Abstract: Systems and methods for computing feature contribution and providing hum-interpretable reason codes for a Support Vector Machine (SVM) model are disclosed, A system computes, for each data point from amongst plurality of data points indicative of plurality of features, a feature contribution of each one of the plurality of features for a SVM model used for at least one of classification decision and a regression analysis. Further, the system provides human interpretable reason code for the interpretation corresponding to at least one of classification decision and the regression analysis from the SVM model. The system outputs to the user, a feature contribution output, and the human interpretable reason codes output. The feature contribution output and the human interpretable reason codes output are indicative of an acceptable decision to be taken by the user based on the classification decision and the regression analysis received from the SVM model.

Abstract: Disclosed are various synthetic methods to prepare structural analogs of largazole and derivatives thereof. One structural analog is an amide isostere of largazole. Another structural analog replaces the thiazole ring of largazole with a pyridine moiety or an oxazole moiety.