Abstract: A system and method for determining a mesh layout and manufacturing an implantable mesh. A support surface with pins is provided in a configuration that corresponds to the mesh layout. A biocompatible filament is wound around the pins to provide a macroporous mesh. The completed weave is treated with a solution to bond intersection points of filament, then sterilized and packaged to provide an implantable mesh.

Abstract: A small diameter, multi-channel endoscope for pain management in a subject includes a control handle and a flexible, elongated body functionally connected to the control handle. The body includes a distal end for positioning in or about a target structure. The body also includes a working channel that extends longitudinally through the body. The working channel includes a controllable deployment mechanism configured for selective application of at least one target substance to the target structure. Additionally, the body includes an image channel extending longitudinally through the body. The image channel includes a visualization system for conveying an image from the distal end of the body to a user.