Abstract: Systems and methods are disclosed for providing memory channel interleaving with selective power/performance optimization. One such method comprises configuring an interleaved zone for relatively higher performance tasks, a linear address zone for relatively lower power tasks, and a mixed interleaved-linear zone for tasks with intermediate performance requirements. A boundary is defined among the different zones using a sliding threshold address. The zones may be dynamically adjusted, and/or new zones dynamically created, by changing the sliding address in real-time based on system goals and application performance preferences. A request for high performance memory is allocated to a zone with lower power that minimally supports the required performance, or may be allocated to a low power memory zone with lower than required performance if the system parameters indicate a need for aggressive power conservation. Pages may be migrated between zones in order to free a memory device for powering down.