Patents by Inventor Subo Liao

Subo Liao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PEPTIDES FOR TREATMENT OF MEDICAL DISORDERS
    Publication number: 20220354923
    Abstract: The present invention provides compounds which are selective kappa-opioid receptor agonist, method of preparation of these compounds, compositions that comprise these compounds, and methods for treating kappa-opiod receptor agonist related medical disorders.
    Type: Application
    Filed: July 11, 2022
    Publication date: November 10, 2022
    Inventors: Subo Liao, Jun Yang, Jinliang Lv, Zongquan Liao, Hao Zhou, Jueyuan Gao, Tianpeng Xie, Quanli Yang, Yao He, Dali Liang, Rong Liu
  • Peptides for treatment of medical disorders
    Patent number: 11492374
    Abstract: The present invention provides compounds which are selective kappa-opioid receptor agonist, method of preparation of these compounds, compositions that comprise these compounds, and methods for treating kappa-opiod receptor agonist related medical disorders.
    Type: Grant
    Filed: June 25, 2020
    Date of Patent: November 8, 2022
    Assignee: Humanwell Pharmaceutical US
    Inventors: Subo Liao, Jun Yang, Jinliang Lv, Zongquan Liao, Hao Zhou, Jueyuan Gao, Tianpeng Xie, Quanli Yang
  • NOVEL MORPHINANS USEFUL FOR TREATING MEDICAL DISORDERS
    Publication number: 20220089605
    Abstract: The present invention related to novel morphinans, compositions comprising the novel morphinans, and their uses as agonists of the kappa opioid receptor.
    Type: Application
    Filed: November 30, 2021
    Publication date: March 24, 2022
    Inventors: Subo Liao, Jun Yang, Jie Li, Wentao Du, Lie Li, Jinliang Lv, Zongquan Liao, Hao Zhou, Tianpeng Xie, Jianbo Yu
  • Morphinans useful for treating medical disorders
    Patent number: 11214577
    Abstract: The present invention related to novel morphinans, compositions comprising the novel morphinans, and their uses as agonists of the kappa opioid receptor.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: January 4, 2022
    Assignee: Humanwell Pharmaceutical US
    Inventors: Subo Liao, Jun Yang, Jie Li, Wentao Du, Lie Li, Jinliang Lv, Zongquan Liao, Hao Zhou, Tianpeng Xie, Jianbo Yu
  • PEPTIDES FOR TREATMENT OF MEDICAL DISORDERS
    Publication number: 20210403505
    Abstract: The present invention provides compounds which are selective kappa-opioid receptor agonist, method of preparation of these compounds, compositions that comprise these compounds, and methods for treating kappa-opiod receptor agonist related medical disorders
    Type: Application
    Filed: June 25, 2020
    Publication date: December 30, 2021
    Inventors: Subo Liao, Jun Yang, Jinliang Lv, Zongquan Liao, Hao Zhou, Jueyuan Gao, Tianpeng Xie, Quanli Yang
  • KAPPA OPIOID RECEPTOR PEPTIDE AMIDE AGONISTS
    Publication number: 20210040150
    Abstract: The present invention provides kappa opioid receptor peptide agonists, methods for preparing these compounds, compositions comprising these kappa opioid receptor peptide agonists, and methods of using the kappa opioid receptor peptide agonists to treat pain or other conditions.
    Type: Application
    Filed: August 7, 2020
    Publication date: February 11, 2021
    Inventors: Subo Liao, Jun Yang, Jinliang Lv, Zongquan Liao, Hao Zhou, Jueyuan Gao, Tianpeng Xie, Quanli Yang, Lei Wang, Zejian Ding
  • NOVEL MORPHINANS USEFUL FOR TREATING MEDICAL DISORDERS
    Publication number: 20200308185
    Abstract: The present invention related to novel morphinans, compositions comprising the novel morphinans, and their uses as agonists of the kappa opioid receptor.
    Type: Application
    Filed: March 30, 2020
    Publication date: October 1, 2020
    Inventors: Subo Liao, Jun Yang, Jie Li, Wentao Du, Lie Li, Jinliang Lv, Zongquan Liao, Hao Zhou, Tianpeng Xie, Jianbo Yu
  • Two-step process for preparing 3-substituted phenylalkylamines
    Patent number: 9914695
    Abstract: Processes for preparing 3-substituted phenylalkylamines comprising reacting a phenyl boronic compound with an ?-? unsaturated carbonyl-containing compound via an asymmetric 1,4-addition reaction, followed by reductive alkylation. The processes may be useful in the synthesis of tapentadol.
    Type: Grant
    Filed: July 6, 2016
    Date of Patent: March 13, 2018
    Assignee: Mallinckrodt LLC
    Inventors: Doug Teramura, Subo Liao
  • Process for preparing substituted phenylalkanes
    Patent number: 9556108
    Abstract: The invention provides methods for preparing substituted phenylalkanes. In particular, the processes comprise reacting a phenyl boronic compound with an ?-? unsaturated carbonyl-containing compound via an asymmetric 1,4-addition reaction. The processes may be useful in the synthesis of tapentadol.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: January 31, 2017
    Assignee: Mallinckrodt LLC
    Inventors: Subo Liao, Joseph McClurg, Bobby Trawick
  • TWO-STEP PROCESS FOR PREPARING 3-SUBSTITUTED PHENYLALKYLAMINES
    Publication number: 20170008832
    Abstract: Processes for preparing 3-substituted phenylalkylamines comprising reacting a phenyl boronic compound with an ?-? unsaturated carbonyl-containing compound via an asymmetric 1,4-addition reaction, followed by reductive alkylation. The processes may be useful in the synthesis of tapentadol.
    Type: Application
    Filed: July 6, 2016
    Publication date: January 12, 2017
    Inventors: Doug Teramura, Subo Liao
  • PROCESS FOR PREPARING SUBSTITUTED PHENYLALKANES
    Publication number: 20160009635
    Abstract: The invention provides methods for preparing substituted phenylalkanes. In particular, the processes comprise reacting a phenyl boronic compound with an ?-? unsaturated carbonyl-containing compound via an asymmetric 1,4-addition reaction. The processes may be useful in the synthesis of tapentadol.
    Type: Application
    Filed: July 10, 2015
    Publication date: January 14, 2016
    Inventors: Subo Liao, Joseph McClurg, Bobby Trawick
  • Preparation of normorphinans
    Patent number: 9127009
    Abstract: The present invention provides processes for preparing normorphinans from N-substituted morphinans. In particular, the invention provides methods for removing the N-substituent from the N-substituted morphinan to from a normorphinan carbamate, and then removing the carbamate functionality from the normorphinan carbamate to form the normorphinan.
    Type: Grant
    Filed: November 18, 2014
    Date of Patent: September 8, 2015
    Assignee: Mallinckrodt LLC
    Inventors: John Brandt, Subo Liao, Edmund C. Hudson, Esa T. Jarvi, Peter X. Wang, Michael Schaefer
  • PREPARATION OF NORMORPHINANS
    Publication number: 20150141649
    Abstract: The present invention provides processes for preparing normorphinans from N-substituted morphinans. In particular, the invention provides methods for removing the N-substituent from the N-substituted morphinan to from a normorphinan carbamate, and then removing the carbamate functionality from the normorphinan carbamate to form the normorphinan.
    Type: Application
    Filed: November 18, 2014
    Publication date: May 21, 2015
    Inventors: John Brandt, Subo Liao, Edmund C. Hudson, Esa T. Jarvi, Peter X. Wang, Michael Schaefer
  • Tandem process for preparing N-alkyl morphinans
    Patent number: 8703949
    Abstract: The present invention provides processes for the preparation of N-alkyl morphinans without the isolation of nor-morphinan intermediates. In particular, the invention provides tandem hydrolysis/alkylation reactions for the synthesis of N-alkyl morphinans.
    Type: Grant
    Filed: August 3, 2011
    Date of Patent: April 22, 2014
    Assignee: Mallinckrodt LLC
    Inventors: Subo Liao, Peter X. Wang, David W. Berberich, Douglas C. Miller
  • N-demethylation of 6-keto morphinans
    Patent number: 8624030
    Abstract: The present invention provides processes for the demethylation of an N-methyl morphinan comprising a ketone functional group. In particular, the invention provides methods for the protection of the ketone functional group such that impurities are not generated during the demethylation of the N-methyl morphinan.
    Type: Grant
    Filed: August 3, 2011
    Date of Patent: January 7, 2014
    Assignee: Mallinckrodt LLC
    Inventors: Peter X. Wang, Tao Jiang, David W. Berberich, Subo Liao
  • Sinomenine derivatives and processes for their synthesis
    Patent number: 8614224
    Abstract: The invention generally provides processes and intermediate compounds useful for the production of sinomenine derivatives. In particular, the process may encompass synthetic routes for the production of (+)-sinomenine derivatives and their intermediates.
    Type: Grant
    Filed: January 18, 2012
    Date of Patent: December 24, 2013
    Assignee: Mallinckrodt LLC
    Inventors: Peter X. Wang, Tao Jiang, Gary L. Cantrell, David W. Berberich, Bobby N. Trawick, Subo Liao, John Brandt
  • (+)-morphinanium N-oxides and processes for their production
    Patent number: 8563727
    Abstract: The present invention provides (+)-morphinanium N-oxide compounds or pharmaceutically acceptable salts thereof. The invention also provides processes for producing (+)-morphinanium N-oxides or pharmaceutically acceptable salts thereof from the corresponding tertiary N-substituted (+)-morphinan compound or pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: February 23, 2010
    Date of Patent: October 22, 2013
    Assignee: Mallinckrodt LLC
    Inventors: Gary L. Cantrell, Peter X. Wang, Bobby N. Trawick, Christopher W. Grote, David W. Berberich, Hang Sun, Subo Liao
  • Sinomenine derivatives and processes for their synthesis
    Patent number: 8461337
    Abstract: The invention generally provides processes and intermediate compounds useful for the production of sinomenine derivatives. In particular, the process may encompass synthetic routes for the production of (+)-sinomenine derivatives and their intermediates.
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: June 11, 2013
    Assignee: Mallinckrodt LLC
    Inventors: Peter X. Wang, Tao Jiang, Gary L. Cantrell, David W. Berberich, Bobby N. Trawick, Subo Liao, John Brandt
  • Process for preparing hydrocodone using a super acid
    Patent number: 8367827
    Abstract: The present disclosure generally relates to a process for converting a fused, tricyclic compound to a fused, tetracyclic compound that includes a furan ring therein. More particularly, the present disclosure related to a process for preparing a hydrocodone compound, or a compound structurally related thereto, and in particular (+)-hydrocodone, by subjecting a structurally corresponding sinomenine starting compound to a super acid-assisted furan ring closure reaction.
    Type: Grant
    Filed: November 30, 2009
    Date of Patent: February 5, 2013
    Assignee: Mallinckrodt LLC
    Inventors: Peter X. Wang, Tao Jiang, Subo Liao, Erin Moore
  • Process and compounds for the production of (+)opiates
    Patent number: 8252808
    Abstract: The invention generally provides processes and intermediate compounds useful for the production of (+)-opiates. Non-limiting examples of (+) opiates that may be derived from one or more compounds of the invention include (+)-noroxymorphone, (+)-naltrexone, (+)-naloxone, (+)-N-cyclopropylmethylnorhydrocodone, (+)-N-cycloproylmethylnorhydromorphone, (+)-N-allylnorhydrocodone, (+)-N-allylnorhydromorphone, (+)-noroxycodone, (+)-naltrexol, (+)-naloxol, and (+)-3-O-methyl-naltrexone.
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: August 28, 2012
    Assignee: Mallinckrodt LLC
    Inventors: Peter X. Wang, Tao Jiang, Gary L. Cantrell, David W. Berberich, Bobby N. Trawick, Todd Osiek, Subo Liao, Frank W. Moser, Joseph P. McClurg