Abstract: The present invention relates to novel mesylate salt of N-(5-(4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidine-2-ylamino)-4-methoxy-2-morpholinophenyl)acrylamide, a novel crystalline form thereof, and a process for preparing the same. More specifically, the present invention relates to mesylate salt of N-(5-(4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidine-2-ylamino)-4-methoxy-2-morpholinophenyl)acrylamide, which is excellent in stability, solubility, and bioavailability when it is administered not only alone but also in combination with other drugs and which has a high purity, a crystalline form thereof, and a process for preparing the same.

Abstract: The present invention relates to a novel p62 ligand compound, a stereoisomer, hydrate, solvate or prodrug thereof, and a pharmaceutical or food composition for preventing or treating proteinopathies comprising the same as an active ingredient. The p62 ligand compound according to the present invention can be usefully used as a pharmaceutical composition for the prevention, amelioration or treatment of various proteinopathies by activating autophagy in cells and thus selectively eliminating in vivo proteins, organelles and aggregates.

Abstract: The present disclosure relates to a multi-organ model, and the multi-organ model of the present disclosure is excellent in culturing each organoid due to linkage between organoids and properties of hydrogel and can more accurately reflect the interactions between organs and the microenvironment in vivo. Also, the multi-organ model is further subjected to free fatty acid treatment and thus can more accurately mimic the phenotypes of non-alcoholic fatty liver. Accordingly, it is possible to analyze the effects of candidate drugs on peripheral organs.

Abstract: A phenol derivative-modified, tissue-derived extracellular matrix derivative for construction of artificial tissues. A hydrogel composition and a hydrogel prepared therefrom exhibit various effects such as hemostasis, blood coagulation acceleration, cell transplantation, drug delivery, cell differentiation promotion, etc. and thus can be applied to single or composite uses. Furthermore, the present invention is excellent in biocompatibility due to its biodegradability and being almost free of cytotoxicity, thus exhibiting very high applicability. In addition, a tissue structure including a single type or multiple types of cells can be formed through the cell-proliferating potential and adhesion of the hydrogel and can better simulate in-vivo microenvironments.

Abstract: Provided is an asphalt modifier for an asphalt mixture and an asphalt mixture containing the same, and more particularly, to an asphalt modifier in which a coating layer containing low-melting-point polyethylene and an inorganic material is formed on a reinforcing fiber bundle. Preferably, the asphalt modifier according to the present disclosure is intended to be mixed with aggregate and an asphalt binder, and comprises: a reinforcing fiber bundle having a length of 8 to 34 mm and composed of a plurality of reinforcing fiber strands; and a coating layer forming the envelope of the reinforcing fiber bundle and comprising polyethylene and an inorganic material.

Abstract: The present disclosure relates to a decellularized adipose tissue-derived scaffold and a method of preparing the same. The scaffold of the present disclosure can be applied to culture of various types of organoids and thus can be used in various fields due to its high versatility. Also, the scaffold of the present disclosure can be prepared from a human adipose tissue to be discarded and thus can create enormous added value. Further, the scaffold of the present disclosure can be widely used in the medical industry, such as new drug development, drug toxicity and efficacy evaluation, and patient-specific drug selection, in substitution for conventional Matrigel.

Abstract: Provided is an asphalt modifier for an asphalt mixture and an asphalt mixture containing the same, and more particularly, to an asphalt modifier in which a coating layer containing low-melting-point polyethylene and an inorganic material is formed on a reinforcing fiber bundle. Preferably, the asphalt modifier according to the present disclosure is intended to be mixed with aggregate and an asphalt binder, and comprises: a reinforcing fiber bundle having a length of 8 to 34 mm and composed of a plurality of reinforcing fiber strands; and a coating layer forming the envelope of the reinforcing fiber bundle and comprising polyethylene and an inorganic material.

Abstract: The present disclosure relates to a scaffold for culturing and transplanting a cardiac organoid by using a heart extracellular matrix (HEM).

Abstract: The present disclosure relates to an organ extracellular matrix-derived scaffold for culture and transplantation of an organoid and a method of preparing the same.

Abstract: Provided is an asphalt modifier for an asphalt mixture and an asphalt mixture containing the same, and more particularly, to an asphalt modifier in which a coating layer containing low-melting-point polyethylene and an inorganic material is formed on a reinforcing fiber bundle. Preferably, the asphalt modifier according to the present disclosure is intended to be mixed with aggregate and an asphalt binder, and comprises: a reinforcing fiber bundle having a length of 8 to 34 mm and composed of a plurality of reinforcing fiber strands; and a coating layer forming the envelope of the reinforcing fiber bundle and comprising polyethylene and an inorganic material.

Abstract: The present invention relates to: a pharmaceutical composition for preventing or treating menopausal disorders, containing a Tetragonia tetragonoides (Pall.) Kuntze extract or a fraction thereof; a method for preventing or treating menopausal disorders, comprising a step of administering the pharmaceutical composition; and a food composition containing the extract or a fraction thereof. The Tetragonia tetragonoides (Pall.) Kuntze extract of the present invention shows effects of alleviating obesity, which is representative of glucose metabolism disorders and lipid metabolism disorders, osteoporosis, which is representative of bone homeostasis disorders, and flushing, which is representative of energy metabolism disorders, and thus the extract can be used in food, a medicine and the like so as to prevent, alleviate or treat menopausal disorders.