Patents by Inventor Sudan He

Sudan He has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heteroaryl compounds as inhibitors of programmed necrosis pathway, composition and method using the same
    Publication number: 20230121233
    Abstract: The present disclosure provides heteroaryl compounds of Formula I, processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from or related to the programmed necrosis pathway.
    Type: Application
    Filed: January 4, 2021
    Publication date: April 20, 2023
    Inventors: Xiaohu Zhang, Haikuo MA, Sudan HE
  • Heteroaryl compounds as inhibitors of necrosis, composition and method using the same
    Patent number: 11339177
    Abstract: The present disclosure provides heteroaryl compounds of Formula (I), processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from or related to necrosis.
    Type: Grant
    Filed: June 23, 2018
    Date of Patent: May 24, 2022
    Assignee: Accro Bioscience (HK) Limited
    Inventors: Xiaohu Zhang, Haikuo Ma, Jiyue Zheng, Sudan He
  • HETEROARYL COMPOUNDS AS NECROSIS INHIBITORS, COMPOSITION AND METHOD USING THE SAME
    Publication number: 20220112188
    Abstract: The present disclosure provides heteroaryl compounds of Formula (I), processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from or related to necrosis.
    Type: Application
    Filed: January 11, 2020
    Publication date: April 14, 2022
    Inventors: Xiaohu Zhang, Sudan He, Haikuo MA
  • HETEROARYL COMPOUNDS AS INHIBITORS OF NECROSIS, COMPOSITION AND METHOD USING THE SAME
    Publication number: 20210155635
    Abstract: The present disclosure provides heteroaryl compounds of Formula (I), processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from or related to necrosis.
    Type: Application
    Filed: June 23, 2018
    Publication date: May 27, 2021
    Inventors: Xiaohu Zhang, Haikuo Ma, Jiyue Zheng, Sudan He
  • Heteroaryl compounds as inhibitors of necrosis, composition and application thereof
    Patent number: 10815226
    Abstract: The present disclosure provides heteroaryl compounds of formulas I, Ia and Ib, processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from or related to necrosis.
    Type: Grant
    Filed: July 15, 2017
    Date of Patent: October 27, 2020
    Assignee: ACCRO BIOSCIENCE INC.
    Inventors: Xiaohu Zhang, Haikuo Ma, Jiyue Zheng, Sudan He
  • Necrosis inhibitors
    Patent number: 10682319
    Abstract: The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: June 16, 2020
    Assignee: National Institute of Biological Sciences, Beijing
    Inventors: Zhiyuan Zhang, Xiaodong Wang, Xiaoguang Lei, Yaning Su, Sudan He, Hanying Ruan, Liming Sun
  • HETEROARYL COMPOUNDS AS INHIBITORS OF NECROSIS, COMPOSITION AND APPLICATION THEREOF
    Publication number: 20190284180
    Abstract: The present disclosure provides heteroaryl compounds of formulas I, Ia and Ib, processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from or related to necrosis.
    Type: Application
    Filed: July 15, 2017
    Publication date: September 19, 2019
    Inventors: Xiaohu Zhang, Haikuo Ma, Jiyue Zheng, Sudan He
  • Necrosis Inhibitors
    Publication number: 20180263934
    Abstract: The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.
    Type: Application
    Filed: May 22, 2018
    Publication date: September 20, 2018
    Applicant: National Institute of Biological Sciences, Beijing
    Inventors: Zhiyuan Zhang, Xiaodong Wang, Xiaoguang Lei, Yaning Su, Sudan He, Hanying Ruan, Liming Sun
  • Necrosis inhibitors
    Patent number: 9974762
    Abstract: The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: May 22, 2018
    Assignee: National Institute of Biological Sciences, Beijing
    Inventors: Zhiyuan Zhang, Xiaodong Wang, Xiaoguang Lei, Yaning Su, Sudan He, Hanying Ruan, Liming Sun
  • Necrosis Inhibitors
    Publication number: 20170290790
    Abstract: The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.
    Type: Application
    Filed: June 26, 2017
    Publication date: October 12, 2017
    Applicant: National Institute of Biological Sciences, Beijing
    Inventors: Zhiyuan Zhang, Xiaodong Wang, Xiaoguang Lei, Yaning Su, Sudan He, Hanying Ruan, Liming Sun
  • Sesquiterpenoids
    Patent number: 9670226
    Abstract: The invention provides novel compounds and compositions for inhibiting IKK?/?, including treating disorders associated with IKK?/? activity, including cancer, autoimmune and inflammatory disorders, with a compound of structure:
    Type: Grant
    Filed: October 24, 2016
    Date of Patent: June 6, 2017
    Assignee: National Institute of Biological Sciences, Beijing
    Inventors: Xiaoguang Lei, Sudan He, Chao Li, Ting Dong
  • Sesquiterpenoids
    Publication number: 20170044180
    Abstract: The invention provides novel compounds and compositions for inhibiting IKK?/?, including treating disorders associated with IKK?/? activity, including cancer, autoimmune and inflammatory disorders, with a compound of structure:
    Type: Application
    Filed: October 24, 2016
    Publication date: February 16, 2017
    Applicant: National Institute of Biological Sciences, Beijing
    Inventors: Xiaoguang Lei, Sudan He, Chao Li, Ting Dong
  • Necrosis assay
    Patent number: 7622106
    Abstract: A necrosis assays is performed with a cell expressing RIPK1 and RIP3 by (a) culturing the cell with a smac mimetic, caspase-8 inhibitor and TNF-?; and (b) detecting a resultant necrosis of the cell.
    Type: Grant
    Filed: March 6, 2009
    Date of Patent: November 24, 2009
    Assignee: Board of Regents, The University of Texas System
    Inventors: Xiaodong Wang, Sudan He, Lai Wang