Patents by Inventor Subramanian YEGNESWARAN

Subramanian YEGNESWARAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Epitope of optimized humanized monoclonal antibodies against activated protein C and uses thereof
    Patent number: 11077187
    Abstract: Provided are optimized humanized antibodies that selectively bind to and inhibit activated protein C without binding to or inhibiting unactivated protein C. In particular, the antibodies bind to particular epitopes outside the catalytic triad of the active site of human activated protein C. Methods of treatment employing these antibodies are described herein.
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: August 3, 2021
    Assignee: OKLAHOMA MEDICAL RESEARCH FOUNDATION
    Inventors: Xiao-Yan Zhao, Andreas Wilmen, Christoph Freiberg, Lars Linden, Ji-Yun Kim, Subramanian Yegneswaran, Karin Regnstrom, Ursula Egner, Xinquan Wang
  • EPITOPE OF OPTIMIZED HUMANIZED MONOCLONAL ANTIBODIES AGAINST ACTIVATED PROTEIN C AND USES THEREOF
    Publication number: 20180326053
    Abstract: Provided are optimized humanized antibodies that selectively bind to and inhibit activated protein C without binding to or inhibiting unactivated protein C. In particular, the antibodies bind to particular epitopes outside the catalytic triad of the active site of human activated protein C. Methods of treatment employing these antibodies are described herein.
    Type: Application
    Filed: November 15, 2016
    Publication date: November 15, 2018
    Inventors: Xiao-Yan ZHAO, Andreas WILMEN, Christoph FREIBERG, Lars LINDEN, Ji-Yun KIM, Subramanian YEGNESWARAN, Karin REGNSTROM, Ursula EGNER, Xinquan WANG