Patents by Inventor Subramanian Marappan

Subramanian Marappan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
    Patent number: 9034798
    Abstract: Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: May 19, 2015
    Assignee: CAPROTEC BIOANALYTICS GMBH
    Inventors: Hubert Köster, Daniel Paul Little, Suhaib Mahmood Siddiqi, Matthew Peter Grealish, Subramanian Marappan, Chester Frederick Hassman, III, Ping Yip
  • NUCLEOTIDE ANALOGS
    Publication number: 20120040340
    Abstract: The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids.
    Type: Application
    Filed: October 27, 2011
    Publication date: February 16, 2012
    Applicant: HELICOS BIOSCIENCES CORPORATION
    Inventors: J. William Efcavitch, Suhaib Siddiqi, Philip R. Buzby, Judith Mitchell, Edyta Krzymanska-Olejnik, Subramanian Marappan, Xiaopeng Bai, Atanu Roy, Mirna Jarosz, Jayson Bowers
  • Nucleotide analogs
    Patent number: 8114973
    Abstract: The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids.
    Type: Grant
    Filed: October 2, 2008
    Date of Patent: February 14, 2012
    Assignee: Helicos Biosciences Corporation
    Inventors: Suhaib Siddiqi, Subramanian Marappan, Judith Mitchell, Edyta Krzymanska-Olejnik, Atanu Roy, Xiaopeng Bai
  • Nucleotide analogs
    Patent number: 8071755
    Abstract: The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids.
    Type: Grant
    Filed: April 4, 2008
    Date of Patent: December 6, 2011
    Assignee: Helicos Biosciences Corporation
    Inventors: J. William Efcavitch, Suhaib Siddiqi, Philip R. Buzby, Judith Mitchell, Edyta Krzymanska-Olejnik, Subramanian Marappan, Xiaopeng Bai, Atanu Roy, Mirna Jarosz, Jayson Bowers
  • Methods and compositions for sequencing a nucleic acid
    Patent number: 7994304
    Abstract: The invention provides a family of tethered nucleotide analogs useful in sequencing nucleic acids containing a homopolymer region comprising, for example, two or more base repeats, and to sequencing methods using such tethered nucleotide analogs.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: August 9, 2011
    Assignee: Helicos Biosciences Corporation
    Inventors: Suhaib Siddiqi, Hernan Orgueira, Edyta Olejnik, Subramanian Marappan, Philip R. Buzby, Atanu Roy
  • NUCLEOTIDE ANALOGS
    Publication number: 20110081647
    Abstract: The invention generally relates to nucleotide analogs and methods of their use in sequencing-by-synthesis reactions. In certain embodiments, the invention provides a nucleotide analog including a detectable label attached to a nitrogenous base portion of a nucleotide analog by a cleavable linker, in which contact of the analog with at least one activating agent results in cleavage of the label and elimination of the linker, thereby producing a natural nucleotide, a 9-deaza-G, 9-deaza-A, or ?-uridine.
    Type: Application
    Filed: December 4, 2009
    Publication date: April 7, 2011
    Applicant: HELICOS BIOSCIENCES CORPORATION
    Inventors: Suhaib Siddiqi, J. William Efcavitch, Judith Mitchell, Subramanian Marappan, Jayson Bowers, Mirna Jaroza
  • Method of preparation of novel nucleoside analogs and uses
    Publication number: 20110070192
    Abstract: Processes for the preparation of racemic and optically active nucleoside analogs of formula (A) are described. These compounds are useful as anti-infective agents, antisense therapeutic agents and hybridization assay probes.
    Type: Application
    Filed: November 8, 2004
    Publication date: March 24, 2011
    Inventors: Bruno Tse, Borcherng Hong, Wei-Hung Chen, Yea-Fen Jiang, Shuo-Cang Zhang, Subramanian Marappan, Sepehr Sarshar
  • Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
    Publication number: 20100298168
    Abstract: Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.
    Type: Application
    Filed: April 7, 2010
    Publication date: November 25, 2010
    Inventors: Hubert Köster, Daniel Paul Little, Suhaib Mahmood Siddiqi, Matthew Peter Grealish, Subramanian Marappan, Chester Frederick Hassman, III
  • Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
    Publication number: 20100248264
    Abstract: Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.
    Type: Application
    Filed: February 26, 2010
    Publication date: September 30, 2010
    Inventors: Hubert Kõster, Daniel Paul Little, Suhaib Mahmood Siddiqi, Matthew Peter Grealish, Subramanian Marappan, Chester Frederick Hassman, III, Ping Yip
  • pH sensitive prodrugs of 2,6-diisopropylphenol
    Patent number: 7691904
    Abstract: The present invention is directed to water-soluble derivatives of 2,6-diisopropylphenol (Propofol). The compounds act as prodrugs of 2,6-diisopropylphenol and metabolize rapidly to Propofol thereby providing an alternative to the water-insoluble 2,6-diisopropylphenol. Pharmaceutical compositions comprising these compounds, methods of induction and maintenance of anesthesia or sedation as well as methods of treating neurodegenerative diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
    Type: Grant
    Filed: July 24, 2007
    Date of Patent: April 6, 2010
    Assignee: Auspex Pharmaceuticals, Inc
    Inventors: Subramanian Marappan, Cris Davenport, Sepehr Sarshar
  • NUCLEOTIDE ANALOGS
    Publication number: 20090186351
    Abstract: The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids.
    Type: Application
    Filed: October 2, 2008
    Publication date: July 23, 2009
    Applicant: HELICOS BIOSCIENCES CORPORATION
    Inventors: Suhaib Siddiqi, Subramanian Marappan, Judith Mitchell, Edyta Krzymanska-Olejnik, Atanu Roy, Xiaopeng Bai
  • Nucleotide Analogs
    Publication number: 20090061437
    Abstract: The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids.
    Type: Application
    Filed: April 4, 2008
    Publication date: March 5, 2009
    Applicant: HELICOS BIOSCIENCES CORPORATION
    Inventors: J. William Efcavitch, Suhaib Siddiqi, Philip R. Buzby, Judith Mitchell, Edyta Krzymanska-Olejnik, Subramanian Marappan, Xiaopeng Bai, Atanu Roy, Mirna Jarosz, Jayson Bowers
  • pH sensitive prodrugs of 2,6-diisopropylphenol
    Publication number: 20080248093
    Abstract: The present invention is directed to water-soluble derivatives of 2,6-diisopropylphenol (Propofol). The compounds act as prodrugs of 2,6-diisopropylphenol and metabolize rapidly to Propofol thereby providing an alternative to the water-insoluble 2,6-diisopropylphenol. Pharmaceutical compositions comprising these compounds, methods of induction and maintenance of anesthesia or sedation as well as methods of treating neurodegenerative diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
    Type: Application
    Filed: July 24, 2007
    Publication date: October 9, 2008
    Inventors: Subramanian Marappan, Cris Davenport, Sepehr Sarshar
  • Methods And Compositions For Sequencing A Nucleic Acid
    Publication number: 20080227970
    Abstract: The invention provides a family of tethered nucleotide analogs useful in sequencing nucleic acids containing a homopolymer region comprising, for example, two or more base repeats, and to sequencing methods using such tethered nucleotide analogs.
    Type: Application
    Filed: October 30, 2007
    Publication date: September 18, 2008
    Applicant: Helicos BioSciences Corporation
    Inventors: Suhaib Siddiqi, Hernan Orgueira, Edyta Kvzymanska-Olejnik, Subramanian Marappan, Philip R. Buzby, Atanu Roy
  • Methods and compositions for sequencing a nucleic acid
    Publication number: 20080103053
    Abstract: The invention provides a family of tethered nucleotide analogs useful in sequencing nucleic acids containing a homopolymer region comprising, for example, two or more base repeats, and to sequencing methods using such tethered nucleotide analogs.
    Type: Application
    Filed: May 14, 2007
    Publication date: May 1, 2008
    Applicant: Helicos BioSciences Corporation
    Inventors: Suhaib Siddiqi, Hernan Orgueira, Edyta Krzymanska-Olejnik, Subramanian Marappan, Philip R. Buzby, Atanu Roy
  • PH sensitive prodrugs of 2,6-Diisopropylphenol
    Patent number: 7250412
    Abstract: The present invention is directed to water-soluble derivatives of 2,6-diisopropylphenol (Propofol). The compounds act as prodrugs of 2,6-diisopropylphenol and metabolize rapidly to Propofol thereby providing an alternative to the water-insoluble 2,6-diisopropylphenol. Pharmaceutical compositions comprising these compounds, methods of induction and maintenance of anesthesia or sedation as well as methods of treating neurodegenerative diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
    Type: Grant
    Filed: March 15, 2004
    Date of Patent: July 31, 2007
    Assignee: Auspex Pharmaceuticals, Inc.
    Inventors: Subramanian Marappan, Cris Davenport, Sepehr Sarshar
  • Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
    Publication number: 20060051879
    Abstract: Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.
    Type: Application
    Filed: January 16, 2004
    Publication date: March 9, 2006
    Inventors: Hubert Koster, Daniel Little, Suhaib Siddiqi, Matthew Grealish, Subramanian Marappan, Chester Hassman, Ping Yip
  • Ph sensitive prodrugs of 2,6-diisopropylphenol
    Publication number: 20050234050
    Abstract: The present invention is directed to water-soluble derivatives of 2,6-diisopropylphenol (Propofol). The compounds act as prodrugs of 2,6-diisopropylphenol and metabolize rapidly to Propofol thereby providing an alternative to the water-insoluble 2,6-diisopropylphenol. Pharmaceutical compositions comprising these compounds, methods of induction and maintenance of anesthesia or sedation as well as methods of treating neurodegenerative diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
    Type: Application
    Filed: March 15, 2004
    Publication date: October 20, 2005
    Inventors: Subramanian Marappan, Cris Davenport, Sepehr Sarshar
  • Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
    Publication number: 20050042771
    Abstract: Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.
    Type: Application
    Filed: January 16, 2004
    Publication date: February 24, 2005
    Inventors: Hubert Koster, Daniel Little, Suhaib Siddiqi, Matthew Grealish, Subramanian Marappan, Chester Hassman, Ping Yip