Patents by Inventor Subha Ranjan Das

Subha Ranjan Das has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Extracellular Vesicle Functionalization Using Oligonucleotide Tethers
    Publication number: 20220145291
    Abstract: Provided herein are tethered extracellular vesicles and methods of making tethered extracellular vesicles.
    Type: Application
    Filed: February 14, 2020
    Publication date: May 12, 2022
    Inventors: Subha Ranjan Das, Phil G. Campbell, Krzysztof Matyjaszewski, Sushil Lathwal, Saigopalakrishna Saileelaprasad Yernei
  • Nucleic acid-polymer conjugates for bright fluorescent tags
    Patent number: 10982266
    Abstract: A composition includes a polymer including extending chains, side chains, or branches. One (or more) of a plurality of a first strand of nucleic acid is attached to each of a plurality of the side chains. One (or more) of a plurality of a second strand of nucleic acid, which is complementary to the first strand of nucleic acid, is complexed to each of the plurality of the first strand of nucleic acid to form a double strand of nucleic acid on each of the plurality of the side chains. At least one fluorescent compound is associated with the double strand of nucleic acid on each of the plurality of the side chains.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: April 20, 2021
    Assignee: CARNEGIE MELLON UNIVERSITY
    Inventors: Munira F. Fouz, Krzysztof Matyjaszewski, Bruce A. Armitage, Subha Ranjan Das, Saadyah Averick
  • NUCLEIC ACID-POLYMER CONJUGATES FOR BRIGHT FLUORESCENT TAGS
    Publication number: 20180142288
    Abstract: A composition includes a polymer including extending chains, side chains, or branches. One (or more) of a plurality of a first strand of nucleic acid is attached to each of a plurality of the side chains. One (or more) of a plurality of a second strand of nucleic acid, which is complementary to the first strand of nucleic acid, is complexed to each of the plurality of the first strand of nucleic acid to form a double strand of nucleic acid on each of the plurality of the side chains. At least one fluorescent compound is associated with the double strand of nucleic acid on each of the plurality of the side chains.
    Type: Application
    Filed: November 2, 2017
    Publication date: May 24, 2018
    Inventors: Munira F. Fouz, Krzysztof Matyjaszewski, Bruce A. Armitage, Subha Ranjan Das, Saadyah Averick
  • Functionalized polymer hybrids
    Patent number: 9765169
    Abstract: A method of synthesizing a polynucleotide composition includes attaching a compound including at least one initiator or at least one transfer agent for a reversible deactivation radical polymerization to an end of a nucleotide chain assembly immobilized upon a solid phase support during a solid phase synthesis of a polynucleotide so that the initiator or the transfer agent is attacked to the end of a nucleotide chain assembly in a manner which is stable under conditions of deprotection of the polynucleotide, and growing a polymer from the initiator of from a site of the chain transfer agent via the reversible deactivation radical polymerization to form the polynucleotide composition.
    Type: Grant
    Filed: April 17, 2014
    Date of Patent: September 19, 2017
    Assignee: CARNEGIE MELLON UNIVERSITY
    Inventors: Subha Ranjan Das, Saadyah Averick, Sourav K. Dey, Krzysztof Matyjaszewski
  • FUNCTIONALIZED POLYMER HYBRIDS
    Publication number: 20170152336
    Abstract: A method of synthesizing a polynucleotide composition includes attaching a compound including at least one initiator or at least one transfer agent for a reversible deactivation radical polymerization to an end of a nucleotide chain assembly immobilized upon a solid phase support during a solid phase synthesis of a polynucleotide so that the initiator or the transfer agent is attacked to the end of a nucleotide chain assembly in a manner which is stable under conditions of deprotection of the polynucleotide, and growing a polymer from the initiator of from a site of the chain transfer agent via the reversible deactivation radical polymerization to form the polynucleotide composition.
    Type: Application
    Filed: April 17, 2014
    Publication date: June 1, 2017
    Inventors: SUBHA RANJAN DAS, SAADYAH AVERICK, SOURAV K. DEY, Krzysztof Matyjaszewski
  • Synthetic lariat RNA for RNA interference
    Patent number: 9546364
    Abstract: Provided herein are compositions for the modification of gene expression by RNA interference using a microRNA (miRNA) guide strand precursor. Methods of making and using the miRNA guide strand precursor also are provided. The compositions bypass the Drosha-Exportin-Dicer pathway and are resistant to nucleases.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: January 17, 2017
    Assignee: Carnegie Mellon University
    Inventors: Subha Ranjan Das, Eduardo Paredes
  • FUNCTIONALIZED POLYMER HYBRIDS
    Publication number: 20160075810
    Abstract: A method of synthesizing a polynucleotide composition includes attaching a compound including at least one initiator or at least one transfer agent for a reversible deactivation radical polymerization to an end of a nucleotide chain assembly immobilized upon a solid phase support during a solid phase synthesis of a polynucleotide so that the initiator or the transfer agent is attacked to the end of a nucleotide chain assembly in a manner which is stable under conditions of deprotection of the polynucleotide, and growing a polymer from the initiator of from a site of the chain transfer agent via the reversible deactivation radical polymerization to form the polynucleotide composition.
    Type: Application
    Filed: April 17, 2014
    Publication date: March 17, 2016
    Inventors: SUBHA RANJAN DAS, SAADYAH AVERICK, SOURAV K. DEY, Krzysztof Matyjaszewski
  • POLYMER CONJUGATES FOR DELIVERY OF BIOLOGICALLY ACTIVE AGENTS
    Publication number: 20150275206
    Abstract: A delivery system for delivering oligonucleotides includes a conjugate includes a complexing agent including an oligonucleotide, a peptide nucleic acid or chimera thereof and a polymer covalently attached to the complexing agent. The complexing agent of the conjugate is adapted to complex a biologically active agent thereto after formation of the conjugate.
    Type: Application
    Filed: August 1, 2013
    Publication date: October 1, 2015
    Applicant: CARNEGIE MELLON UNIVERSITY
    Inventors: Subha Ranjan Das, Eduardo Paredes, Saadyah Averick, Krzysztof Matyjaszewski
  • Synthetic Lariat RNA for RNA Interference
    Publication number: 20140273216
    Abstract: Provided herein are compositions for the modification of gene expression by RNA interference using a microRNA (miRNA) guide strand precursor. Methods of making and using the miRNA guide strand precursor also are provided. The compositions bypass the Drosha-Exportin-Dicer pathway and are resistant to nucleases.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: Camegie Mellon University
    Inventors: Subha Ranjan Das, Eduardo Paredes