Patents by Inventor Subhashini Srinivasan
Subhashini Srinivasan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8575103Abstract: Permeable Switch Region I and II peptides in the range of 9 to 25 amino acid residues in length are provided for specifically inhibiting signaling through G? subunits. In addition, compositions and methods for inhibiting platelet aggregation and ?11b?3 integrin activation using the Switch Region I and II peptides are provided.Type: GrantFiled: March 21, 2012Date of Patent: November 5, 2013Assignee: The Board of Trustees of the University of IllinoisInventors: Guy Le Breton, Jin-Sheng Huang, Subhashini Srinivasan, Fadi T. Khasawneh
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Patent number: 8407604Abstract: A method, computer program product, and computing system for defining text to be included within a first text message. One or more tags are assigned to the first text message. The one or more tags are chosen from a plurality of available tags. The first text message, including the text and the one or more tags, is transmitted to one or more recipients.Type: GrantFiled: December 30, 2008Date of Patent: March 26, 2013Assignee: International Business Machines CorporationInventors: Kevin Solie, Subhashini Srinivasan
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Publication number: 20130040886Abstract: The present invention comprises peptide compositions and methods for specifically inhibiting signaling through G? subunits.Type: ApplicationFiled: March 21, 2012Publication date: February 14, 2013Applicant: The Board of Trustees of the University of IllinoisInventors: Guy LeBreton, Jin-Sheng Huang, Subhashini Srinivasan, Fadi T. Khasawneh
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Publication number: 20100169793Abstract: A method, computer program product, and computing system for defining text to be included within a first text message. One or more tags are assigned to the first text message. The one or more tags are chosen from a plurality of available tags. The first text message, including the text and the one or more tags, is transmitted to one or more recipients.Type: ApplicationFiled: December 30, 2008Publication date: July 1, 2010Inventors: Kevin Solie, Subhashini Srinivasan
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Publication number: 20030091564Abstract: There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding region of a CD40 receptor.Type: ApplicationFiled: August 2, 1999Publication date: May 15, 2003Inventors: RICHARD J. ARMITAGE, WILLIAM C. FANSLOW, MELANIE K. SPRIGGS, SUBHASHINI SRINIVASAN, MARYLOU G. GIBSON
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Patent number: 6410711Abstract: There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding region of a CD40 receptor.Type: GrantFiled: September 20, 1999Date of Patent: June 25, 2002Assignee: Immunex CorporationInventors: Richard J. Armitage, William C. Fanslow, Melanie K. Spriggs, Subhashini Srinivasan, Marylou G. Gibson, Arvia E. Morris, Jeffrey T. McGrew
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Patent number: 6391637Abstract: There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding region of a CD40 receptor. Also disclosed are methods of simulating hybridoma cells to increase monoclonal antibody production by administering a CD40 ligand polypeptide that stimulates B cell proliferation.Type: GrantFiled: December 19, 1996Date of Patent: May 21, 2002Inventors: Richard J. Armitage, William C. Fanslow, Melanie K. Spriggs, Subhashini Srinivasan, Marylou G. Gibson
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Patent number: 6290972Abstract: There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding region of a CD40 receptor.Type: GrantFiled: December 19, 1996Date of Patent: September 18, 2001Assignee: Immunex CorporationInventors: Richard J. Armitage, William C. Fanslow, Melanie K. Spriggs, Subhashini Srinivasan, Marylou G. Gibson
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Patent number: 6264951Abstract: There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding region of a CD40 receptor. Also disclosed are methods of inhibiting undesirable immune responses, preventing T cell interaction with B cells by blocking CD40L binding to CD40 sites on B cells and other target cells.Type: GrantFiled: December 19, 1996Date of Patent: July 24, 2001Assignee: Immunex CorporationInventors: Richard J. Armitage, William C. Fanslow, Melanie K. Spriggs, Subhashini Srinivasan, Marylou G. Gibson
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Patent number: 5981724Abstract: There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding region of a CD40 receptor.Type: GrantFiled: June 7, 1995Date of Patent: November 9, 1999Assignee: Immunex CorporationInventors: Richard J. Armitage, William C. Fanslow, Melanie K. Spriggs, Subhashini Srinivasan, Marylou G. Gibson, Arvia E. Morris, Jeffrey T. McGrew
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Patent number: 5962406Abstract: There is disclosed a polypeptide (CD40-L) and DNA sequences, vectors and transformed host cells useful in providing CD40-L polypeptides. More particularly, this invention provides isolated human and murine CD40-L polypeptides that bind to the extracellular binding region of a CD40 receptor.Type: GrantFiled: June 7, 1995Date of Patent: October 5, 1999Assignee: Immunex CorporationInventors: Richard J. Armitage, William C. Fanslow, Melanie K. Spriggs, Subhashini Srinivasan, Marylou G. Gibson, Arvia E. Morris, Jeffrey T. McGrew
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Patent number: 5884230Abstract: A method in a computer system for modeling a three-dimensional structure of a model protein is provided. In one embodiment, the modeling is based upon a three-dimensional structure of a template protein and an amino acid sequence alignment of the model protein and the template protein. For each amino acid in the model protein, when the template protein has an amino acid aligned with the amino acid of the model protein, the position of the backbone atom of the amino acid of the model protein is established based on the position of a topologically equivalent backbone atom in the aligned amino acid of the template protein. In another embodiment, the modeling of a variable region of the model protein is based on a collection of .psi. and .phi. angle values for amino acid pairs in a family of proteins. In a further embodiment, these .psi. and .phi.Type: GrantFiled: June 14, 1996Date of Patent: March 16, 1999Assignee: Immunex CorporationInventors: Subhashini Srinivasan, Padmanaban Sudarsanam
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Patent number: 5716805Abstract: There is disclosed a method of preparing a soluble mammalian protein by culturing a host cell transformed or transfected with an expression vector encoding a fusion protein comprising a zipper domain and a heterologous mammalian protein.Type: GrantFiled: May 18, 1995Date of Patent: February 10, 1998Assignee: Immunex CorporationInventors: Subhashini Srinivasan, Melanie K. Spriggs
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Patent number: 5557535Abstract: A method in a computer system for modeling a three-dimensional structure of a model protein is provided. In a preferred embodiment, the modeling is based upon a three-dimensional structure of a template protein and an amino acid sequence alignment of the model protein and the template protein. The proteins comprise a plurality of amino acids having backbone atoms and side chain atoms. For each amino acid in the model protein, when the template protein has an amino acid aligned with the amino acid of the model protein, the position of each backbone atom of the amino acid of the model protein is established based on the position of a topologically equivalent backbone atom in the aligned amino acid of the template protein. The inter-atomic distance constraints for each pair of atoms with an established position is generated. Finally, the position of each atom in the model protein is set so that the inter-atomic distances are in accordance with the constraints.Type: GrantFiled: April 28, 1994Date of Patent: September 17, 1996Assignee: Immunex CorporationInventors: Subhashini Srinivasan, Padmanaban Sudarsanam
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Patent number: 5453937Abstract: A method in a computer system for modeling a three-dimensional structure of a model protein is provided. In a preferred embodiment, the modeling is based upon a three-dimensional structure of a template protein and an amino acid sequence alignment of the model protein and the template protein. The proteins comprise a plurality of amino acids having backbone atoms and side chain atoms. For each amino acid in the model protein, when the template protein has an amino acid aligned with the amino acid of the model protein, the position of each backbone atom of the amino acid of the model protein is established based on the position of a topologically equivalent backbone atom in the aligned amino acid of the template protein. The inter-atomic distance constraints for each pair of atoms with an established position is generated. Finally, the position of each atom in the model protein is set so that the inter-atomic distances are in accordance with the constraints.Type: GrantFiled: April 28, 1993Date of Patent: September 26, 1995Assignee: Immunex CorporationInventors: Subhashini Srinivasan, Padmanaban Sudarsanam