Patents by Inventor Subhabrata Bhattacharyya
Subhabrata Bhattacharyya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12134783Abstract: A tissue treatment apparatus and method for treating bone tissue has a controller, an enclosure, a reagent supply system, a draining configuration, and a gas relief valve is controlled by the controller. A bioactive agent may be applied through the reagent supply system. Optionally provided is a gas evacuation assembly, a gas supply unit, a thermal unit for heating or cooling reagents or gases, a sonication unit, any or each operated by the controller. The method provides for programming controller to effect a treatment procedure. In an embodiment of the present application the treatment procedure effects demineralization of the bone material.Type: GrantFiled: February 3, 2021Date of Patent: November 5, 2024Assignee: Warsaw Orthopedic, Inc.Inventors: Subhabrata Bhattacharyya, David R. Kaes, Daniel A. Shimko
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Patent number: 11903627Abstract: A device for mixing a bone material with a liquid is provided. The device comprises a chamber having a proximal end and a distal end, and the bone material disposed within the chamber, the bone material comprising a coherent mass of milled and lyophilized demineralized bone fibers; and a plunger having at least a portion slidably disposed within the proximal end of the chamber and configured to dispense the bone material mixed with liquid from the distal end of the chamber, when the plunger is in an extended position.Type: GrantFiled: May 20, 2020Date of Patent: February 20, 2024Assignee: Warsaw Orthopedic, Inc.Inventors: Kelly W. Schlachter, Daniel A. Shimko, Kerem N. Kalpakci, Erick Vasquez, David R. Kaes, Subhabrata Bhattacharyya
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Publication number: 20230293307Abstract: Computer implemented methods of producing a bone graft are provided. These methods include obtaining a 3-D image of an intended bone graft site; generating a 3-D digital model of the bone graft based on the 3-D image of the intended bone graft site, the 3-D digital model of the bone graft being configured to fit within a 3-D digital model of the intended bone graft site; storing the 3-D digital model on a database coupled to a processor, the processor having instructions for retrieving the stored 3-D digital model of the bone graft and for combining a carrier material with, in or on a bone material based on the stored 3-D digital model and for instructing a 3-D printer to produce the bone graft. A layered 3-D printed bone graft prepared by the computer implemented method is also provided.Type: ApplicationFiled: May 24, 2023Publication date: September 21, 2023Applicant: WARSAW ORTHOPEDIC INC.Inventors: SUBHABRATA BHATTACHARYYA, DAVID R. KAES, GUOBAO WEI, ANIL MISTRY
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Patent number: 11660196Abstract: Computer implemented methods of producing a bone graft are provided. These methods include obtaining a 3-D image of an intended bone graft site; generating a 3-D digital model of the bone graft based on the 3-D image of the intended bone graft site, the 3-D digital model of the bone graft being configured to fit within a 3-D digital model of the intended bone graft site; storing the 3-D digital model on a database coupled to a processor, the processor having instructions for retrieving the stored 3-D digital model of the bone graft and for combining a carrier material with, in or on a bone material based on the stored 3-D digital model and for instructing a 3-D printer to produce the bone graft. A layered 3-D printed bone graft prepared by the computer implemented method is also provided.Type: GrantFiled: April 21, 2017Date of Patent: May 30, 2023Assignee: Warsaw Orthopedic, Inc.Inventors: Subhabrata Bhattacharyya, David R. Kaes, Guobao Wei, Anil Mistry
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Publication number: 20230096765Abstract: Grafts modified with one or more bioactive substances are provided, as well as methods to make and use them. More particularly, the present invention relates to modified grafts having characteristics which facilitate tissue generation, repair, and reconstruction, and which are modified with bioactive substances, such as one or more proteins and minerals, whose bioactivity further facilitates tissue generation, repair, and reconstruction. Methods for producing the modified grafts include depositing the one or more bioactive substances onto, into, or both, a substrate material.Type: ApplicationFiled: September 28, 2022Publication date: March 30, 2023Inventors: Michael Vincent Basile, Subhabrata Bhattacharyya, Michele Christine McAllister
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Publication number: 20210180019Abstract: A tissue treatment apparatus and method for treating bone tissue has a controller, an enclosure, a reagent supply system, a draining configuration, and a gas relief valve is controlled by the controller. A bioactive agent may be applied through the reagent supply system. Optionally provided is a gas evacuation assembly, a gas supply unit, a thermal unit for heating or cooling reagents or gases, a sonication unit, any or each operated by the controller. The method provides for programming controller to effect a treatment procedure. In an embodiment of the present application the treatment procedure effects demineralization of the bone material.Type: ApplicationFiled: February 3, 2021Publication date: June 17, 2021Inventors: Subhabrata Bhattacharyya, David R. Kaes, Daniel A. Shimko
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Patent number: 10913930Abstract: A tissue treatment apparatus and method for treating bone tissue has a controller, an enclosure, a reagent supply system, a draining configuration, and a gas relief valve is controlled by the controller. A bioactive agent may be applied through the reagent supply system. Optionally provided is a gas evacuation assembly, a gas supply unit, a thermal unit for heating or cooling reagents or gases, a sonication unit, any or each operated by the controller. The method provides for programming controller to effect a treatment procedure. In an embodiment of the present application the treatment procedure effects demineralization of the bone material.Type: GrantFiled: August 9, 2016Date of Patent: February 9, 2021Assignee: Warsaw Orthopedic, Inc.Inventors: Subhabrata Bhattacharyya, David R. Kaes, Daniel A. Shimko
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Publication number: 20200275963Abstract: A device for mixing a bone material with a liquid is provided. The device comprises a chamber having a proximal end and a distal end, and the bone material disposed within the chamber, the bone material comprising a coherent mass of milled and lyophilized demineralized bone fibers; and a plunger having at least a portion slidably disposed within the proximal end of the chamber and configured to dispense the bone material mixed with liquid from the distal end of the chamber, when the plunger is in an extended position.Type: ApplicationFiled: May 20, 2020Publication date: September 3, 2020Inventors: Kelly W. Schlachter, Daniel A. Shimko, Kerem N. Kalpakci, Erick Vasquez, David R. Kaes, Subhabrata Bhattacharyya
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Patent number: 10660685Abstract: A device for mixing a bone material with a liquid is provided. The device comprises a chamber having a proximal end and a distal end, and the bone material disposed within the chamber, the bone material comprising a coherent mass of milled and lyophilized demineralized bone fibers; and a plunger having at least a portion slidably disposed within the proximal end of the chamber and configured to dispense the bone material mixed with liquid from the distal end of the chamber, when the plunger is in an extended position.Type: GrantFiled: November 13, 2015Date of Patent: May 26, 2020Assignee: Warsaw Orthopedic, Inc.Inventors: Kelly W. Schlachter, Daniel A. Shimko, Kerem N. Kalpakci, Erick Vasquez, David R. Kaes, Subhabrata Bhattacharyya
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Publication number: 20190336191Abstract: A bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of milled and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass. In some embodiments, a bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder on the coherent mass. In some embodiments, a method of implanting a bone material is provided, the method comprising contacting the bone material with a liquid, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass; molding the bone material into a shape to implant the bone material; and implanting the bone material at the target tissue site.Type: ApplicationFiled: July 18, 2019Publication date: November 7, 2019Applicant: Warsaw Orthopedic, Inc.Inventors: Kelly W. Schlachter, Daniel A. Shimko, Kerem Kalpakci, Erick Vasquez, David R. Kaes, Subhabrata Bhattacharyya
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Patent number: 10368930Abstract: A bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of milled and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass. In some embodiments, a bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder on the coherent mass. In some embodiments, a method of implanting a bone material is provided, the method comprising contacting the bone material with a liquid, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass; molding the bone material into a shape to implant the bone material; and implanting the bone material at the target tissue site.Type: GrantFiled: March 5, 2018Date of Patent: August 6, 2019Assignee: Warsaw Orthopedic,Inc.Inventors: Kelly W. Schlachter, Daniel A. Shimko, Kerem Kalpakci, Erick Vasquez, David R. Kaes, Subhabrata Bhattacharyya
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Patent number: 10194964Abstract: A bone material comprising a coherent mass of cartridge milled and demineralized bone fibers is provided, the coherent mass having no binder disposed in or on the coherent mass. In some embodiments, a bone material comprising a lyophilized coherent mass of cartridge milled and demineralized bone fibers is provided, the lyophilized coherent mass having no binder disposed in or on the coherent mass. In some embodiments, a method of making an implantable bone material is provided, the method comprising drying a coherent mass of cartridge milled and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass.Type: GrantFiled: November 13, 2015Date of Patent: February 5, 2019Assignee: Warsaw Orthopedic, Inc.Inventors: Kelly W. Schlachter, Daniel A. Shimko, Kerem N. Kalpakci, Erick Vasquez, David R. Kaes, Subhabrata Bhattacharyya
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Publication number: 20180303616Abstract: Computer implemented methods of producing a bone graft are provided. These methods include obtaining a 3-D image of an intended bone graft site; generating a 3-D digital model of the bone graft based on the 3-D image of the intended bone graft site, the 3-D digital model of the bone graft being configured to fit within a 3-D digital model of the intended bone graft site; storing the 3-D digital model on a database coupled to a processor, the processor having instructions for retrieving the stored 3-D digital model of the bone graft and for combining a carrier material with, in or on a bone material based on the stored 3-D digital model and for instructing a 3-D printer to produce the bone graft. A layered 3-D printed bone graft prepared by the computer implemented method is also provided.Type: ApplicationFiled: April 21, 2017Publication date: October 25, 2018Inventors: Subhabrata Bhattacharyya, David R. Kaes, Guobao Wei, Anil Mistry
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Patent number: 10080661Abstract: An osteoimplant composite comprising a plurality of particles of an inorganic material, a bone substitute material, a bone-derived material, or any combination thereof; and a polymer material with which the particles are combined. The composite is either naturally moldable or flowable, or it can be made moldable or settable. After implantation, the composite may be set to provide mechanical strength to the implant. The inventive composite have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength required for most orthopedic applications. The invention also provides methods of using and preparing the moldable and flowable composites.Type: GrantFiled: May 9, 2016Date of Patent: September 25, 2018Assignee: Warsaw Orthopedic, Inc.Inventors: Deger C. Tunc, John Winterbottom, David R. Kaes, Todd Boyce, David Knaack, James Russell, Subhabrata Bhattacharyya
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Publication number: 20180193077Abstract: A bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of milled and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass. In some embodiments, a bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder on the coherent mass. In some embodiments, a method of implanting a bone material is provided, the method comprising contacting the bone material with a liquid, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass; molding the bone material into a shape to implant the bone material; and implanting the bone material at the target tissue site.Type: ApplicationFiled: March 5, 2018Publication date: July 12, 2018Inventors: Kelly W. Schlachter, Daniel A. Shimko, Kerem Kalpakci, Erick Vasquez, David R. Kaes, Subhabrata Bhattacharyya
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Patent number: 10006705Abstract: Methods for treating bulk bone tissue are provided. The methods comprise contacting bulk bone tissue or frozen bulk bone tissue with an effective amount of a supercritical fluid so as to dry the bulk bone tissue. In various embodiments, the supercritical fluid destroys contaminants such that the frozen bulk bone tissue is 99.9% substantially pure. In various embodiments, contaminants removed from the frozen bulk bone tissue include lipids, viruses, bacteria, pyrogens, prions, micro-organisms and/or pathogens. In some embodiments, the supercritical fluid causes a 3 log reduction of bacteria within the frozen bulk bone tissue.Type: GrantFiled: February 9, 2015Date of Patent: June 26, 2018Assignee: Warsaw Orthopedic, Inc.Inventors: Guobao Wei, David R. Kaes, Susan J. Drapeau, Subhabrata Bhattacharyya
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Patent number: 9913676Abstract: A bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of milled and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass. In some embodiments, a bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder on the coherent mass. In some embodiments, a method of implanting a bone material is provided, the method comprising contacting the bone material with a liquid, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass; molding the bone material into a shape to implant the bone material; and implanting the bone material at the target tissue site.Type: GrantFiled: November 13, 2015Date of Patent: March 13, 2018Assignee: Warsaw Orthopedic, Inc.Inventors: Kelly W. Schlachter, Daniel A. Shimko, Kerem N. Kalpakci, Erick Vasquez, David R. Kaes, Subhabrata Bhattacharyya
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Publication number: 20180044638Abstract: A tissue treatment apparatus and method for treating bone tissue has a controller, an enclosure, a reagent supply system, a draining configuration, and a gas relief valve is controlled by the controller. A bioactive agent may be applied through the reagent supply system. Optionally provided is a gas evacuation assembly, a gas supply unit, a thermal unit for heating or cooling reagents or gases, a sonication unit, any or each operated by the controller. The method provides for programming controller to effect a treatment procedure. In an embodiment of the present application the treatment procedure effects demineralization of the bone material.Type: ApplicationFiled: August 9, 2016Publication date: February 15, 2018Inventors: Subhabrata Bhattacharyya, David R. Kaes, Daniel A. Shimko
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Publication number: 20160250025Abstract: An osteoimplant composite comprising a plurality of particles of an inorganic material, a bone substitute material, a bone-derived material, or any combination thereof; and a polymer material with which the particles are combined. The composite is either naturally moldable or flowable, or it can be made moldable or settable. After implantation, the composite may be set to provide mechanical strength to the implant. The inventive composite have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength required for most orthopedic applications. The invention also provides methods of using and preparing the moldable and flowable composites.Type: ApplicationFiled: May 9, 2016Publication date: September 1, 2016Inventors: Deger C. Tunc, John Winterbottom, David R. Kaes, Todd Boyce, David Knaack, James Russell, Subhabrata Bhattacharyya
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Publication number: 20160231056Abstract: Methods for treating bulk bone tissue are provided. The methods comprise contacting bulk bone tissue or frozen bulk bone tissue with an effective amount of a supercritical fluid so as to dry the bulk bone tissue. In various embodiments, the supercritical fluid destroys contaminants such that the frozen bulk bone tissue is 99.9% substantially pure. In various embodiments, contaminants removed from the frozen bulk bone tissue include lipids, viruses, bacteria, pyrogens, prions, micro-organisms and/or pathogens. In some embodiments, the supercritical fluid causes a 3 log reduction of bacteria within the frozen bulk bone tissue.Type: ApplicationFiled: February 9, 2015Publication date: August 11, 2016Inventors: Guobao Wei, David R. Kaes, Susan J. Drapeau, Subhabrata Bhattacharyya