Patents by Inventor Subbarao Nallagatla

Subbarao Nallagatla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
    Patent number: 11957788
    Abstract: Liposomal spherical nucleic acids that function as multivalent immune modulators are provided according to the invention. The liposomal spherical nucleic acids of the invention are useful prophylactic and therapeutic applications as well as research and diagnostic indications.
    Type: Grant
    Filed: August 18, 2021
    Date of Patent: April 16, 2024
    Assignee: Exicure Operating Company
    Inventors: Aleksandar Filip Radovic-Moreno, Richard Kang, Subbarao Nallagatla, Christopher C. Mader, Sergei Gryaznov
  • Synthesis of spherical nucleic acids using lipophilic moieties
    Patent number: 11696954
    Abstract: Spherical nucleic acids (SNA) carrying self-aggregating oligonucleotides are described herein. Compositions of the SNA include discrete nanostructures that are not aggregated. Related methods are also described.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: July 11, 2023
    Assignee: Exicure Operating Company
    Inventors: Richard Kang, Subbarao Nallagatla, Bart Anderson, Ekambar Kandimalla
  • MULTIVALENT DELIVERY OF IMMUNE MODULATORS BY LIPOSOMAL SPHERICAL NUCLEIC ACIDS FOR PROPHYLACTIC OR THERAPEUTIC APPLICATIONS
    Publication number: 20220257512
    Abstract: Liposomal spherical nucleic acids that function as multivalent immune modulators are provided according to the invention. The liposomal spherical nucleic acids of the invention are useful prophylactic and therapeutic applications as well as research and diagnostic indications.
    Type: Application
    Filed: August 18, 2021
    Publication date: August 18, 2022
    Applicant: Exicure Operating Company
    Inventors: Aleksandar Filip Radovic-Moreno, Richard Kang, Subbarao Nallagatla, Christopher C. Mader, Sergei Gryaznov
  • SPHERICAL NUCLEIC ACID TLR9 AGONISTS
    Publication number: 20220064649
    Abstract: Aspects of the invention relate to compositions of spherical nucleic acids (SNAs) composed of a liposome or lipoplex complex having an oligonucleotide shell with CpG oligonucleotides positioned on the exterior of the liposome or lipoplex. The invention also relates to methods of treating subjects and of inducing cytokine expression in a subject using the compositions described herein.
    Type: Application
    Filed: April 15, 2021
    Publication date: March 3, 2022
    Applicant: Exicure, Inc.
    Inventors: Bart Anderson, Subbarao Nallagatla, Richard Kang, Ekambar Kandimalla
  • Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
    Patent number: 11123294
    Abstract: Liposomal spherical nucleic acids that function as multivalent immune modulators are provided according to the invention. The liposomal spherical nucleic acids of the invention are useful prophylactic and therapeutic applications as well as research and diagnostic indications.
    Type: Grant
    Filed: September 12, 2019
    Date of Patent: September 21, 2021
    Assignee: Exicure Operating Company
    Inventors: Aleksandar Filip Radovic-Moreno, Richard Kang, Subbarao Nallagatla, Christopher C. Mader, Sergei Gryaznov
  • SPHERICAL NUCLEIC ACID-BASED CONSTRUCTS AS IMMUNOSTIMULATORY AGENTS FOR PROPHYLACTIC AND THERAPEUTIC USE
    Publication number: 20210102211
    Abstract: Aspects of the invention relate to spherical nucleic acid-based constructs and related methods and compositions thereof.
    Type: Application
    Filed: October 8, 2020
    Publication date: April 8, 2021
    Applicant: Exicure, Inc.
    Inventors: Aleksandar Filip Radovic-Moreno, Christopher C. Mader, Subbarao Nallagatla, Warefta Hasan, Aaron Love, Sergei Gryaznov
  • Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use
    Patent number: 10894963
    Abstract: Aspects of the invention relate to spherical nucleic acid-based constructs and related methods and compositions thereof.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: January 19, 2021
    Assignee: Exicure, Inc.
    Inventors: Aleksandar Filip Radovic-Moreno, Christopher C. Mader, Subbarao Nallagatla, Warefta Hasan, Aaron Love, Sergei Gryaznov
  • LIPOSOMAL SPHERICAL NUCLEIC ACID (SNA) CONSTRUCTS FOR SURVIVAL OF MOTOR NEURON (SMA) INHIBITORS
    Publication number: 20210002640
    Abstract: Compositions related to spherical nucleic acids (SNAs) and structures with antisense oligonucleotides and methods of treatment of diseases and disorders are disclosed herein.
    Type: Application
    Filed: February 28, 2019
    Publication date: January 7, 2021
    Applicant: Exicure, Inc.
    Inventors: Richard Kang, Subbarao Nallagatla, Bart Anderson, Ekambar Kandimalla, Michael Mutolo
  • Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use
    Patent number: 10837018
    Abstract: Aspects of the invention relate to spherical nucleic acid-based constructs and related methods and compositions thereof. The compositions of the invention are useful for activating agonists of nucleic acid interacting complexes, such as TLRs, stimulating an immune response, and treating diseases such as infectious disease, cancer, allergies, allergic diseases, and autoimmune disease.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: November 17, 2020
    Assignee: Exicure, Inc.
    Inventors: Aleksandar Filip Radovic-Moreno, Christopher C. Mader, Subbarao Nallagatla, Warefta Hasan, Aaron Love, Sergei Gryaznov
  • SPHERICAL NUCLEIC ACID TLR9 AGONISTS
    Publication number: 20200255837
    Abstract: Aspects of the invention relate to compositions of spherical nucleic acids (SNAs) composed of a liposome or lipoplex complex having an oligonucleotide shell with CpG oligonucleotides positioned on the exterior of the liposome or lipoplex. The invention also relates to methods of treating subjects and of inducing cytokine expression in a subject using the compositions described herein.
    Type: Application
    Filed: May 5, 2017
    Publication date: August 13, 2020
    Applicant: Exicure, Inc.
    Inventors: Bart Anderson, Subbarao Nallagatla, Richard Kang, Ekambar Kandimalla
  • TLR9-TARGETED SPHERICAL NUCLEIC ACIDS HAVING POTENT ANTITUMOR ACTIVITY
    Publication number: 20200248183
    Abstract: Aspects of the invention relate to immunostimulatory spherical nucleic acids (IS-SNA) for the treatment of a disorder, such as cancer. The IS-SNA may be administered together with a checkpoint inhibitor.
    Type: Application
    Filed: May 5, 2017
    Publication date: August 6, 2020
    Inventors: Subbarao Nallagatla, Bart ANDERSON, Ekambar KANDIMALLA
  • SYNTHESIS OF SPHERICAL NUCLEIC ACIDS USING LIPOPHILIC MOIETIES
    Publication number: 20200188521
    Abstract: Spherical nucleic acids (SNA) carrying self-aggregating oligonucleotides are described herein. Compositions of the SNA include discrete nanostructures that are not aggregated. Related methods are also described.
    Type: Application
    Filed: April 27, 2018
    Publication date: June 18, 2020
    Applicant: Exicure, Inc.
    Inventors: Richard Kang, Subbarao Nallagatla, Bart Anderson, Ekambar Kandimalla
  • MULTIVALENT DELIVERY OF IMMUNE MODULATORS BY LIPOSOMAL SPHERICAL NUCLEIC ACIDS FOR PROPHYLACTIC OR THERAPEUTIC APPLICATIONS
    Publication number: 20200069587
    Abstract: Liposomal spherical nucleic acids that function as multivalent immune modulators are provided according to the invention. The liposomal spherical nucleic acids of the invention are useful prophylactic and therapeutic applications as well as research and diagnostic indications.
    Type: Application
    Filed: September 12, 2019
    Publication date: March 5, 2020
    Applicant: Exicure, Inc.
    Inventors: Aleksandar Filip Radovic-Moreno, Richard Kang, Subbarao Nallagatla, Christopher C. Mader, Sergei Gryaznov
  • Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
    Patent number: 10434064
    Abstract: Liposomal spherical nucleic acids that function as multivalent immune modulators are provided according to the invention. The liposomal spherical nucleic acids of the invention are useful prophylactic and therapeutic applications as well as research and diagnostic indications.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: October 8, 2019
    Assignee: Exicure, Inc.
    Inventors: Aleksandar Filip Radovic-Moreno, Richard Kang, Subbarao Nallagatla, Christopher C. Mader, Sergei Gryaznov
  • SPHERICAL NUCLEIC ACID TLR9 AGONISTS
    Publication number: 20190225968
    Abstract: Aspects of the invention relate to compositions of spherical nucleic acids (SNAs) composed of a liposome or lipoplex complex having an oligonucleotide shell with CpG oligonucleotides positioned on the exterior of the liposome or lipoplex. The invention also relates to methods of treating subjects and of inducing cytokine expression in a subject using the compositions described herein.
    Type: Application
    Filed: May 5, 2017
    Publication date: July 25, 2019
    Applicant: Exicure, Inc.
    Inventors: Bart Anderson, Subbarao Nallagatla, Richard Kang, Ekambar Kandimalla
  • SPHERICAL NUCLEIC ACID-BASED CONSTRUCTS AS IMMUNOSTIMULATORY AGENTS FOR PROPHYLACTIC AND THERAPEUTIC USE
    Publication number: 20180320184
    Abstract: Aspects of the invention relate to spherical nucleic acid-based constructs and related methods and compositions thereof.
    Type: Application
    Filed: May 15, 2018
    Publication date: November 8, 2018
    Applicant: Exicure, Inc.
    Inventors: Aleksandar Filip Radovic-Moreno, Christopher C. Mader, Subbarao Nallagatla, Warefta Hasan, Aaron Love, Sergei Gryaznov
  • IMMUNO-REGULATORY LIPID CONTAINING SPHERICAL NUCLEIC ACIDS
    Publication number: 20180042848
    Abstract: Immunoregulatory spherical nucleic acids (irSNAs) composed of a lipid containing core and an inert Nucleic non-TLR antagonistic oligonucleotide shell are provided. Acid Shell These it-SNAs are useful for modulating an immune response.
    Type: Application
    Filed: February 18, 2016
    Publication date: February 15, 2018
    Applicant: Exicure, Inc.
    Inventors: Sergei Gryaznov, Aleksandar Filip Radovic-Moreno, Christopher C. Mader, Tiffany L. Halo, Richard Kang, Subbarao Nallagatla, Clayton Rische, Sagar Anantatatmula
  • MULTIVALENT DELIVERY OF IMMUNE MODULATORS BY LIPOSOMAL SPHERICAL NUCLEIC ACIDS FOR PROPHYLACTIC OR THERAPEUTIC APPLICATIONS
    Publication number: 20170157048
    Abstract: Liposomal spherical nucleic acids that function as multivalent immune modulators are provided according to the invention. The liposomal spherical nucleic acids of the invention are useful prophylactic and therapeutic applications as well as research and diagnostic indications.
    Type: Application
    Filed: June 4, 2015
    Publication date: June 8, 2017
    Applicant: Exicure, Inc.
    Inventors: Aleksandar Filip Radovic-Moreno, Richard Kang, Subbarao Nallagatla, Christopher C. Mader, Sergei Gryaznov
  • SPHERICAL NUCLEIC ACID-BASED CONSTRUCTS AS IMMUNOSTIMULATORY AGENTS FOR PROPHYLACTIC AND THERAPEUTIC USE
    Publication number: 20160186178
    Abstract: Aspects of the invention relate to spherical nucleic acid-based constructs and related methods and compositions thereof.
    Type: Application
    Filed: July 25, 2014
    Publication date: June 30, 2016
    Applicant: Exicure, Inc.
    Inventors: Aleksandar Filip Radovic-Moreno, Christopher C. Mader, Subbarao Nallagatla, Warefta Hasan, Aaron Love, Sergei Gryaznov