the predetermined requirement, the current balancing circuit will adjust the resistance of the adjustable resistor through the adjustment signal, so as to reduce the difference between the output and input currents.

Abstract: A transmission line driver and a method for driving the same are provided, in which a composite current source is provided as an input current source, such that an output voltage is fixed. The composite current source includes an internal current source and an external current source. The composite current source is supplied to a single-ended transmission line driver or a differential transmission line driver, such that the output voltage is fixed.

Abstract: A communication apparatus and an associated estimation method are provided. The communication apparatus is electrically connected to a loading terminal and operates at a common bias voltage. The communication apparatus includes a transmitter, a connector, and a receiver. The connector includes a bridging circuit and a measurement circuit. The bridging circuit has a positive measurement end and a negative measurement end. The transmitter transmits an analog output signal. The receiver receives a common bias voltage during an estimation process. During the estimation process, the measurement circuit estimates a positive loading resistance and a negative loading resistance corresponding to the loading terminal according to a voltage difference between the common bias voltage and voltage at one of the positive measurement end and the negative measurement end.

Abstract: A transceiving circuit resistance calibrating method, which is applied to a transceiving circuit. The method includes: inputting a first current to a transmitter to generate a first output voltage, wherein the first current is generated according to a ratio between a predetermined voltage and an inner resistor of a chip; inputting a second current to a transmitter to generate a second output voltage, wherein the first current is generated according to a ratio between the predetermined voltage and a predetermined resistor; and adjusting a first adjustable resistance module according to a difference between the first output voltage and the second output voltage.

Abstract: Aspects of the invention relate to block copolymers having the properties of thermoplastic elastomers made of blocks on the basis of isobutene monomer units as the soft segment and blocks on the basis of oligoamides composed of at least two base units, each of which comprises an amino or a carbonyl group in the ?, ?, ? or ? position to each other or directly bound to each other, as the hard segment. Such block copolymers are suited for producing fibers, microfibers, and films.

Abstract: A transceiving circuit resistance calibrating method, which is applied to a transceiving circuit. The method includes: inputting a first current to a transmitter to generate a first output voltage, wherein the first current is generated according to a ratio between a predetermined voltage and an inner resistor of a chip; inputting a second current to a transmitter to generate a second output voltage, wherein the first current is generated according to a ratio between the predetermined voltage and a predetermined resistor; and adjusting a first adjustable resistance module according to a difference between the first output voltage and the second output voltage.

Abstract: Systems and methods are described for transmitting a waveform having a controllable attenuation and propagation velocity. An exemplary method comprises: generating an exponential waveform, the exponential waveform (a) being characterized by the equation Vin=De?ASD[x?vSDt], where D is a magnitude, Vin is a voltage, t is time, ASD is an attenuation coefficient, and vSD is a propagation velocity; and (b) being truncated at a maximum value. An exemplary apparatus comprises: an exponential waveform generator; an input recorder coupled to an output of the exponential waveform generator; a transmission line under test coupled to the output of the exponential waveform generator; an output recorder coupled to the transmission line under test; an additional transmission line coupled to the transmission line under test; and a termination impedance coupled to the additional transmission line and to a ground.

Abstract: A line driver includes an output terminal set for outputting an output signal, a differential amplifier for amplifying an input signal, a series resistor set coupled between the differential amplifier and the output terminal set, a negative-feedback resistor set coupled to the differential amplifier, a feedback variable resistor set coupled between the differential amplifier and the output terminal set, and an adjusting unit coupled to the feedback variable resistor set. The adjusting unit is operable to adjust resistances of the feedback variable resistor set according to the output signal.

Abstract: A transmission line driver and a method for driving the same are provided, in which a composite current source is provided as an input current source, such that an output voltage is fixed. The composite current source includes an internal current source and an external current source. The composite current source is supplied to a single-ended transmission line driver or a differential transmission line driver, such that the output voltage is fixed.

Abstract: Systems and methods are described for transmitting a waveform having a controllable attenuation and propagation velocity. An exemplary method comprises: generating an exponential waveform, the exponential waveform (a) being characterized by the equation Vin=De?ASD[x?vSDt], where D is a magnitude, Vin is a voltage, t is time, ASD is an attenuation coefficient, and vSD is a propagation velocity; and (b) being truncated at a maximum value. An exemplary apparatus comprises: an exponential waveform generator; an input recorder coupled to an output of the exponential waveform generator; a transmission line under test coupled to the output of the exponential waveform generator; an output recorder coupled to the transmission line under test; an additional transmission line coupled to the transmission line under test; and a termination impedance coupled to the additional transmission line and to a ground.

Abstract: A line driver includes an output terminal set for outputting an output signal, a differential amplifier for amplifying an input signal, a series resistor set coupled between the differential amplifier and the output terminal set, a negative-feedback resistor set coupled to the differential amplifier, a feedback variable resistor set coupled between the differential amplifier and the output terminal set, and an adjusting unit coupled to the feedback variable resistor set. The adjusting unit is operable to adjust resistances of the feedback variable resistor set according to the output signal.

Abstract: A line driver includes: a differential amplifier for amplifying an input signal to generate an output signal; first and second series resistors coupled respectively to output terminals of the differential amplifier and through which the output signal is output; first and second negative-feedback resistors each coupled between a respective input terminal and a respective output terminal of the differential amplifier; first and second positive-feedback variable resistors each coupled between a respective input terminal of the differential amplifier and a respective one of the first and second series resistors; and an adjusting unit coupled to the first and second positive-feedback variable resistors to adjust a resistance thereof with reference to the output signal.