Patents by Inventor Subhadra Rukmini Jayaraman

Subhadra Rukmini Jayaraman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for separation of prokaryotic DNA from eukaryotic DNA in a whole blood sample
    Patent number: 10358640
    Abstract: A process for separating prokaryotic DNA from eukaryotic DNA in a whole blood sample infected by pathogen is provided. The process includes extracting prokaryotic and eukaryotic DNA from the whole blood sample, contacting the prokaryotic DNA in the whole blood sample with a motif that specifically binds to the prokaryotic DNA, and generating a bound pair. The process also includes separating the bound pair. The whole blood sample is transfected with bacteriophages genetically modified to contain a defined DNA sequence having a selectable marker DNA. The DNA sequence integrates into the prokaryotic DNA, and the motif is an oligonucleotide specific to the defined DNA sequence in the engineered bacteriophages.
    Type: Grant
    Filed: August 18, 2015
    Date of Patent: July 23, 2019
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Subhadra Rukmini Jayaraman, Ramya Vutukuru
  • PROCESS FOR SEPARATION OF PROKARYOTIC DNA FROM EUKARYOTIC DNA IN A WHOLE BLOOD SAMPLE
    Publication number: 20190085316
    Abstract: A process for separating prokaryotic DNA from eukaryotic DNA in a whole blood sample infected by pathogen is provided. The process includes extracting prokaryotic and eukaryotic DNA from the whole blood sample, contacting the prokaryotic DNA in the whole blood sample with a motif that specifically binds to the prokaryotic DNA, and generating a bound pair. The process also includes separating the bound pair. The whole blood sample is transfected with bacteriophages genetically modified to contain a defined DNA sequence having a selectable marker DNA. The DNA sequence integrates into the prokaryotic DNA, and the motif is an oligonucleotide specific to the defined DNA sequence in the engineered bacteriophages.
    Type: Application
    Filed: August 18, 2015
    Publication date: March 21, 2019
    Inventors: Subhadra Rukmini Jayaraman, Ramya Vutukuru