Abstract: The present invention relates to cell specific therapeutic modality by using a region of the PLAP Promoter. The invention further relates to specific expression of therapeutically PLAP useful sequences for specific transcriptional activation of this gene. The invention also relates to the PLAP region which may be used alone or in combination with other regions like enhancer sequences that augment cell or tumour specific gene expression.

Abstract: This invention relates to a high affinity recombinant humanized antibody fragment (scFv) specific for hepatitis B surface antigen having unique inter/intra chain bonding interaction because of 28 altered amino acid residues from the original mouse (5S) antibody and its chimeric Fab form, wherein fine tuning of the vernier zone residue makes it closer to the human sequence without any structural constraints.

Abstract: The present invention demonstrates for the first time that FAT1 plays an important role in modulating PDCD4 expression, which in turn regulates AP-1 dependent transcription, controls processes crucial for migration and invasion in cancer cells, controls induction of a pro-inflammatory micro environment in cancer cells. The study illustrates a link between inflammation and cancer in cells or in a subject. This work highlights the importance of FAT1 in the induction of the cellular pathways of migration and invasion, proteolysis of the ECM and the expression of pro-inflammatory molecules leading to a favorable micro environment for tumor and cancer progression.

Abstract: The present invention relates to cell specific therapeutic modality by using a region of the PLAP Promoter. The invention further relates to specific expression of therapeutically PLAP useful sequences for specific transcriptional activation of this gene. The invention also relates to the PLAP region which may be used alone or in combination with other regions like enhancer sequences that augment cell or tumour specific gene expression.

Abstract: The present invention demonstrates for the first time that FAT1 plays an important role in modulating PDCD4 expression, which in turn regulates AP-1 dependent transcription, controls processes crucial for migration and invasion in cancer cells, controls induction of a pro-inflammatory micro environment in cancer cells. The study illustrates a link between inflammation and cancer in cells or in a subject. This work highlights the importance of FAT1 in the induction of the cellular pathways of migration and invasion, proteolysis of the ECM and the expression of pro-inflammatory molecules leading to a favorable micro environment for tumor and cancer progression.

Abstract: In order to produce a set of medical findings based on image data which has been obtained by way of different imaging methods, a plurality of image viewer programs has hitherto been required. In at least one embodiment, a viewer device is to be provided, with which different image data can be viewed and with which it is simultaneously possible to produce a set of medical findings. According to at least one embodiment of the invention, a method is provided wherein a base page and at least one content page with display elements are selected and are loaded and activated by a program.

Abstract: In at least one embodiment, if the pre-start level has the value empty container, the computer creates a container within the framework of the pre-start but does not load any application into the container. If the pre-start level has the value application, the computer creates a respective container within the framework of the pre-start for each application. If the pre-start level has a higher value, the computer determines within the framework of the pre-start a degree of grouping for the applications assigned to the respective pre-started unit, and groups the applications in accordance with the degree of grouping determined into at least one container group. Within the framework of the processing of the complex tasks, the computer terminates on switching from one application to another application, the application still being executed only if the application involves an application not able to be suspended.

Abstract: An effective and user-friendly system is disclosed for creating and running a software application for medical imaging, having at least one framework which has a service layer and a superordinate toolkit layer as an application programming interface, wherein functions of the toolkit layer and of the service layer are grouped in each case in a number of components which are arranged strictly hierarchically in such a way that any component can only ever be accessed from a superordinate component.

Abstract: A system and a computer-implemented method are disclosed, as well as a computer readable medium, for providing a number of web services for at least one medical viewing application, so as to provide the application with application-exceeding basic functionalities with regard to a transfer management service, a data management service, a workflow management service, a report management service, a protocol management service, an operating management service and an enterprise application integration management service. A web service of at least one embodiment, in that case, includes at least one remote service component, at least one business object and at least one service component.

Abstract: A method and an associated arrangement are disclosed for producing medical reports. The method is embodied in a medical data management system. in t least one embodiment, provision is made here for storing cross-reference data which cross-refers to object data that is obtained by way of various medical applications. The cross-reference data is used when producing medical reports, in order to include the associated object data, which is identified by the cross-reference data, in the report. in at least one embodiment, this results in an advantageous time saving when producing a medical report which can be considerable, particularly in the context of complex series of examinations involving various medical applications.

Abstract: In at least one embodiment, if the pre-start level has the value empty container, the computer creates a container within the framework of the pre-start but does not load any application into the container. If the pre-start level has the value application, the computer creates a respective container within the framework of the pre-start for each application. If the pre-start level has a higher value, the computer determines within the framework of the pre-start a degree of grouping for the applications assigned to the respective pre-started unit, and groups the applications in accordance with the degree of grouping determined into at least one container group. Within the framework of the processing of the complex tasks, the computer terminates on switching from one application to another application, the application still being executed only if the application involves an application not able to be suspended.

Abstract: A method and a medical computer system for executing the method are disclosed for reducing the waiting time for at least one user of the computer system when they first execute at least one work step in the computer system. The method includes pre-starting a process which is not yet assigned to a user, and loading the services into the process, which the applications initiated by a user to execute the at least one work step are very likely to call without the user already being assigned to the process.

Abstract: This invention relates to a high affinity recombinant humanized antibody fragment (scFv) specific for hepatitis B surface antigen having unique inter/intra chain bonding interaction because of 28 altered amino acid residues from the original mouse (5S) antibody and its chimeric Fab form, wherein fine tuning of the vernier zone residue makes it closer to the human sequence without any structural constraints.

Abstract: A system and a computer-implemented method are disclosed, as well as a computer readable medium, for providing a number of web services for at least one medical viewing application, so as to provide the application with application-exceeding basic functionalities with regard to a transfer management service, a data management service, a workflow management service, a report management service, a protocol management service, an operating management service and an enterprise application integration management service. A web service of at least one embodiment, in that case, includes at least one remote service component, at least one business object and at least one service component.

Abstract: In order to produce a set of medical findings based on image data which has been obtained by way of different imaging methods, a plurality of image viewer programs has hitherto been required. In at least one embodiment, a viewer device is to be provided, with which different image data can be viewed and with which it is simultaneously possible to produce a set of medical findings. According to at least one embodiment of the invention, a method is provided wherein a base page and at least one content page with display elements are selected and are loaded and activated by a program.

Abstract: The invention relates to a recombinant chimeric Fab antibody comprising a recombinant Fd and a recombinant chimeric light chain which binds to hepatitis B surface antigen with high affinity, generated by fusing variable region genes (VH and VL) of an anti-HBsAg mouse antibody 5S and constant region genes of human, CH1 region of human IgGI and the CL region of human kappa chain, wherein mouse VL and human CL are linked by overlap PCR to generate chimeric light chain and mouse VH and CH1 are linked by overlap PCR to generate chimeric Fd.

Abstract: An effective and user-friendly system is disclosed for creating and running a software application for medical imaging, having at least one framework which has a service layer and a superordinate toolkit layer as an application programming interface, wherein functions of the toolkit layer and of the service layer are grouped in each case in a number of components which are arranged strictly hierarchically in such a way that any component can only ever be accessed from a superordinate component.