Abstract: Medical systems and related methods useful for the retrieval of multiple tissue samples are described. The system may include a sleeve defining a lumen and an aperture proximate a distal end of the sleeve, an inner guide slidable along the lumen of the sleeve and rotatable relative to the sleeve via a handle at a proximal end of the inner guide. A distal end of the inner guide may have a closed atraumatic tip. The inner guide may define at least two cavities each having a shape corresponding to the aperture of the sleeve. The inner guide may be rotatable relative to the sleeve to align one of the at least two cavities with the sleeve to retrieve a tissue sample by proximal or distal movement of the inner guide relative to the sleeve.

Abstract: Medical devices and related methods are described. The medical device may include a handle and a shaft extending distally from the handle. The shaft may have a longitudinal axis and a lumen that terminates at a distal end of the shaft, the distal end including an imaging device. A distal end portion of the shaft may include a transparent or translucent material, and may include a light source, a mirror, and/or a reflector. The light source may be proximal to the distal end of the shaft. The mirror may be longitudinally between the light source and the reflector. The reflector may be proximal to the imaging device.

Abstract: A medical device that includes a body and an arm extending from the body and configured to receive a first device such that the first device is suspended relative to the body. Translation of the arm relative to the body is configured to move the first device relative to the body. The medical device includes a receiver extending from the body and configured to receive a second device such that the second device is suspended relative to the body.

Abstract: A medical device is disclosed herein. The medical device including a disposable portion. The disposable portion including a sheath and a wire disposed within a lumen of the sheath. The medical device further including a handle. The handle including a main body with a slot and a releasably engageable moveable body. The moveable body is formed by a first component and a second component. The first component and the second component are releasably engageable with both the slot and a proximal portion of the disposable portion. Movement of the moveable body is configured to move the wire.

Abstract: A medical device may comprise a proximal component. The proximal component may comprise a handle with a coupling portion. The coupling portion is configured to releasably couple to a distal joint of a distal component of the medical device. A proximal wire may extend distally from the handle. The distal end of the proximal wire may include a connector that may be configured to releasably connect to a distal wire of the distal component of the medical device.

Abstract: A medical device that includes a handle including a first body and a second body that are movable relative to one another, and an actuator including a first housing movably coupled to the first body and a second housing movably coupled to the second body. The medical device is configured to move between an open configuration in which the first body is at least partially decoupled from the second body and the first housing is at least partially decoupled from the second housing, and a closed configuration in which the first body is coupled to the second body and the first housing is coupled to the second housing.

Abstract: A medical device includes a handle with a proximal arm and a distal arm. The proximal arm and the distal arm are pivotable via a joint. The medical device also includes a tube coupled to the distal arm and a drive wire. A distal portion of the drive wire includes an expandable end effector. A portion of the drive wire is positioned within the tube, and a different portion of the drive wire extends proximally of the distal arm and is coupled to the proximal arm.

Abstract: A medical device includes a handle, a shaft extending from the handle, and an articulation member integral with or attached to a distal end of the shaft. The articulation member includes a first portion coupled to a second portion, the second portion is receivable in a slot defined by the first portion, and the handle is coupled to each of the first portion and the second portion and to articulate the first portion independently of articulating the second portion.

Abstract: A medical device, for example a delivery catheter, may include a handle portion, a shaft portion extending distally from the handle portion, a deployment mechanism, and an actuation member positioned on the handle portion. The shaft portion may include a working channel and a distal tip portion having a payload chamber configured to receive a payload, such as a bio-absorbable foam. The distal tip portion may be operatively connected to the working channel. The deployment mechanism may be positioned in the working channel, and may be operable to deploy the payload out from the distal tip portion. The actuation member may be actuatable to operate the deployment mechanism.

Abstract: A medical device may include a handle including a fixed body and a movable body. The movable body may be movable relative to the fixed body. The medical device may include a shaft extending from the fixed body and an end effector at a distal end of the shaft. Rotation of the movable body relative to the fixed body may permit rotation of the end effector relative to the shaft, and rotation of the movable body with rotation of the fixed body may permit rotation of the end effector with the shaft. Deflection of the movable body relative to the fixed body may permit deflection of the end effector relative to the fixed body.

Abstract: A medical device that includes a handle including a plurality of actuators. The handle defines a longitudinal axis extending through a distal end of the handle. The device includes a shaft extending from the handle and an end effector at a distal end of the shaft. A first actuator of the plurality of actuators is configured to actuate the end effector in response to translation of the first actuator relative to the handle along an axis parallel to the longitudinal axis. A second actuator of the plurality of actuators is configured to deflect the end effector relative to the shaft in response to pivoting the second actuator about an axis transverse to the longitudinal axis. A third actuator of the plurality of actuators is configured to rotate the end effector relative to the shaft in response to rotation of the third actuator relative to the handle about the longitudinal axis.

Abstract: A system for treating tissue including a clip assembly including a pair of clip arms, a proximal end of each of the clip arms slidably received within a channel of a capsule and moveable between a tissue receiving configuration and a tissue clipping configuration. The system also including an applicator releasably coupleable to the clip assembly, the applicator including a control member connectable to the proximal end of each of the clip arms and a locking sleeve coupleable to a proximal end of the capsule via a deflectable tab including an engaging structure configured to engage a corresponding engaging structure at the proximal end of the capsule and a releasing structure proximal of the engaging structure, the releasing structure engagable with a portion of the control member to deflect the deflectable member and disengage the engaging structure of the locking sleeve from the corresponding engaging structure of the capsule.

Abstract: A medical device that includes a handle, a sheath extending from the handle, and a tool within the sheath and movable relative to the sheath. The handle includes an inner body and an outer body disposed over the inner body. The outer body is movable relative to the inner body. The handle includes a first actuator secured to the tool. The first actuator has an actuated state permitting movement of the tool relative to the sheath in response to moving the outer body relative to the inner body. The handle includes a second actuator secured to the sheath. The second actuator has an actuated state permitting movement of the sheath relative to the tool in response to moving the second actuator relative to the outer body. An unactuated state of the first actuator and an unactuated state of the second actuator prevents movement of the tool relative to the sheath.

Abstract: A medical device includes a handle with a proximal arm and a distal arm. The proximal arm and the distal arm are pivotable via a joint. The medical device also includes a tube coupled to the distal arm and a drive wire. A distal portion of the drive wire includes an expandable end effector. A portion of the drive wire is positioned within the tube, and a different portion of the drive wire extends proximally of the distal arm and is coupled to the proximal arm.

Abstract: A medical device comprising, a handle body, a flexible shaft coupled to a distal end of the handle body, a distal tip coupled to a distal end of the shaft and including a movable element, and an actuator coupled to the handle body and configured, upon actuation, to move the movable element, wherein the actuator includes a first contact element having outer contact surfaces each configured for contact by a finger of a user, each of the outer contact surfaces being at least one of angled and recessed relative to the other outer contact surfaces to provide a plurality of positions of contact between the finger and the actuator.

Abstract: A linkage assembly for a medical device, may comprise a control lever, a rotatable member rotatable about a first axis, and a plurality of linkages including a first linkage, a second linkage, and a third linkage. The first linkage may include a first end coupled to the rotatable member and a second, opposite end coupled to a first end of the second linkage. The second linkage may include the first end coupled to the second end of the first linkage and a second, opposite end coupled to a first end of the third linkage, wherein the second linkage may be rotatable about a second axis parallel with the first axis. A second end of the third linkage may translate along a third axis, and the second axis is offset from the third axis.

Abstract: The system can include a multi-lumen chamber can removably connected to and in fluid communication with a proximal end of a mixing lumen and include a first lumen aligned with a second lumen. The first lumen can be configured to include a first constituent in a first cavity. A first plunger can be internally positioned within the first lumen to control flow of the first constituent from the first cavity into the mixing lumen. The first cavity can terminate in a first port in fluid communication with the proximal end of the mixing lumen. The second lumen can be configured to include a second constituent. A second plunger can be internally positioned within the second lumen. The second lumen can terminate in a second port adjacent the first port and in fluid communication with the proximal end of the mixing lumen.

Abstract: A system for producing a mixture to deliver to a treatment site. A multi-lumen chamber can be connected to a proximal end of a mixing lumen and include a first lumen aligned and adjacent a second lumen. The first lumen can be configured to include a first constituent in a proximal portion of the first lumen and a second constituent in a distal portion of the first lumen. A first plunger can be internally positioned within the first lumen to distally move the first constituent into the distal portion to mix with the second constituent in a first state to form a first mixture. The first lumen can terminate in a first port. The second lumen is configured to include a third constituent. A second plunger is internally positioned within the second lumen to distally move the third constituent and the first mixture.

Abstract: A system is disclosed for producing a mixture to deliver to a treatment site. The system can include a mixing lumen attachable to a proximal end of a delivery system. A multi-lumen chamber can be connected to a proximal end of the mixing lumen and include a first lumen aligned and adjacent a second lumen. The first lumen can receive a first constituent in a first state. The first lumen can include a first plunger to move the first constituent from the first lumen to the mixing lumen. The second lumen can include a second constituent and a second plunger to distally move the second constituent and the first constituent in a second state. Distally moving the second plunger causes the first constituent and the second constituent to be mixed together within the mixing lumen to form the mixture.

Abstract: A system includes a connector with a central lumen. A multi-lumen chamber is removably connected to and in fluid communication with a proximal end of the central lumen. The multi-lumen chamber includes a first lumen aligned and adjacent a second lumen. The first lumen includes a first fluid in a proximal portion of the first lumen and a hydrophilic polymer in a distal portion of the first lumen, a first plunger rod within the first lumen to control flow of the first fluid into the distal portion to mix with the hydrophilic polymer in a first state to form a first mixture, and a first port. The second lumen includes a second fluid, a second plunger rod within the second lumen to distally move the second fluid and the first mixture in a second state, and a second port.