Abstract: The present disclosure relates to the field of oncology and particularly towards a combination therapy for treatment of cancer. In particular, the present disclosure provides a combination therapy comprising chloroquine, metformin and statin, for treatment/management of Myeloproliferative neoplasms (MPNs) or any associated condition. The combinations of the present disclosure show a synergistic cytotoxic activity against cancer cells. The present disclosure also relates to a composition comprising said combination, and a method for treatment/management of MPN or any associated condition by employing said composition or combination therapy. The present disclosure also provides combination of chloroquine, metformin and statin for use in treatment/management of MPN or any associated condition.

Abstract: A bi-directional buffer includes at least a first and second pair of one-shots and transistors. At least the first pair of one-shots and the first pair of transistors enable a second input/output (I/O) terminal to follow a first I/O terminal. At least the second pair of one-shots and the second pair of transistors enable the first I/O terminal to follow the second I/O terminal. There is a detection of whether the direction of a signal is from the first I/O terminal to second I/O terminal, or vise versa. If the direction is from the first I/O terminal to the second I/O terminal, there is an at least temporarily disabling the second pair of one-shots to thereby reduce feedback that may occur from the second I/O terminal to the first I/O terminal. If the direction is from the second I/O terminal to the first I/O terminal, there is an at least temporarily disabling the first pair of one-shots to thereby reduce feedback that may occur from the first I/O terminal to the second I/O terminal.

Abstract: A bi-directional buffer includes at least a first and second pair of one-shots and transistors. At least the first pair of one-shots and the first pair of transistors enable a second input/output (I/O) terminal to follow a first I/O terminal. At least the second pair of one-shots and the second pair of transistors enable the first I/O terminal to follow the second I/O terminal. There is a detection of whether the direction of a signal is from the first I/O terminal to second I/O terminal, or vise versa. If the direction is from the first I/O terminal to the second I/O terminal, there is an at least temporarily disabling the second pair of one-shots to thereby reduce feedback that may occur from the second I/O terminal to the first I/O terminal. If the direction is from the second I/O terminal to the first I/O terminal, there is an at least temporarily disabling the first pair of one-shots to thereby reduce feedback that may occur from the first I/O terminal to the second I/O terminal.

Abstract: A novel device for pole splitting which can be employed in multistage amplifiers having a final stage and a prior stage. The device comprises a first capacitor connected between the output of the prior stage and the output of the final stage, a source follower, and a second capacitor connected between the output of the prior stage and the source follower. The source follower provides an offset voltage that reduces variation of the total capacitance of the first and second capacitors. In a preferred version of the present invention, the first and second capacitor each comprise a MOSFET transistor having a certain threshold voltage. The offset voltage is set to be at least the threshold voltage of the MOSFET transistors. In a preferred version, the source follower comprises a plurality of MOSFET transistors, which includes a MOSFET transistor having a gate connected to the first capacitor and a source connected to the second capacitor.